H1299 cells
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PIKfyve is an evolutionarily conserved lipid and protein kinase enzyme that has pleiotropic cellular functions. The aim of the present study was to investigate the effects of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) inhibitor, YM201636, on nonsmall cell lung cancer (NSCLC) cells growth, tumorigenicity, and claudin (CLDN) expressions. Three NSCLC cell lines (Calu-1, H1299 and HCC827) were used to compare the effects of YM201636. Cytotoxic effects of YM201636 were analysed using XTT assay.
9p thiencuuchu 27-11-2021 10 1 Download
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Thirty to 40 % of non-small cell lung cancer (NSCLC) patients developed higher hypertriglyceridemia in the process of treatment with bexarotene. And bioinformatics studies discovered that the expression of slc10a2 was increased in high-grade hypertriglyceridemia patients.
10p vibaku2711 22-07-2020 6 1 Download
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Lin28B and its paralog Lin28A are small RNA binding proteins that have similar inhibitory effects, although they target separate steps in the maturation of let-7 miRNAs in mammalian cells.
8p vibaku2711 22-07-2020 10 1 Download
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The p53 tumor suppressor protein is mainly regulated by alterations in the half-life of the protein, resulting in significant differences in p53 protein levels in cells. The major regulator of this process is Mdm2, which ubiquitinates p53 and targets it for proteasomal degradation.
9p viuchiha2711 21-04-2020 12 0 Download
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This study determined the optimal nutrient and environmental conditions to produce antimicrobial and cytotoxic agents by Streptomyces cavourensis YBQ59 during the fermentation process. The bioactivities of eluted fractions based gradient solvents via chromatography column were also evaluated. S.
9p chauchaungayxua2 07-01-2020 50 1 Download
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Eugenol, eucalyptol, terpinen-4-ol, and camphor, used as flavor agents in cosmetic and food products, have both prooxidant and antioxidant activities. To clarify the mechanisms of their cytotoxic effect and the factors affecting their antioxidant prooxidant activities, we investigated cell membrane and DNA damage/protective effects induced by eugenol, eucalyptol, terpinen-4-ol, and camphor in parental and drug-resistant human lung cancer cell lines.
9p sony2711 01-02-2019 21 1 Download