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In vivo toxicity limits
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Doxorubicin (Dox) is widely used to treat progressed bladder cancer after transurethral resection. The use of Dox-chemotherapy has been limited due to induced drug resistance and cumulative cardiotoxic effects. N-benzyladriamycin-14-valerate (AD198), a novel derivative of Dox, has a potential to become a more effective treatment than Dox by overcoming drug resistance and cardio-toxicity as shown in the rodent model of lymphoma in vivo.
11p
vimoscow2711
29-08-2020
13
1
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Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats
Most toxicity studies for POM93 have been performed in cultured cell lines rather than in animals. Like other POMs, there is a lack of evidence for in vivo toxicity limits, oral bioavailability, and therapeutic applications.
9p
vimax2711
30-03-2020
14
2
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The incidence of fungal infections is considered a serious public health problem worldwide. The limited number of antimycotic drugs available to treat human and animal mycosis, the undesirable side effects and toxicities of the currently available drugs, and the emergence of fungal resistance emphasizes the urgent need for more effective antimycotic medicines. In this paper, we describe a rapid, simple, and efficient synthetic route for preparation of the antifungal agent butenafine on a multigram scale.
11p
trinhthamhodang1
14-11-2019
13
0
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The current study was purposed to evaluate an acute toxicity and effects of lotus (Nulumbo nucifera Gaertn.) flower ethanolic extract (LFEE) on alloxan induced diabetic rats. In vivo acute toxicity study of LFEE was carried out via the guideline of the testing of Chemicals (OECD) by oral administration at limit test of 2000 mg/Kg and 5000 mg/Kg, the results showed that, LD50 was greater than the limit dose at 5000 mg/Kg.
7p
vithomasedison2711
14-08-2019
25
0
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