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Investigational arm
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Relapsed or refractory follicular lymphoma (rrFL) is an incurable disease associated with shorter remissions and survival after each line of standard therapy. Many promising novel, chemotherapy-free therapies are in development, but few are licensed as their role in current treatment pathways is poorly defined.
13p
vishanshan
27-06-2024
1
1
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This paper focuses on investigating the driving torques of industrial robot arm joints by using the topology optimization algorithm for its links. Structural optimization criteria focus on reducing the mass of links in particular and the total mass of the system in general. Preliminary results show that there is a change in driving torques in a direction favorable for the operation of the joints when total mass of robot decreases for any trajectory.
12p
dathienlang1012
03-05-2024
4
1
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This study aims to assess the efficacy of CT-guided splanchnic nerve neurolysis in alleviating pain associated with malignancies in the upper abdominal viscera. A single-arm investigation involved 20 patients diagnosed with upper abdominal visceral malignancies and experiencing pain with a VAS ≥ 7.
7p
visergey
14-03-2024
4
1
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The prognosis of patients with previously treated advanced gastric or gastroesophageal junction (GEJ) cancer remains poor. Given the robust development of immunotherapy and targeted therapy during the last decades, we aimed to investigate if the combination of traditional second-line chemotherapy with sintilimab and apatinib could bring survival benefits for these patients.
10p
vischultz
20-10-2023
1
1
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The prognosis of patients with advanced biliary tract cancer (BTC) who have progressed on gemcit‑abine plus cisplatin is dismal. Trifluridine/tipiracil (FTD/TPI) and irinotecan have proven efficacy in different gastroin‑ testinal malignancies. We therefore hypothesized that this combination might improve the therapeutic outcome in patients with BTC after failure of first-line treatment.
12p
visharma
20-10-2023
2
2
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Prehabilitation with exercise interventions during neoadjuvant chemotherapy (NACT) is effective in reducing physical and psychosocial chemotherapy-related adverse events in patients with cancer. The aim of the study here described is to investigate if supervised exercise with high-intensity aerobic and resistance training during NACT can improve tumour reduction in patients with breast cancer.
17p
vioracle
29-09-2023
4
2
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To evaluate the nutritional status of patients before thyroid surgery at the Thyroid Surgery Department, National Hospital of Endocrinology in 2022. Methods: This was a cross-sectional study on 163 patients before thyroid surgery. Nutritional status of the patients was investigated using body mass index (BMI), midupper arm circumference (MUAC), and subjective global assessment (SGA).
7p
viwhitewolf
11-07-2023
5
2
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This thesis contributes to three distinct areas. Firstly, it explores whether risk management has become the fifth arm of working capital. Secondly, it tests if the determinants of working capital affect the profitability of an organisation. Finally, it investigates the influence of working capital on corporate ratings. There is a significant contribution to the finance literature in these three different areas. In addition, there are methodological advances in this area.
218p
runthenight04
02-02-2023
4
1
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Operating an object by generating stable hand-grip force during static or dynamic posture control of the upper extremities simultaneously is an important daily activity. Older adults require different attentional resources during grip strength control and arm movements. However, the impact of aging and reaching movements on precise grip strength and stability control among older adults is not well understood. This study investigated the impact of aging and reaching movements on grip strength and stability control in both hands of the upper extremities.
12p
vinobelprisen
26-03-2022
17
4
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To investigate whether transmuscular quadratus lumborum block (TQLB) combined with oxycodonebased patient-controlled intravenous analgesia (PCIA) compared with sufentanil-based patient-controlled intravenous analgesia could reduce postoperative pain and opioid consumption in patients undergoing laparoscopic hepatectomy.
10p
vidietmarhopp
28-12-2021
7
0
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According to current guidelines, treatment of patients with hepatic oligometastasis in pancreatic cancer is not reflected and systemic chemotherapy is recommended in those patients. Retrospective data suggest beneficial outcomes in patients with hepatic oligometastasis, though prospective data from clinical trials addressing this particular patient group is not available.
11p
vimahuateng
26-11-2021
9
1
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The results of a systematic study of spiro-cyclotri/tetraphosphazenes with ferrocenyl pendant arm on the basis of correlation between structural parameters were presented. The main parameters were obtained from Xray crystallography and 31P NMR results in order to investigate the relationship between the δPspiro shift values and endocyclic and exocyclic NPN bond angles, and electron density transfer parameters.
16p
tudichquannguyet
29-11-2021
10
1
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OptimalTTF-2 is a randomized, comparative, multi-center, investigator-initiated, interventional study aiming to test skull remodeling surgery in combination with Tumor Treating Fields therapy (TTFields) and best physicians choice medical oncological therapy for first recurrence in glioblastoma patients.
8p
vimahuateng
26-11-2021
10
1
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We conducted a single-arm phase II trial to investigate the short-term efficacy and safety of apatinib combined with oxaliplatin and S-1 in the treatment of unresectable gastric cancer.
8p
vimahuateng
26-11-2021
3
1
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This investigator-initiated, open-label, single-arm, single-institute study was conducted to investigate the effectiveness of induction combination chemoradiotherapy and long-term maintenance therapy with temozolomide (TMZ) plus interferon (IFN)-β for glioblastoma.
12p
vimahuateng
26-11-2021
7
0
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Diclofenac sodium (DS), a potent inhibitor of cyclooxygenase, reduces the release of arachidonic acid and formation of prostaglandins. Being a nonsteroid drug that shows antiinflammatory action, the possible side effects of fetal DS administration gain importance in public and medical applications. Herein, the effects of DS administration (1 mg/kg) during gestational days 5–20 were investigated on the performance of Wistar rat pups in a variety of behavioral tasks.
9p
thiencuuchu
27-11-2021
9
1
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Replantation in the upper extremity is a well-established microsurgical procedure. Many have reported patients’ satisfaction and functional measurements. The aim was to investigate the long time consequences as activity limitations in hand/arm, the general health and cold sensitivity after a replantation or revascularization in the upper extremity and to examine if sense of coherence (SOC) can be an indicator for rehabilitation focus.
8p
viannito2711
20-04-2021
16
2
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Cold sensitivity is a common complaint following hand injuries. Our aim was to investigate long-term self-reported cold sensitivity, and its predictors and the importance of sense of coherence (SOC), 8 years after a hand injury as well as in patients treated for Hand Arm Vibration Syndrome (HAVS) during the same time period.
9p
viannito2711
20-04-2021
8
2
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Knowledge of factors associated with chronic pain is necessary for preventive strategies. The present study investigates biopsychosocial differences, with specific focus on rate of force development (RFD) and work ability, between workers with and without chronic upper limb pain.
11p
vioregon2711
22-02-2021
6
2
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There is no study concerning safety and accuracy of pedicle screw placement in Marfan syndrome. The objective of this study is to investigate accuracy and safety of pedicle screw placement in scoliosis associated with Marfan syndrome.
6p
vitennessee2711
02-02-2021
10
2
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