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HepG2 cells
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In addition, their inhibitory activity on NO production and cytotoxic effects against human embryonic kidney cells (HEK-293A) and human hepatocellular carcinoma (HepG2) were evaluated. This is the first study of the phytochemical investigation of P. ginseng sprouts cultivated in Vietnam and ginseng sprouts also contained the same main active ginsenosides as in the 4–6-year old roots.
7p
dianmotminh02
03-05-2024
4
1
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The methanol extracts as well as some compounds from this plant exhibited anti-inflammatory, antimicrobial activity, antioxidant, hepatoprotective and anti-cancer effect, and antiosteoporotic. On going to search for bioactive components from the Vietnamese plant, this paper reported the isolation of seven phenolic compounds including one new from the aerial parts of A. ilicifolius. The cytotoxic activity of the isolates against two cancer cell lines (HepG2 and SK-LU1) were also screened and reported herein.
5p
dianmotminh02
03-05-2024
6
1
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The aim of this study was to investigate the interrelationships among PKC isoforms, telomerase and AFP in HCC. PKCα and PKCδ were the most expressed isoforms in HepG2/C3A, PLC/PRF/5, SNU-387 and SKOV-3 cells.
17p
vikissinger
21-12-2023
1
1
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Newcastle disease virus (NDV) is an oncolytic virus that can inhibit cancer cell proliferation and kill cancer cells. The NDV nonstructural V protein can regulate viral replication; however, whether the V protein contributes to NDV oncolysis is unclear.
10p
vischultz
20-10-2023
4
1
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As a continuation of our work on the bioactive constituents from Caesalpinia species, eight compounds (1−8) were isolated from the air-dried leaves of C. bonduc, collected from Vinh Phuc province of Vietnam. The cytotoxic activity of eight compounds (1–8) was screened on HepG2 human cancerous cells using the sulforhodamine B colorimetric assay.
8p
viberkshire
09-08-2023
5
4
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Macrosolen tricolor (Lec.) Dans. is a traditional medicinal plant and belongs to the family Loranthaceae, which is distributed in Nha Trang, and Phan Rang. This paper describes the isolation, structural elucidation, and cytotoxic activity of compounds from the ethyl acetate extract of the whole plant of M. tricolor (Lec.) Dans.
5p
vidoctorstrange
06-05-2023
4
2
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The study aimed to explore the molecular mechanisms of miR-124-3p which influence IR leading to T2DM establishment. HepG2 cells were cultured in vitro, and palmitic acid (PA) was used to construct the IR cell model. In the IR model, transfection of miR-124-3p or phosphoglucomutase 1 (PGM1) linked plasmids were transfected into HepG2 cells. RT-qPCR was used to determine the miR-124-3p and PGM1 expressions in the cells.
9p
lyhuyenthu
31-01-2023
3
2
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The acute toxicity, cytotoxicity, genotoxicity and antigenotoxic effects of BC were studied. Cytotoxicity of BC was evaluated in cultured C3A hepatoma cells (HepG2/C3A) using a lactate dehydrogenase (LDH) activity assay. Acute toxicity was tested in adults Wistar rats treated with a single dose of BC.
5p
vihermione
06-01-2023
13
3
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A major challenge in the treatment of liver cancer is that a large proportion of patients fail to achieve long-term disease control, with death from liver cancer cell migration and invasion. Acid-sensitive ion channel 1α (ASIC1α) is involved in the migration, invasion, and proliferation of liver cancer cells.
15p
viangelamerkel
27-07-2022
6
2
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The newly synthesized compounds were characterized and confirmed by analytical and spectroscopic data (IR, MS, 1H NMR, and 13C NMR). Pyrazolo[1,5-a]pyrimidines 5a–c and 9a–c and Schiff bases 11b–f were investigated for their cytotoxicity against four human cancer cell lines (colon HCT116, lung A549, breast MCF-7, and liver HepG2) according to SRB assay and the structure–activity relationship was discussed.
12p
langthannam
29-12-2021
14
0
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Aurora A kinase is a cell cycle regulator that is dysregulated in several different malignancies. Nevertheless, its regulatory mechanisms are still not fully understood. Here, we report that ubiquitin specific peptidase 3 (USP3) promotes proliferation and metastasis of esophageal squamous cell carcinoma (ESCC) cells by mediating deubiquitination of Aurora A.
13p
vimahuateng
26-11-2021
12
0
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This study was conducted to investigate the physicochemical, phytochemical, in vitro antidiabetic and anticancer potential of Olea ferruginea R bark. After extraction using Soxhlet, in vitro antidiabetic and cytotoxic activity on human hepatocellular carcinoma (HepG2) cells was assessed by nonenzymatic glycosylation of hemoglobin assay, alpha-amylase inhibition assay, glucose uptake by yeast cells, and 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay, respectively, and gene expression via real-time polymerase chain reaction.
12p
tudichquannguyet
29-11-2021
12
0
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Marine endophytic fungi (MEF) are good sources of structurally unique and biologically active secondary metabolites. Due to the increase in antimicrobial resistance, the secondary metabolites from MEF ought to be fully explored to identify candidates which could serve as lead compounds for novel drug development.
17p
vijeeni2711
24-07-2021
7
0
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Chemical investigation of the lichen Parmotrema praesorediosum (Nyl.) Hale led to isolate six phenolic compounds including praesorediosic (1), orcinol (2), orselinic acid (3), lecanorin (4), isolecanoric acid (5) and virensic acid (6). Among them, compound 1 appeared to be found for the first time in the nature. The structure of these compounds was elucidated by spectroscopic analyses of HRESIMS and NMR as well as the comparison of their NMR data with those in the literature.
5p
nguaconbaynhay11
16-04-2021
20
1
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Their structures were established by means of physical data (ESI MS, 1D and 2D NMR) and evaluated for the cytotoxic activities against liver hepatocellular carcinoma (HepG2), human lung cancer (NCI-H460), human epithelial carcinoma (HeLa) and human breast cancer (MCF-7) cell lines. This is the first report on phytochemical studies of this plant.
5p
nguaconbaynhay11
16-04-2021
20
2
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In this study, we conducted cytotoxicity assay of 7 ent-kaurane diterpenoids from Croton tonkinensis against HepG2 cancer cell line. Homology modeling was used to determine the 3D structure of mortalin and p53 crystal structure involved mortalin-binding site was selected. All studied compounds were submitted for molecular docking to investigate inhibition mechanism of bioactive compounds.
9p
nguaconbaynhay11
01-04-2021
10
2
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Xao Tam Phan (Paramignya trimera) has long been used in Viet Nam as an herbal medicine for the treatment of Hepatitis, hepatocellular carcinoma, and diabetes. This study aimed to determine the anti-proliferation effect of Paramignyatrimera extract(P.trimera extract) on HepG2 hepatocellular carcinoma cells.
6p
larachdumlanat127
02-01-2021
15
1
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Recently reported data have suggested that only a small subset of cancer cells possess the capability to initiate malignancies. These observations were based on investigation of cells within the primary tumors displaying a distinct surface marker pattern. CD133 marker is a putative hematopoietic and neuronal stem cell marker, which is also considered to be a tumorigenic marker in brain, prostate and liver. Recent studies have shown that a small population of CD133-positive cells, indeed, exists in human hepatocellular carcinoma (HCC) cell lines and primary HCC tissues.
11p
trinhthamhodang9
10-12-2020
24
1
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5-Chloro-2-hydroxybenzohydrazide and 2-hydroxy-5-iodobenzohydrazide were synthesized from 5-chloro-2-hydroxybenzoic acid and methyl 2-hydroxybenzoate (methyl salicylate), respectively. The reaction of these 5-halogeno-2-hydroxybenzohydrazides with appropriate heteryl methyl ketones gave eight new N-substituted hydrazides.
8p
tamynhan9
02-12-2020
5
2
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MicroRNA 21 (miR-21) has been demonstrated to be significantly elevated in many types of cancers, including the hepatocellular carcinoma (HCC). In the present study, we investigated the role of miR-21 in HCC by identifying its novel targets, as well as its underlying molecular mechanism.
9p
vijennie2711
29-09-2020
13
2
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