Growth failure
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The irreversible epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) afatinib and dac‑ omitinib are approved for first-line treatment of EGFR mutation-positive non-small cell lung cancer (NSCLC). We aimed to compare the efficacy and safety of afatinib and dacomitinib in this setting.
11p vikoch 27-06-2024 1 1 Download
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Global competition has intensified geographic repositioning of supply chain activities with implications for the economic prosperity of specific regions and geographies affected by such shifts. This study examines the relationship between the level of corruption and economic growth using the supply chain and ARDL bounds test method. The data used are GDP, the level of corruption, foreign direct investment, government spending and inflation from 2000-2018. The results of the study indicate a negative and significant impact on the level of corruption on economic growth in the long run.
11p longtimenosee09 08-04-2024 2 0 Download
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Nutritional interventions often fail to prevent growth failure in childhood and adolescent malnutrition and the mechanisms remain unclear. Recent studies revealed altered microbiota in malnourished children and anorexia nervosa.
12p vioraclene 31-03-2024 3 2 Download
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Dysregulation of inhibitor of differentiation/DNA binding (ID) genes is linked to cancer growth, angiogenesis, invasiveness, metastasis and patient survival. Nevertheless, few investigations have systematically determined the expression and prognostic value of ID genes in acute myeloid leukemia (AML).
12p vileonardodavinci 23-12-2023 2 2 Download
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As an adult tumor with the most invasion and the highest mortality rate, the inherent heterogeneity of glioblastoma (GBM) is the main factor that causes treatment failure. Therefore, it is important to have a deeper understanding of the pathology of GBM. Some studies have shown that Eukaryotic Initiation Factor 4A-3 (EIF4A3) can promote the growth of many people’s tumors, and the role of specific molecules in GBM remains unclear.
12p visharma 20-10-2023 2 2 Download
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Continued part 1, part 2 of ebook "Reliability design of mechanical systems: A guide for mechanical and civil engineers" provides readers with contents including: mechanical system failures; parametric accelerated life testing in mechanical/civil system; parametric ALT and its case studies; parametric ALT: a powerful tool for future engineering development;...
171p thamnhuocgiai 24-09-2023 7 2 Download
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To obtain a better understanding of the fatigue properties and crack growth characteristics of a nanocrystalline titanium based bulk metal glasses (Ti-BMG) made by vacuumed casting process, the fatigue failure mechanisms of Ti-BMG have been investigated via S e N and da/dN e DK tests.
7p viberbers 09-08-2023 8 3 Download
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Uterine implantation failure can be caused by uterine pathologies, including endometrial thinning or adhesions. This investigation aims to evaluate the effect of platelet-rich plasma (PRP) on endometrial regeneration.
8p viberbers 09-08-2023 8 3 Download
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The toxicity of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is less than that of cytotoxic agents. The reports of dramatic response and improvement in performance status with the use of EGFR TKIs may influence a physician’s decision-making for patients with non-squamous non-small cell lung cancer (NSCLC) and life-threatening respiratory distress.
8p viisaacnewton 26-04-2022 13 1 Download
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Extracorporeal membrane oxygenation (ECMO) is often used in critical patients with severe myocardial failure. However, the mortality rate of patients on ECMO is often high. Recent studies have suggested that endothelial activation with subsequent vascular barrier breakdown is a critical pathogenic mechanism of organ damage and is related to the outcome of critical illness.
8p vizhangzhidong 29-12-2021 7 0 Download
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Congenital scoliosis caused by failure of multiply vertebral segmentation with concave fused rib or unsegmented bar combined with contralateralhemivertebra is usually rigid and produces enormous asymmetric growth.
9p vimackenziebezos 30-11-2021 15 1 Download
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Local ablative therapy (LAT) may be benefcial for patients with epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer (NSCLC) with oligo-residual disease after treatment with EGFR tyrosine kinase inhibitor (EGFR-TKI). However, this has not been fully established. This study aimed to evaluate the predominant progressive disease (PD) pattern limited to residual sites of disease after treatment with EGFR-TKI.
10p vimahuateng 26-11-2021 13 0 Download
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These datasets are generated from Ford assembly line in a 6-month period focusing mostly on failure occurrence. The predictive power of the proposed model is supported in both data sets. Results suggest that Station, Model, Feature and Operation are four significant control parameters as they possess a more noticeable predictive power in comparison to time factor. To generalize the study area, other potential modelling methods are also implied for future research and other scenarios.
14p huyetthienthan 23-11-2021 16 2 Download
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The purpose of this paper is to identify factors that are affecting startup performance of small and medium enterprises (SMEs) in the Mekong Delta Region, in which this paper also analysis the important role of corporate social responsibility affecting firm’s startup performance. The study results indicate the suitability of the research model with data’s research as well as the acceptance of the hypothesis in corporate social responsibility (CSR).
15p huyetthienthan 23-11-2021 8 0 Download
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Maritime spatial planning (MSP) arose in the beginning of the millennium as a response to a historic failure to protect the marine environment, because of an increased competition for marine space and the opportunities for economic growth.
7p wangxinling 23-07-2021 26 1 Download
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Intensive selection for growth rate (GR) in broiler chickens carries negative after-effects, such as aberrations in skeletal development and the immune system, heart failure, and deterioration of meat quality.
12p vijeeni2711 24-07-2021 11 0 Download
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Chapter 4 - The mixed economy. Chapter objectives: The three questions of economics; profit motive, price mechanism, and capital; the circular flow model; market failure and externalities; the economic role of capital; the importance of specialization; the decline and fall of the communist system.
37p lovebychance04 20-05-2021 15 1 Download
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The purpose of this study was to compare the efficacy of osimertinib (OSI) versus afatinib (AFA) in patients with T790M-positive, non-small-cell lung cancer (NSCLC) and multiple central nervous system (CNS) metastases after failure of initial epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) treatment.
8p vijichoo2711 31-05-2021 11 1 Download
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Cell-free DNA (cfDNA) genotyping in plasma using the cobas EGFR Mutation Test v2 (cobas) is the first liquid biopsy as a companion diagnosis to identify the EGFR T790M mutation (T790M) after the failure of treatment of EGFR-tyrosine kinase inhibitors (TKIs) (1st generation, gefitinib [G] and erlotinib [E] and 2nd generation, afatinib [A]).
9p vianrose2711 27-04-2021 12 1 Download
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Patients with Acute Hypercapnic Respiratory Failure (AHRF) who are unresponsive to appropriate medical treatment, are often treated with Noninvasive Positive Pressure Ventilation (NPPV). Clinical predictors of the outcome of this treatment are scarce.
8p vimaine2711 26-03-2021 11 1 Download