Immunotherapy tolerance
-
T-cells play a crucial role in the adaptive immune system by triggering responses against cancer cells and pathogens, while maintaining tolerance against self-antigens, which has sparked interest in the development of various T-cell-focused immunotherapies.
24p vicwell 29-02-2024 3 1 Download
-
Nutritional support, including nutritional counseling and oral nutritional supplements (ONS), has been recommended as a first-line strategy in patients with non-small cell lung cancer (NSCLC). Evidence on the efficacy of immunonutrition during immunotherapy in these patients is positive, but still limited some secondary endpoints, such as treatment toxicity and tolerance.
10p vileonardodavinci 23-12-2023 4 2 Download
-
Over the past decade, there has been increasing availability of novel therapeutics with improved tolerability and efficacy for advanced non-small cell lung cancer (NSCLC). The study goals were: to compare the uptake of systemic therapy (ST) before and after the availability of targeted tyrosine kinase inhibitors (TKI) and immunotherapy and to examine the changes in overall survival (OS) over time between younger and older adults with advanced NSCLC.
11p vischultz 20-10-2023 2 1 Download
-
Part 2 book "How the immune system works" includes content: Restraining the immune system, self tolerance and mhc restriction, immunological memory, the intestinal immune system, the immune system gone wrong, immunodeficiency, vaccines, cancer and the immune system, immunotherapy.
75p oursky05 20-09-2023 3 2 Download
-
Necroptosis plays an important role in hepatocellular carcinoma (HCC) development, recurrence, and immunotherapy tolerance. We aimed to build a new prognostic necroptosis-related gene signature that could be used for survival and immunotherapy prediction in HCC patients.
15p vioracle 29-09-2023 6 2 Download
-
Immunotherapy seems to be justified in PS 2 patients with NSCLC. This method of treatment has been proven to be safe and tolerable. However, outcomes in this population remain suboptimal and the impact of immunotherapy in this cohort is less dramatic.
7p lazzaro 30-12-2021 18 0 Download
-
Immune checkpoint blockades (ICBs) are characterized by a durable clinical response and better tolerability in patients with a variety of advanced solid tumors. However, we not infrequently encounter patients with hyperprogressive disease (HPD) exhibiting paradoxically accelerated tumor growth with poor clinical outcomes.
11p vianrose2711 27-04-2021 7 1 Download
-
Classical phase 1 dose-finding designs based on a single toxicity endpoint to assess the maximum tolerated dose were initially developed in the context of cytotoxic drugs. With the emergence of molecular targeted agents and immunotherapies, the concept of optimal biological dose (OBD) was subsequently introduced to account for efficacy in addition to toxicity.
10p vianrose2711 27-04-2021 13 1 Download
-
The future of combined immunotherapy (a PD-1/PD-L1 plus a CTLA-4 antagonist) is very bright. However, besides improving efficacy, combined therapy increases treatment-related adverse events (TRAEs). Also, the clinical application is limited in some solid tumors.
10p vikuala271 13-06-2020 10 1 Download
-
B-cell NHL is strongly associated with HCV that was proved in the last 2 decades. The most common HCV infection related B-NHL subtypes include MZL and DLBCL lymphomas. HCV-positive NHL patients usually present with older age at diagnosis, higher LDH, and more extranodal disease. The standard chemo-immunotherapy tolerance is generally good. Antiviral treatment achieves virological and hematological remission in HCV associated indolent lymphoma. More aggressive lymphoma requires combination of antiviral treatment and chemotherapy.
7p kequaidan1 16-11-2019 9 0 Download
-
Dendritic cells (DCs) are the most potent antigen-presenting cells (APCs) that affect prime naive T cells and create proper immune responses. The uncontrolled growth of cancer cells often results from the cell’s successful inhibition of cytotoxic T lymphocytes. In addition to conventional cancer treatments, including surgery, chemotherapy, and radiation therapy, immunotherapies have been seen to offer promising and innovative cancer treatments. Currently, DC therapy is one of the most popular immunotherapies because it uses tumour antigen-pulsed DC vaccines to fight against cancers.
5p caygaocaolon1 13-11-2019 10 0 Download
-
Subsistence agriculture to produce cassava, plantains, cocoyams, yams, maize, ground- nuts, etc, mainly for home consumption, is the main activity on the plain. Small quantities of cocoa (for sale) and coffee (mainly for home consumption) are produced. There are smallholder cooperative associations at lloani and Mbongo villages which pro- duce palm oil , from two small Stork mills of 5t FFB per day capacity. The oi l is sold on the local market through the Catholic Mission at Mbonge. Members earn about 110 000 CFAF a year from palm oil .
0p thieubaotrang 23-04-2013 50 3 Download
-
Climate change is likely to aid the spread of invasive alien species, further threatening agricultural productivity and food security through spread of weeds, pests, and diseases of crops and livestock. The introduction of new and adaptable exotic species for agriculture and to meet increasing demands for biofuels, mariculture, aquaculture, and reforestation presents a particular challenge.
74p yeurauxanh88 01-10-2012 38 3 Download