Laboratory guidelines

Clinical laboratories implement a variety of measures to classify somatic sequence variants and identify clinically significant variants to facilitate the implementation of precision medicine. To standardize the interpretation process.

14p vibransone 28-03-2024 1 1   Download

Clinical genetics laboratories have recently adopted guidelines for the interpretation of sequence variants set by the American College of Medical Genetics (ACMG) and Association for Molecular Pathology (AMP). The use of in silico algorithms to predict whether amino acid substitutions result in human disease is inconsistent across clinical laboratories.

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The uptake of exome/genome sequencing has introduced unexpected testing results (incidental findings) that have become a major challenge for both testing laboratories and providers. While the American College of Medical Genetics and Genomics has outlined guidelines for laboratory management of clinically actionable secondary findings, debate remains as to whether incidental findings should be returned to patients, especially those representing pediatric populations.

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Part 1 book "Koneman’s color atlas and textbook of diagnostic microbiology" includes content: Introduction to microbiology part I - the role of the microbiology laboratory in the diagnosis of infectious diseases; guidelines for the collection, transport, processing, analysis, and reporting of cultures from specific specimen sources; laboratory diagnosis by immunologic methods; molecular microbiology; medical bacteriology - taxonomy, morphology, physiology, and virulence; the enterobacteriaceae,... and other contents.

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Part 1 book "Laboratory animals - regulations and recommendations for the care and use of animals in research" includes content: Global guiding principles - a tool for harmonization; oversight of research animal welfare in the united states; canada’s oversight of animal ethics and care in science; laboratory animal legislation in latin america; the european framework on research animal welfare regulations and guidelines; israeli legislation and regulation on the use of animals in biological and medical research.

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Part 2 book "Laboratory animals - regulations and recommendations for the care and use of animals in research" includes content: Animal experimentation in africa - legislation and guidelines; laws, regulations, and guidelines governing research animal care and use in india; oversight of animal research in China; laws, regulations, guidelines, and principles pertaining to laboratory animals in far east asia; laws, regulations, guidelines, and principles pertaining to laboratory animals in Southeast Asia; laboratory animals regulations and recommendations - australia and New Zealand.

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Part 2 book "Avian influenza and newcastle disease - A field and laboratory manual" includes content: Molecular diagnosis of avian influenza, clinical traits and pathology of newcastle disease infection and guidelines for farm visit and differential diagnosis, conventional diagnosis of newcastle disease virus infection, molecular diagnosis of newcastle disease virus,.... and other contents.

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Part 1 book "Animal welfare (Vol 2 - The welfare of laboratory animals) includes content: Animal welfare - an introduction; research, animals and welfare; regulations, alternatives and guidelines; infections in laboratory animals - Importance and control; housing, care and environmental factors, nutrition and animal welfare, experimental procedures - General principles and recommendations..... and other contents.

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Part 1 book "Animal models in toxicology" includes content: Primates, the minipig, alternative species, clinical pathology of laboratory animals, telemetry in nonclinical drug safety assessment studies, molecular imaging techniques in laboratory animals, genetically modified animal models, model selection and scaling; susceptibility factors, laws, regulations, and guidelines for animal care and use in research necropsy and gross pathology, immunology laboratory endpoints for assessment of immunomodulators in preclinical studies and case studies using anti CD3 mab in cynomolgus monkey.

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Part 1 book "Mosby's manual of diagnostic and laboratory tests" includes content: Guidelines for proper test preparation and performance, blood studies, electrodiagnostic tests, endoscopic studies, fluid analysis studies, manometric studies.

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Part 2 book "Vertebrate embryogenesis - Embryological, cellular, and genetic methods" includes content: Assisted reproductive technology in nonhuman primates, ciona genetics, reptile embryology, mutant generation in vertebrate model organisms by tilling, laboratory guidelines for animal care, keeping two animal systems in one lab – a frog plus fish case study

293p oursky05 20-09-2023 4 1   Download

We developed and validated an algorithm that uses combinations of extractable electronic-health-record (EHR) indicators (diagnosis codes, orders for laboratories, medications, and referrals) that denote widelyrecommended clinician practice behaviors: attention to overweight/obesity/body mass index alone (BMI Alone), with attention to hypertension/other comorbidities (BMI/Medical Risk), or neither (No Attention).

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The aim of the 2018 Intercomparison exercise implemented by the Primary Standard Dosimetry Laboratory (PSDL) of Australian Radiation Protection and Nuclear Safety Agency (ARPANSA) collaborated with IAEA is to assess the capabilities of the dosimetry services in participating member states in Asia and the Pacific region for the personal dose equivalent, Hp(10), in photon (gamma and X-ray) fields, thus supporting them to achieve a more accurate dosimetry service and to provide them with guidelines to improve the performance of the existing dosimetry services.

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How to Define and Determine Reference Intervals in the Clinical Laboratory; Approved Guideline — Second Edition (NCCLS document C28-A2) is written for users of diagnostic laboratory tests. It offers a protocol for determining reference intervals that meet the minimum requirements for reliability and usefulness.

59p tailieucuibap 19-06-2022 17 1   Download

Quantitative bacterial culture (QBC) is the gold standard for diagnosing canine urinary tract infections. Current guidelines recommend QBC within 24h of urine collection and that unpreserved urine is refrigerated until culture. However, temperature-controlled transport is rarely feasible, indicating a need for alternative storage during transport of urine from primary veterinary practices to the microbiology laboratory.

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The American College of Medical Genetics and American College of Pathologists (ACMG/AMP) variant classification guidelines for clinical reporting are widely used in diagnostic laboratories for variant interpretation. The ACMG/AMP guidelines recommend complete concordance of predictions among all in silico algorithms used without specifying the number or types of algorithms.

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Sodium hypochlorite is extensively used as a disinfectant in the health care industry for more than 150 years. There are lots of misconceptions are there even to this day regarding the dilution and time of exposure required for its disinfection action. National guideline on Biomedical waste published by the Ministry of Government of India in its recommendations on Biomedical Waste (BMW) rule of 2016 had suggested the use of 10 % Sodium hypochlorite which was later corrected as typographical error and changed to 1 % which is now followed in the BMW Rule – 2018.

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Sepsis is a major cause of morbidity and mortality among neonates. Neonatal sepsis may be categorized as early-onset or late-onset. Clinical manifestations of neonatal sepsis are non-specific, therefore, clinical diagnosis of sepsis is difficult and laboratory help is required. Present study was done to evaluate three different methods in diagnosis of neonatal sepsis. 3 ml of venous blood was collected employing strict aseptic precautions from all babies admitted to the NICU in our hospital during the study period. 2 ml of blood was aseptically added to BacT/ ALERT PF culture bottle.

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Neonatal sepsis is defined as a bacterial infection of the blood in an infant younger than 4 weeks of age. Blood cultures remain the mainstay of laboratory diagnosis of bloodstream infections (BSIs) in infants. The knowledge of bacteriological profile and its antibiotic sensitivity patterns is of immense help in saving lives of neonates with septicaemia.

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us is one of the major samples received in the Microbiology laboratory for culture and sensitivity. Though the bacterial profile from pus samples remain similar in various studies, the inadvertent use of antibiotics has lead to the emergence of various drug resistant pathogens, which in turn acts as a great challenge to the health services.

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