Genomics of laminitis

Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals express a mutant version of the nuclear envelope protein lamin A (termed progerin) and have previously been shown to exhibit prominent histone modification changes.

16p vibransone 28-03-2024 3 2   Download

Part2 book "Equine genomics" includes content: Genomics of skin disorders, genomics of muscle disorders, genomics of skeletal disorders, genomics of reproduction and fertility, genetics of equine neurologic disease, molecular genetic testing and karyotyping in the horse, genomics of laminitis, genomics of performance, genomics of the circadian clock, mitochondrial genome - Clues about the evolution of extant equids and genomic diversity of horse breeds.

178p oursky04 14-09-2023 4 2   Download

The nuclear envelope not only serves as a physical barrier separating nuclear content from the cytoplasm but also plays critical roles in modulating the three-dimensional organization of genomic DNA. For both plants and animals, the nuclear periphery is a functional compartment enriched with heterochromatin.

18p vigalileogalilei 27-02-2022 8 1   Download

Current three-dimensional (3D) genome modeling platforms are limited by their inability to account for radial placement of loci in the nucleus. We present Chrom3D, a user-friendly whole-genome 3D computational modeling framework that simulates positions of topologically-associated domains (TADs) relative to each other and to the nuclear periphery.

15p vialfrednobel 29-01-2022 3 1   Download

The dynamic 3D organization of the genome is central to gene regulation and development. The nuclear lamina influences genome organization through the tethering of lamina-associated domains (LADs) to the nuclear periphery.

27p viarchimedes 26-01-2022 6 0   Download

At the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-associated domains (LADs) aid functional organization of the genome. We review the organization of LADs and provide evidence of LAD heterogeneity from cell ensemble and single-cell data.

25p viarchimedes 26-01-2022 12 0   Download

Circular RNAs (circRNAs) are predominantly derived from protein coding genes, and some can act as microRNA sponges or transcriptional regulators. Changes in circRNA levels have been identified during human development which may be functionally important, but lineage-specific analyses are currently lacking. To address this, we performed RNAseq analysis of human embryonic stem (ES) cells differentiated for 90 days towards 3D laminated retina.

18p vibeauty 23-10-2021 18 2   Download

Large mega base-pair genomic regions show robust alterations in DNA methylation levels in multiple cancers. A vast majority of these regions are hypomethylated in cancers. These regions are generally enriched for CpG islands, Lamin Associated Domains and Large organized chromatin lysine modification domains, and are associated with stochastic variability in gene expression.

10p vinaypyidaw2711 26-08-2020 15 2   Download

The inner face of the nuclear envelope of metazoan cells is covered by a thin lamina consisting of a one-layered network of intermediate filaments inter-connecting with a complex set of transmembrane proteins and chromatin associating factors. The constituent proteins, the lamins, have recently gained tremendous recognition, because mutations in the lamin A gene,

8p galaxyss3 21-03-2013 32 3   Download