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Kinesin Eg5
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Trong nghiên cứu này, một mô hình 2D-QSAR về mối liên hệ giữa các chất ức chế và thụ thể Eg5 đã được chúng tôi xây dựng dựa trên thuật toán bình phương tối thiểu từng phần (PLS), với tập xây dựng gồm 74 chất và tập kiểm tra bao gồm 18 chất.
7p
viengels
25-08-2023
6
2
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Cancer is one of the main global health problems. In order to develop novel antitumor agents, we synthesized 3,4-dihydropyrimidine-2(1H)-one (DHPM) and 2,6-diaryl-substituted pyridine derivatives as potential antitumor structures and evaluated their cytotoxic effects against several cancer cell lines. An easy and convenient method is reported for the synthesis of these derivatives, employing cobalt ferrite (CoFe 2 O4 @SiO2 -SO3 H) magnetic nanoparticles under microwave irradiation and solvent-free conditions.
20p
tudichquannguyet
29-11-2021
7
1
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Breast cancer is a complex heterogeneous disease and is one of the leading causes of death among women. In addressing the need for treatments of this life-threatening illness, we studied 3,4-dihydropyrimidin-2 (1H)-one (or thione) derivatives (DHPMs), a class of inhibitor molecules of the Eg5 motor spindle protein that shows pronounced antitumor activity against several cancer cell lines.
15p
vialabama2711
21-09-2020
20
1
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