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Genome build information
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Phenotypic changes during cancer progression are associated with alterations in gene expression, which can be exploited to build molecular signatures for tumor stage identification and prognosis. However, it is not yet known whether the relative abundance of transcript isoforms may be informative for clinical stage and survival.
14p
vioraclene
31-03-2024
5
2
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Genomic locations are represented as coordinates on a specific genome build version, but the build information is frequently missing when coordinates are provided. We show that this information is essential to correctly interpret and analyse the genomic intervals contained in genomic track files. Although not a substitute for best practices, we also provide a tool to predict the genome build version of genomic track files.
5p
vialfrednobel
29-01-2022
9
0
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Traditional differential expression tools are limited to detecting changes in overall expression, and fail to uncover the rich information provided by single-cell level data sets. We present a Bayesian hierarchical model that builds upon BASiCS to study changes that lie beyond comparisons of means, incorporating built-in normalization and quantifying technical artifacts by borrowing information from spike-in genes.
14p
viaristotle
29-01-2022
14
0
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The developmental gradient in monocot leaves has been exploited to uncover leaf developmental gene expression programs and chloroplast biogenesis processes. However, the relationship between the two is barely understood, which limits the value of transcriptome data to understand the process of chloroplast development.
30p
viarchimedes
26-01-2022
7
0
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Genetic maps have been fundamental to building our understanding of disease genetics and evolutionary processes. The gametes of an individual contain all of the information required to perform a de novo chromosome-scale assembly of an individual’s genome, which historically has been performed with populations and pedigrees.
19p
viarchimedes
26-01-2022
9
0
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High-throughput technology allows for genome-wide measurements at different molecular levels for the same patient, e.g. single nucleotide polymorphisms (SNPs) and gene expression. Correspondingly, it might be beneficial to also integrate complementary information from different molecular levels when building multivariable risk prediction models for a clinical endpoint, such as treatment response or survival.
13p
vioklahoma2711
19-11-2020
12
2
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When an item is published to a Semantic Bank, tags assigned to it are carried along. As a conse- quence, the bank’s members pool together not only the information items they have collected but also their organization schemes applied on those items. The technique of pooling together keywords has recently gained popularity through services such as del.icio.us [6], Flickr [25], and CiteULike [4] as a means for a community to collab- oratively build over time a taxonomy for the data they share.
5p
machuavo
19-01-2013
41
3
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Universal access means that enough services and information are available, accessible and acceptable to meet the different needs of all individuals. This requires that people can safely reach services without travelling for a long time or distance, and that those with disabilities can easily access buildings. Services and treatments must be affordable, and based on principles of equity such that poor people do not bear a higher burden from the cost than more wealthy people.
7p
ut_hai_can
25-12-2012
46
3
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The data collected and analyzed helps to inform dental public health policy and programming. It also provides a baseline for noting any improvements that may occur as a result of new oral health promotion and disease prevention initiatives with the goal of achieving better outcomes. One of the reasons oral health was included as a component of the CHMS was to enable future evaluation of the association of oral health with major health concerns such as diabetes, respiratory and cardiovascular diseases.
14p
quynho77
10-11-2012
48
0
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