Identify mechanisms
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5-Fluorouracil (5FU) is a primary chemotherapeutic agent used to treat oral squamous cell carcinoma (OSCC). However, the development of drug resistance has significantly limited its clinical application. Therefore, there is an urgent need to determine the mechanisms underlying drug resistance and identify effective targets.
16p vishanshan 27-06-2024 2 1 Download
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Modulation of DNA damage repair in lung squamous cell carcinoma (LUSC) can result in the generation of neoantigens and heightened immunogenicity. Therefore, understanding DNA damage repair mechanisms holds significant clinical relevance for identifying targets for immunotherapy and devising therapeutic strategies.
15p vishanshan 27-06-2024 1 1 Download
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The aim of this qualitative study is to explore the perceptions of vision care after neurological impairment, and to identify possible inequalities and support mechanisms, where it has been possible to access vision care.
13p vishanshan 27-06-2024 2 1 Download
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This study is based on network pharmacology and molecular docking technology to predict the possible target of PSP treatment of breast cancer, and use experiments to verify the effect and mechanism of PSP on breast cancer.
14p vikoch 27-06-2024 1 1 Download
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A growing number of expression quantitative trait loci (eQTLs) have been found to be linked with tumorigenesis. In this article, we employed integrated Mendelian randomization (MR) analyses to identify novel susceptibility genes in renal cancer (RC) and reveal their potential mechanisms.
10p vikoch 27-06-2024 1 1 Download
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The role of novel circular RNAs (circRNAs) in colorectal cancer (CRC) remains to be determined. This study aimed to identify a novel circRNA involved in CRC pathogenesis, assess its diagnostic value, and construct a regulatory network.
10p vikoch 27-06-2024 1 1 Download
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The sialic acid binding Ig like lectin 15 (Siglec-15) was previously identified as tumor immune suppressor gene in some human cancers with elusive molecular mechanism to be elucidated. The continuous focus on both clinical and basic biology of bladder cancer leads us to characterize aberrant abundance of BACH1-IT2 associating with stabilization of Siglec-15, which eventually contributes to local immune suppressive microenvironment and therefore tumor advance.
11p vikoch 27-06-2024 2 1 Download
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This study aims to identify functionally relevant lncRNAs impacting OS proliferation and lipid metabolism and seeks to shed light on the upstream regulatory mechanisms governing lipogenic enzyme activity. Based on comprehensive bioinformatic analysis and the establishment of a risk model, we identified seven lncRNAs signifcantly associated with clinical characteristics and lipid metabolism-related genes in patients with OS.
15p vikoch 27-06-2024 1 1 Download
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Ovarian cancer is one of the most common gynecological malignancies due to the lack of early symptoms, early diagnosis and limited screening. Therefore, it is necessary to understand the molecular mechanism underlying the occurrence and progression of ovarian cancer and to identify a basic biomarker for the early diagnosis and clinical treatment of ovarian cancer.
13p vikoch 27-06-2024 1 1 Download
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Surface-enhanced Raman spectroscopy (SERS) is a powerful technique for identifying molecular species, but it has been primarily limited to noble metal supports. This study clarified the SERS mechanism based on semiconductor material - ZnO microtube in probing methylene blue (MB) as an equal contribution of charge transfer and SPR mechanisms.
10p viambani 18-06-2024 1 1 Download
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This paper deals with implementing Proper Generalized Decomposition (PGD) technique in solving the problem of identifying Young's modulus of linear elastic isotropic material from fullfield measurements by finite element model updating (FEMU) method.
10p viambani 18-06-2024 6 1 Download
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In this work, along with economic factors, considerable attention is paid to the assessment of human potential and the social component of the workforce. Unlike political, economic and investment factors, these elements are subject to changes in the short-run, and are engines of regional development and the most promising of its components. The purpose of the study is to develop a mechanism for assessing the level of regional development and identifying factors affecting this process.
10p longtimenosee10 26-04-2024 2 1 Download
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Ebook "Nuclear reprogramming and stem cells" provides a timely glimpse into the methods that have been developed to instigate, and the mechanisms that have been identified to drive, the process of nuclear reprogramming, chronicling how the field has developed over the last 50-60 years. Nuclear Reprogramming and Stem Cells will serve as a valuable resource for all researchers in the field of stem cell biology, including those just setting out on their career path as well as those already established in the field.
340p ladongphongthanh1008 22-04-2024 3 2 Download
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Ebook "Cancer biology and the nuclear envelope: Recent advances may elucidate past paradoxes" presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers and suggesting new avenues for the treatment of cancer.
610p tracanhphuonghoa1007 22-04-2024 3 1 Download
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With the increase of importance for collaboration, intelligence, operational integration with partners in supply chain and inter-organizational partnership, there has been change in the role of supply managers in improving corporate performance. This is reflected in the research related to firms and entrepreneurial settings. The mechanism identified in previous research studies along with the entrepreneurial skills and role of supply management have been explored in this research study.
8p longtimenosee09 08-04-2024 1 0 Download
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The paper discusses the concept and problem of identifying DDoS attacks for information management. The main starting mechanisms and types of DDoS attacks are analyzed. To identify them, signature and behavioral methods of analyzing network traffic are used. Analysis of the advantages and disadvantages of these methods actualized the need for their combined use. To detect and classify DDoS attacks, the need to develop and use a neural network model has been updated. The training and testing of the model were made on the initial data from the NSL-KDD set.
5p longtimenosee09 08-04-2024 4 1 Download
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The research paper delves into the intricate realm of IoT device security, unravelling the multifaceted risks and presenting a nuanced exploration of mitigation strategies. A comprehensive literature review unveils common security threads and the current state of IoT security measures. The subsequent analysis identifies security risks, including unauthorized access, encryption lapses, authentication weaknesses, physical vulnerabilities, and privacy concerns.
6p visergey 02-04-2024 7 0 Download
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Genome–phenome studies have identified thousands of variants that are statistically associated with disease or traits; however, their functional roles are largely unclear. A comprehensive investigation of regulatory mechanisms and the gene regulatory networks between phenome-wide association study (PheWAS) and genomewide association study (GWAS) is needed to identify novel regulatory variants contributing to risk for human diseases.
15p vibransone 28-03-2024 3 2 Download
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The etiology of ASD involves both inherited and environmental risk factors, with epigenetic processes hypothesized as one mechanism by which both genetic and non-genetic variation influence gene regulation and pathogenesis. The aim of this study was to identify DNA methylation biomarkers of ASD detectable at birth.
13p vibransone 28-03-2024 3 2 Download
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Recent studies have used genome-wide data to investigate evolutionary mechanisms related to behavioral phenotypes, identifying widespread signals of positive selection. Here, we conducted a genome-wide investigation to study whether the molecular mechanisms involved in these traits were affected by local adaptation.
12p vibransone 28-03-2024 2 2 Download