Induced aging

Xem 1-20 trên 31 kết quả Induced aging
  • Oxidative damage to mtDNA is associated with excessive reactive oxygen species production. The mitochondrial common deletion (mtDNA 4977-bp and 4834-bp deletion in humans and rats, respectively) is the most typical and frequent form of mtDNA damage associated with aging and degenera-tive diseases.

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  • The process of ageing has resulted in the emergence of a new epidemiological scenario in the developing countries with high prevalence of degenerative diseases that act as a major cause of death and disability and lack of mobility (Smith and Bares, 1991, Zwi, 1999). There are evidences of unhealthy ageing from almost all the developing countries of Asia, Africa, and Latin America. Pelaez and and Palloni (1998) have concluded that there is a long-run health degeneration in the ageing societies of the Caribbean and Latin America with changing disease pattern.

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  • Living arrangements, particularly overcrowded conditions and a lack of privacy, have been associated with conflict within families. Although abuse can occur when the abuser and the older person suffering abuse live apart, the older person is more at risk when living with the caregiver. The early theories on the subject also sought to associate dependency with increased risk of abuse.

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Hepatoprotection and neuroprotection induced by low doses of IGF-II in aging rats

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  • Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Hepatoprotection and neuroprotection induced by low doses of IGF-II in aging rats

    pdf9p dauphong8 14-01-2012 16 4   Download

  • To improve the diagnosis of tuberculosis (TB), more rapid diagnostic techniques such as antibody detection based on immunochromatographic methods were developed. The objective of this study was to evaluate the performance of the SD Rapid TB kit for the diagnosis of active TB with serums from patients and close contact controls in Antananarivo, Madagascar. Findings: We conducted a population-based case-control study. The sera of 60 confirmed TB patients and 60 healthy contacts paired for sex and age were tested.

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  • The molecular self-assembly is induced by variation in the surroundings, such as temperature [1-4], pressure [5-9], pH [10-14], salt formation [13-18], and noncovalent bond cross-linking [19- 21]. The block copolymers are molecularly converted in situ from the nonamphiphilic copolymers completely dissolved in a solvent to amphiphilic copolymers due to these stimuli. Therefore, the association and dissociation of the isolated copolymers are reversibly controlled by such stimuli.

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  • Because of the topographic setting of the city, the moderately strong insolation associated with its tropical latitude and high elevation, and weak prevailing synoptic winds, Mexico City is strongly affected by thermally and topographically induced circulation patterns.

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  • Ascorbic acid is often regarded as an antioxidantin vivo, where it protects against cancer by scavenging DNA-dam-aging reactive oxygen species. However, the detailed mech-anism of the action of ascorbic acid on genetic DNA is still unclear. We examined the effect of ascorbic acid on the higher-order structure of DNA through real-time observa-tion by fluorescence microscopy. We found that ascorbic acid generates a pearling structure in single giant DNA molecules, with elongated and compact regions coexisting along a molecular chain. ...

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Identification of collagen-induced arthritis loci in aged multiparous female mice...

    pdf6p thulanh12 13-10-2011 24 2   Download

  • Huntington’s disease (HD) is an inherited neurodegenerative disorder characterized by cortico-striatal dysfunction and loss of glutamate uptake. At 7 weeks of age, R6/2 mice, which model an aggressive form of juvenile HD, show a glutamate-uptake deficit in striatum that can be reversed by treatment with ceftriaxone, a b-lactam antibiotic that increases GLT1 expression. Only at advanced ages ( 11 weeks), however, do R6/2 mice show an actual loss of striatal GLT1. Here, we tested whether ceftriaxone can reverse the decline in GLT1 expression that occurs in older R6/2s.

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  • The effectiveness of screening in the NHSBSP is influenced by pro- gramme factors, such as the introduction of two views and the opti- misation of optical density, and also by population factors, such as the increasing use of hormone replacement therapy during the 1990s. The current NHSBSP saves an estimated 1400 lives each year in Eng- land. The NHSBSP now diagnoses about half of all breast cancers found in women in the target age range of 50–70 years, with the remainder occurring in women who do not attend for screening or who present symptomatically in the interval between screens.

    pdf81p taisaokhongthedung 07-01-2013 26 2   Download

  • Mitochondria regulate platelet metamorphosis induced by opsonized zymosan A – activation and long-term commitment to cell death Paola Matarrese1, Elisabetta Straface1, Giuseppe Palumbo2, Maurizio Anselmi2, Lucrezia Gambardella1, Barbara Ascione1, Domenico Del Principe2 and Walter Malorni1 1 Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita’, Rome, Italy 2 Department of Pediatrics, University of Rome Tor Vergata, Italy Keywords aggregation; apoptosis; mitochondrial membrane potential; platelets; zymosan Correspondence P.

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Search for age-dependent as compared to mutagen-induced mutations on the X-chromosome affecting viability in

    pdf7p toshiba21 16-11-2011 13 1   Download

  • Immunization Immunizations are one of the most important tools we have to protect children from a wide range of diseases, including polio, measles, mumps, rubella, influenza, tetanus, diph- theria, and pertussis. Without immunizations, a much larger number of children in North America would die each year or live with the chronic effects of these diseases. Immunization coverage can also be an indicator of access to primary health care.

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  • Probably, the closest related paper in the literature to this study is Glewwe (1999). Using cross-sectional data from Morocco, he estimates the impact that mothers’ health knowledge has on children’s long-term health status proxied by height for age Z-scores. The empirical approach taken by the author is careful in two distinct aspects. First, the database provides information that can help the researcher distinguish between general numeracy and literacy skills of the mother and their specific knowledge on health issues.

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  • he tumor suppressor, breast cancer susceptibility gene 1 (BRCA1), plays an integral role in the maintenance of genome stability and, in particular, the cellular response to DNA damage. Here, the emerging role of BRCA1 in nonhomologous end-joining-mediated DNA repair following DNA dam-age will be reviewed, as well as the activation of apoptotic pathways.

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  • The use of contraception increases with increasing education. Sixty percent of women with at least some secondary education use a contraceptive method, in contrast to 43 percent of women with no education. In general, women do not begin to use contraception until they have had at least one child. Fifty-two percent of women currently in union with three or four children are currently using a modern method of contraception. The use of modern methods among women currently in union peaks between age 25-39 (50-52 percent).

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  • Women's risk for many diseases increases at menopause, which occurs at a median age of 51.4 years. In the industrialized world, women spend one-third of their lives in the postmenopausal period. Estrogen levels fall abruptly at menopause, inducing a variety of physiologic and metabolic responses. Rates of cardiovascular disease increase and bone density begins to decrease rapidly after menopause. In the United States, women live on average about 5 years longer than men, with a life expectancy at birth in 2004 of 80.4 years, compared to 75.2 years in men.

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  • We also examine the determinants of the return gap. We find that estimated trading costs are negatively related to the return gap. Also, most funds in our sample exhibit relatively large correlations between the hypothetical holdings returns and the investor returns, indicating that their actual investment strategies do not differ significantly from their disclosed strategies. However, some funds have relatively low correlations between holdings and investor returns.

    pdf235p khanhchilam 29-03-2013 25 8   Download


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