Genome-wide analysis

After years of concentrated research efforts, the exact cause of Crohn’s disease (CD) remains unknown. Its accurate diagnosis, however, helps in management and preventing the onset of disease. Genomewide association studies have identified 241 CD loci, but these carry small log odds ratios and are thus diagnostically uninformative.

15p vibransone 28-03-2024 2 1   Download

The Wright’s fixation index (Fst) and the principal component analysis (PCA) are widely used methods in animal genetics studies. In paper we compared the power of these methods, their complementing each other and which of them is the most powerful.

15p vihagrid 30-01-2023 6 3   Download

(BQ) Ebook Chemical and functional genomic approaches to stem cell biology and regenerative medicine: Part 1 presents the following content: Embryonic stem cells; adult stem cells; genomewide expression analysis technologies; genomic cdna and rnai functional profiling and its potential application to the study of mammalian stem cells; chemical technologies: probing biology with small molecules.

162p runordie7 30-08-2022 3 2   Download

DNA methylation is one of the most commonly studied epigenetic marks, due to its role in disease and development. Illumina methylation arrays have been extensively used to measure methylation across the human genome. Methylation array analysis has primarily focused on preprocessing, normalization, and identification of differentially methylated CpGs and regions.

26p viarchimedes 26-01-2022 8 0   Download

The development of sequencing technologies has promoted the survey of genomewide chromatin accessibility at single-cell resolution. However, comprehensive analysis of single-cell epigenomic profiles remains a challenge.

27p viarchimedes 26-01-2022 7 0   Download

There exist few, if any, practical guidelines for predictive and falsifiable multi-omic data integration that systematically integrate existing knowledge. Disease modules are popular concepts for interpreting genomewide studies in medicine but have so far not been systematically evaluated and may lead to corroborating multiomic modules.

13p vitzuyu2711 29-09-2021 11 1   Download

As a newly characterized type of noncoding RNA, circular RNA (circRNA) has been shown to have functions in diverse biological processes of animals. It has been reported that several noncoding RNAs may regulate animals’ response to heat stress which can be easily induced by hyperthermia in summer. However, the expression and functions of circRNAs in the pituitary of sows and whether they participate in heat stress adaption are still unclear.

13p viansan2711 30-07-2021 9 1   Download

Glyphosate has become the most widely used herbicide in the world. Therefore, the development of new varieties of glyphosate-tolerant crops is a research focus of seed companies and researchers.

15p vijeeni2711 24-07-2021 10 0   Download

RNA sequencing (RNA-seq) is a high throughput technology that profiles gene expression in a genomewide manner. RNA-seq has been mainly used for testing differential expression (DE) of transcripts between two conditions and has recently been used for testing differential alternative polyadenylation (APA).

9p viflorida2711 30-10-2020 14 0   Download

Although ultrahigh-throughput RNA-Sequencing has become the dominant technology for genomewide transcriptional profiling, the vast majority of RNA-Seq studies typically profile only tens of samples, and most analytical pipelines are optimized for these smaller studies.

10p viflorida2711 30-10-2020 11 1   Download

Yield of rapeseed is determined by three components: silique number, seed number per silique and thousand seed weight. Seed number per silique and thousand seed weight are influenced by silique length, seed density, silique breadth, silique thickness and silique volume.

15p vihashirama2711 21-05-2020 10 1   Download

The DNA adenine methylation status on specific 5¢-GANTC-3¢ sites and its change during the establishment of plant–microbe interactions was demonstrated in several species ofa-proteobacteria. Restriction landmark genome scanning (RLGS), which is a high-resolution two dimensional DNA electrophoresis method, was used to monitor the genomewide change in methylation.

12p galaxyss3 21-03-2013 44 2   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Uncovering the complexities of Kaposi’s sarcoma through genomewide expression analysis...

4p thulanh19 09-11-2011 44 1   Download