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Luteinizing hormone releasing hormone
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Prostatectomy and regional radiotherapy were performed and goserelin, a luteinizing hormone-releasing hormone (LHRH) analog, had been started because of disease progression. Castration-resistant progressive disease developed, and enzalutamide was added. A decrease of the prostate-specific antigen (PSA) level was achieved.
4p
viintuit
26-09-2023
1
0
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Mục tiêu của nghiên cứu này nhằm đánh giá ảnh hưởng của thời gian kích thích hormone với domperidone (DOM), luteinizing hormone releasing hormone analog (LHRHa) và human chorionic gonadotropin (HCG) lên đặc tính sinh hóa của dịch tương cá chẽm mõm nhọn Psammoperca waigiensis sau thời gian tiêm 72h. Cá đực được tiêm ở gốc vây bụng với 0.9% nước muối sinh lý (đối chứng) hoặc tiêm một liều đơn DOM (20 mg/kg khối lượng cá (KL)) hoặc LHRHa (20, 50, hoặc 80 µg/kg KL) hoặc HCG (500, 1000, hoặc 1500 IU/kg KL).
9p
gaocaolon10
30-01-2021
36
2
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Triple negative breast cancer (TNBC) is a distinct subtype of breast cancer burdened with a dismal prognosis due to the lack of effective therapeutic agents. Receptors for LHRH (luteinizing hormone-releasing hormone) can be successfully targeted with AEZS-108 [AN-152], an analog of LHRH conjugated to doxorubicin.
12p
vilisa271
22-09-2020
9
0
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Luteinizing hormone-releasing hormone receptor (LHRHr) represents a promising therapeutic target for treating sex hormone-dependent tumors. We coupled cecropin B, an antimicrobial peptide, to LHRH’, a form of LHRH modified at carboxyl-terminal residues 4–10, which binds to LHRHr without interfering with luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion.
9p
vinaypyidaw2711
26-08-2020
12
1
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Although brucea javanica oil liposomes (BJOLs) have been used clinically to treat ovarian cancer, its clinical efficacy is often limited by systemic side effects due to non-specific distribution. Luteinizing hormone releasing hormone receptor (LHRHR) is overexpressed in most ovarian cancers but negligibly expressed in most of the other visceral organs.
13p
vimale2711
25-08-2020
11
1
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Orchidectomy is currently the preferred method to induce bone loss in preclinical male osteoporosis model. Gonadotropin-releasing hormone (GnRH) agonists used in prostate cancer treatment can induce testosterone deficiency but its effects on bone in preclinical male osteoporosis model are less studied.
9p
vinasaki2711
12-11-2019
14
2
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Nghiên cứu này được thực hiện nhằm đánh giá ảnh hưởng của hormone ngoại sinh hCG (human Chorionic Gonadotropin), LHRH-A (Luteinizing Hormone-releasing hormone analog) kết hợp chất kháng dompamine (Domperidon-DOM) đến thành phần sinh hóa tinh sào cá dìa (Siganus guttatus) 1+ tuổi nuôi trong ao đất tại Khánh Hòa.
6p
vihasaki2711
12-11-2019
41
0
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Gonadotropin releasing hormone receptor (GnRHR) is secreted from hypothalamus and delivered to the anterior pituitary via the hypophyseal portal circulation where it binds to the GnRHR on the surface of gonadotropes triggering the synthesis and secretion of the gonadotropins, follicle stimulating hormone (FSH) and luteinizing hormone (LH). In the female, LH stimulates the production of androgens by the thecal cells that surround the growing ovarian follicle.
582p
ti_du_hoang
15-08-2012
63
5
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Chương 9. THUỐC TÁC ĐỘNG LÊN HỆ SINH DỤC VÀ TIẾT NIỆU 9.1. Nội tiết tố sinh dục Các họat động trong chu kỳ sinh dục được điều khiển bởi hệ thần kinh và nội tiết theo cơ chế phản hồi âm tính (negative feedback) hay điều khiển ngược. Từ hạ tầng thị giác, GnRH (gonadotropin releasing hormone) – sinh dục hưnh phấn tố được chuyển đến não thùy trước kích thích sự phân tíết FSH (follicle stimulatin hormone ) – nang noãn hu6ng phấn tố và LH (luteinizing hormone ) hoàng thể hưng phấn tố. Dưới tác động của FSH,...
26p
biodoc
05-09-2011
188
34
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Gonadotropin-releasing hormone antagonists (GnRH-nt) available for clinical use are GnRH molecules with amino acid modifications in positions 1, 2, 3, 6, and 10. They are not associated with the histaminic-release effects of previous compounds (1). These compounds immediately block GnRH receptor in a competitive fashion (2). They decrease the luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion within a period of eight hours. Inhibition of LH secretion is more important than FSH.
24p
lananhanh123
27-08-2011
49
3
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Diethylstilbestrol (DES) acting as an estrogen at the level of the hypothalamus to downregulate hypothalamic luteinizing hormone (LH) production results in decreased elaboration of testosterone by the testicle. For this reason, orchiectomy is equally as effective as moderate-dose DES, inducing responses in 80% of previously untreated patients with prostate cancer but without the prominent cardiovascular side effects of DES, including thrombosis and exacerbation of coronary artery disease.
4p
konheokonmummim
03-12-2010
71
2
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Role of the hypothalamic-pituitary-gonadal axis in the etiology of amenorrhea. Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus stimulates follicle-stimulating hormone (FSH) and luteinizing hormone (LH) secretion from the pituitary to induce ovarian folliculogenesis and steroidogenesis. Ovarian secretion of estradiol and progesterone controls the shedding of the endometrium, resulting in menses and, in combination with the inhibins, provides feedback regulation of the hypothalamus and pituitary to control secretion of FSH and LH.
5p
konheokonmummim
30-11-2010
87
3
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