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Ion channels
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In recent times many research activities have been carried out to prove the metal ion detection ability of Schiff bases. [13,14] In the present study, a new Schiff base has been synthesized from 5-bromo-2- hydroxybenzaldehyde and naphthalene-1,8-diamine and it is complexated with Co(II), Ni(II), Cu(II) and Zn(II) ions. The biological application of all the compounds has been analyzed and metal ions recognition property of the Schiff base has also been studied.
16p
dianmotminh02
03-05-2024
5
1
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Part 1 book "Anaesthesia science" includes content: Pharmacokinetic principles, pharmacodynamics, pharmacogenomics, receptors and second messenger systems, anaphylaxis, reflections on chirality, ion channels, immunosuppression, use and abuse of antibiotics, inflammation and immunity.
208p
zizaybay1101
30-04-2024
3
2
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Ebook "Nitric oxide in plants: Metabolism and role in stress physiology" covers the key features of nitric oxide (NO) in plants. Comprising nine chapters, Part I highlights its metabolism and identification in plants. Part II, which consists of eight chapters, focuses on the chemical, physical and biochemical properties of the NO molecule and its derivatives; on its functional role and mode of action; and on its signaling and interaction with phytohormones, mineral nutrients, biomolecules, ions and ion channels in plants under abiotic stresses.
310p
manmanthanhla0201
26-02-2024
3
1
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Ebook "Ion channels (Topics in medicinal chemistry, Volume 3)" play a vital role in basic physiological functions such as generation of electrical activity in nerves and muscle, control of cardiac excitability, intracellular signaling, hormone secretion, cell proliferation and many other biological processes. Because of their prevalence and the critical role they play in virtually all tissue types and organs, ion channels are also involved in a number of pathophysiological conditions. The aim of this volume is to review recent advances in the field of ion channel related diseases.
177p
manmanthanhla0201
27-02-2024
7
1
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Ebook Biomolecular simulations in structure-based drug discovery - Part 2 includes content: Ion channel simulations, understanding allostery to design new drugs, molecular dynamics applications to GPCR ligand design,…and other contents.
186p
longtimenosee03
01-02-2024
0
0
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Ebook "Ion channels and plant stress responses" reviews the molecular and physiological properties of ion channels in relation to their functional role in plant stress responses and presents novel hypotheses on mechanisms underlying the encoding and transduction of stress stimuli in plants. This volume focuses on the crucial roles of different types of ion channel in plant stress responses.
242p
tachieuhoa
28-01-2024
5
2
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Part 1 book "Pellock’s pediatric epilepsy" includes content: Pathophysiology of seizures in the developing brain; ion channels, membranes, and molecules in epilepsy and neuronal excitability; mutations in epilepsy - a network and neurodevelopmental perspective; metabolic and pharmacologic consequences of seizures; neuropathologic substrates of epilepsy.... and other contents.
580p
oursky03
28-08-2023
2
1
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Vertical organic field-effect transistors (VOFETs) provide an advantage over lateral ones with respect to the possibility to conveniently reduce the channel length. This is beneficial for increasing both the cut-off frequency and current density in organic field-effect transistor devices.
14p
viberbers
09-08-2023
5
3
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This project is focused on studying the biological effects of low-power RF radiation on the expression and function of mechanosensitive ion channel protein (Piezo-1). To evaluate the effects of long-term exposures, cells were exposed at the frequency of 1800 MHz and power of 17 dBm for a period of 2 and 4 hrs using the transverse electromagnetic (TEM) cell exposure system. To study the effects of short-term RF radiation (10 min), exposures emitted from the mobile phone headset at the frequency of 845 MHz and powers of -15 dBm and -5 dBm were applied to cell cultures.
141p
runthenight04
02-02-2023
2
2
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The thesis is structured as follows: In Chapter 1, the scientific literature is summarized within the scope of this study. Chapter 2 provides a comprehensive overview of the principles of the applied computational approaches in this study. Chapter 3 identifies the important residues of the LsIA/α7 nAChR complex that affect the interactions between the toxin and the membrane protein due to C-terminal carboxylation of LsIA. The effects of C-terminal modification of LsIA on interactions with α3β2 nAChR, involved in cardiovascular diseases, were also investigated in Chapter 4.
234p
runthenight04
02-02-2023
6
2
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Cyclic nucleotide-gated channels (CNGCs) are ligand-gated calcium signaling channels, play vital biological functions. Nonetheless, the CNGC gene families have not been well studied in Brassicaceae which includes commercially important and evolutionary model crops. Here, using in silico approaches, we recognized 414 CNGC genes in sixteen sequenced genomes of Brassicaceae species, which represent 10 genera of 8 tribes, ranging between 10‒51 genes.
53p
lyhuyenthu
31-01-2023
8
2
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This project "Examining changes in sensitivity and functionality of mechanosensitive ion channel protein Piezo 1 exposed to Low-Level Radiofrequency Radiation" is focused on studying the biological effects of low-power RF radiation on the expression and function of mechanosensitive ion channel protein (Piezo-1). To evaluate the effects of long-term exposures, cells were exposed at the frequency of 1800 MHz and power of 17 dBm for a period of 2 and 4 hrs using the transverse electromagnetic (TEM) cell exposure system.
141p
runordie3
06-07-2022
6
1
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A major challenge in the treatment of liver cancer is that a large proportion of patients fail to achieve long-term disease control, with death from liver cancer cell migration and invasion. Acid-sensitive ion channel 1α (ASIC1α) is involved in the migration, invasion, and proliferation of liver cancer cells.
15p
viangelamerkel
27-07-2022
6
2
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Epinephrine is a first-line drug for cardiopulmonary resuscitation, but its efficacy in the treatment of bupivacaine-induced cardiac toxicity is still in question. We hypothesized that epinephrine can reverse cardiac inhibition of bupivacaine by modulating ion flows through the ventricular myocyte membrane channels of rats.
8p
viisaacnewton
25-04-2022
10
1
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Sevoflurane potently enhances glycine receptor currents and more modestly decreases NMDA receptor currents, each of which may contribute to immobility. This modest NMDA receptor antagonism by sevoflurane at a minimum alveolar concentration (MAC) could be reciprocally related to large potentiation of other inhibitory ion channels.
7p
viisaacnewton
26-04-2022
12
1
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Over the last few decades intensive studies have been carried out on the molecular targets mediating general anesthesia as well as the effects of general anesthetics. The γ-aminobutyric acid type A receptor (GABAAR) has been indicated as the primary target of general anaesthetics such as propofol, etomidate and isoflurane, and sedating drugs including benzodiazepines and barbiturates.
10p
viisaacnewton
26-04-2022
12
1
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Ion channels play a crucial role in the development of ischemic brain injury. Recent studies have reported that the blockade of various types of ion channels improves outcomes in experimental stroke models. Amiodarone, one of the most effective drugs for life-threatening arrhythmia, works as a multiple channel blocker and its characteristics cover all four Vaughan-Williams classes.
7p
vampires36
30-12-2021
15
1
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Plants evolved from long-term adaptation to form regulatory mechanisms of perception, transduction, and response to stresses. The CBL–CIPK signaling system is a basic calcium sensor that plays an important role in sensing adverse environmental stimuli. CBLs can perceive and bind Ca2+ under adversity and then specifically interact with CIPKs. The activated CBL–CIPK complex phosphorylates downstream target proteins (such as ion channels and transporters), or regulates transcription factors and stress responsive genes.
10p
tudichquannguyet
29-11-2021
6
1
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The M2 protein of the influenza A virus, responsible for flu, is a homotetramer transmembrane protein, forming a transmembrane ion channel, where His 37s act as pH sensors and Trp 41s and Asp 44s act as channel gates. Opening of this channel leads to transfer of virus RNA into the human host. Thus, blocking this transfer is an important pharmaceutical strategy to stop infection. As a result of viral drug resistance, commercially available channel inhibitors, rimantadine (RIM) and amantadine (AMA), are not as effective as they used to be.
17p
tudichquannguyet
29-11-2021
13
1
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The cyclic nucleotide-gated ion channel (CNGC) family affects the uptake of cations, growth, pathogen defence, and thermotolerance in plants. However, the systematic identification, origin and function of this gene family has not been performed in Brassica oleracea, an important vegetable crop and genomic model organism.
18p
vilarryellison
29-10-2021
5
0
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