In situ repair
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Large-scale genomic alterations, especially CD274/PD-L1 gene amplification, have great impact on anti-PD-1 efficacy on cancers such as Hodgkin’s lymphoma. However, the prevalence of PD-L1 genetic alterations in colorectal cancer (CRC) and its correlation with the tumor immune microenvironment and clinical implications remain unknown.
11p vischultz 20-10-2023 1 1 Download
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The partial articular supraspinatus tendon avulsion (PASTA) lesion repair remains a topic of debate. We have performed in situ repair of PASTA lesions using a potentially viable threading lasso fxation technique. This ret‑ rospective case series aimed to evaluate the clinical outcomes of PASTA lesion repair using threading lasso fixation. To the best of our knowledge, this is the first study to review this technique and its outcomes in terms of pain and upper extremity function.
6p vimackenziebezos 30-11-2021 12 0 Download
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Multiple-ligament injured knee (MLIK) is a rare but severe injury. Although the principles of MLIK management have progressed over the past 40 years, there is a paucity of high-quality evidence upon which to base the management of MLIK.
8p vioregon2711 22-02-2021 10 2 Download
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h repeat-containing G-protein-coupled receptor 5 (LGR5) is a promising intestinal stem cell and carcinoma stem cell marker. We examined the relationship between mismatch repair (MMR) protein deficiency and LGR5 expression in poorly differentiated (PD) colorectal carcinoma (CRC).
6p viorochimaru2711 01-06-2020 9 1 Download
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In this report, thin layers of MoS2 were in-situ incorporated into graphene oxide (GO) to form MoS2/graphene nanocomposite by a facile ultrasonic-assisted hydrothermal method. Xray Diffraction (XRD) and Raman analysis revealed that the as-synthesized MoS2 nanosheets crystalized in hexagonal phase 2H-MoS2 while High Resolution Transmission Electron Microscopy (HRTEM) images confirmed that MoS2 layers with average thickness of ~5–6 nm (6–8 layers) attached on the edges and surfaces of graphene sheets with high density and uniform shape restacking in three-dimensional (3D) architectures.
11p chauchaungayxua2 07-01-2020 28 0 Download
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A new class of injectable, biocompatible and biodegradable hydrogel is reported. This hydrogel is derived from N-succinyl chitosan (SCS) mixed with water-soluble dialdehyde starch (DAS) without using a conventional chemical crosslinker. The hybrid hydrogel is formed owing to the Schiff’s base reaction between amine groups of SCS and dialdehyde groups of DAS to form ACH‚NA group. SCS, DAS, and SCS–DAS hybrid hydrogels were synthesized and then characterized by FTIR analysis spectroscopy.
9p kequaidan1 16-11-2019 13 1 Download