Macromolecular structure

Ebook "DNA helicases and DNA motor proteins" is to provide the first systematic overview of structure, function and regulation of DNA helicases and related molecular motors. By integrating the knowledge obtained through the diverse technical approaches ranging from single-molecule biophysics to cellular and molecular biological studies the editors aim to provide a unified view on how helicases function in the cell, are regulated in response to different cellular stresses and are integrated into large macromolecular assemblies to form a complex and adaptive living system.

308p ladongphongthanh1008 22-04-2024 4 2   Download

Ebook "From single molecules to nanoscopically structured materials" principle relied on the defined functionalization of macromolecules and macromolecular assemblies. The basic idea was to chemically encode the building blocks, permitting better control of structure formation. The placement of ionic or hydrogen-bonding groups into well-defined positions, the definition of amphiphilic “patches” and the creation of directed as well as non-directed interactions have led to novel aggregate topologies in solution as well as on surfaces.

293p tudohanhtau1006 29-03-2024 2 1   Download

In ebook "Complex macromolecular systems II (Advances in polymer science, Volume 228)" the combination and interplay of these well-balanced “internal fields” with “external fields” such as mechanical, electrical, magnetic, electromagnetic, and/or the interactions with surfaces are a powerful tool to create defect-free and perfectly ordered macromolecular structures on a macroscopic scale, leading to new material properties, processes, and applications.

221p manmanthanhla0201 26-02-2024 4 1   Download

Ebook "Hierarchical macromolecular structures: 60 years after the Staudinger Nobel Prize II" enjoys a long standing tradition and good reputation in its community. Each volume is dedicated to a current topic and each review critically surveys one aspect of that topic, to place it within the context of the volume.

460p nhanphanguyet 28-01-2024 6 2   Download

Ebook "Protein NMR: Methods and protocols" covers state-of-the-art applications of solid-state and solution nuclear magnetic resonance( NMR) spectroscopy to study protein structure, dynamics and interactions. Chapters detail various aspects of data acquisition and processing, determination of the structure, multi-timescale dynamics of entities ranging from individual proteins to large macromolecular complexes to intact viral assemblies.

448p lucchinguyen 28-12-2023 11 2   Download

Ebook "Structure and dynamics of confined polymers" provide insight on biological processes involving confinement and form a basis for new biotechnological applications using polymers. In his paper Edmund DiMarzio asks: What is so special about polymers? Why are polymers so prevalent in living things? The chemist says the reason is that a protein made of N amino acids can have any of 20 different kinds at each position along the chain, resulting in 20 N different polymers, and that the complexity of life lies in this variety.

393p loivantrinh 29-10-2023 8 4   Download

Part 1 book "Cell biology" includes content: Introduction to cells, evolution of life on earth, chemical and physical background, biophysical principles, macromolecular assembly, chromosome organization, DNA packaging in chromatin and chromosomes, nuclear structure and dynamics, gene expression, eukaryotic RNA processing,... and other contents.

310p oursky04 14-09-2023 3 3   Download

Computational models of protein structures were proved to be useful as search models in Molecular Replacement (MR), a common method to solve the phase problem faced by macromolecular crystallography. The success of MR depends on the accuracy of a search model. Unfortunately, this parameter remains unknown until the final structure of the target protein is determined.

12p viwyoming2711 16-12-2020 10 0   Download

Structural comparison of protein-protein interfaces provides valuable insights into the functional relationship between proteins, which may not solely arise from shared evolutionary origin. A few methods that exist for such comparative studies have focused on structural models determined at atomic resolution, and may miss out interesting patterns present in large macromolecular complexes that are typically solved by low-resolution techniques.

12p vikentucky2711 26-11-2020 12 1   Download

Proteins interact with a variety of other molecules such as nucleic acids, small molecules and other proteins inside the cell. Structure-determination of protein-protein complexes is challenging due to several reasons such as the large molecular weights of these macromolecular complexes, their dynamic nature, difficulty in purification and sample preparation.

6p vikentucky2711 24-11-2020 15 1   Download

The Electron Microscopy DataBank (EMDB) is growing rapidly, accumulating biological structural data obtained mainly by electron microscopy and tomography, which are emerging techniques for determining large biomolecular complex and subcellular structures.

9p vikentucky2711 24-11-2020 16 2   Download

Cryo-electron tomography (cryo-ET) enables 3D imaging of macromolecular structures. Reconstructed cryo-ET images have a “missing wedge” of data loss due to limitations in rotation of the mounting stage.

14p vioklahoma2711 19-11-2020 11 0   Download

Cryo-electron tomography is an important tool to study structures of macromolecular complexes in close to native states. A whole cell cryo electron tomogram contains structural information of all its macromolecular complexes. However, extracting this information remains challenging, and relies on sophisticated image processing, in particular for template-free particle extraction, classification and averaging.

13p vioklahoma2711 19-11-2020 9 0   Download

Advances in computing have enabled current protein and RNA structure prediction and molecular simulation methods to dramatically increase their sampling of conformational spaces. The quickly growing number of experimentally resolved structures, and databases such as the Protein Data Bank, also implies large scale structural similarity analyses to retrieve and classify macromolecular data.

8p vioklahoma2711 19-11-2020 8 0   Download

Single-particle cryo-electron microscopy (cryo-EM) has become a mainstream tool for the structural determination of biological macromolecular complexes. However, high-resolution cryo-EM reconstruction often requires hundreds of thousands of single-particle images.

10p viflorida2711 30-10-2020 11 1   Download

Single-particle analysis of electron cryo-microscopy (cryo-EM) is a key technology for elucidation of macromolecular structures. Recent technical advances in hardware and software developments significantly enhanced the resolution of cryo-EM density maps and broadened the applicability and the circle of users.

10p viconnecticut2711 29-10-2020 11 1   Download

Cryo-electron microscopy (cryo-EM) has become a widely used tool for determining the structures of proteins and macromolecular complexes. To acquire the input for single-particle cryo-EM reconstruction, researchers must select hundreds of thousands of particles from micrographs.

14p vicoachella2711 27-10-2020 8 0   Download

An important task of macromolecular structure determination by cryo-electron microscopy (cryo-EM) is the identification of single particles in micrographs (particle picking). Due to the necessity of human involvement in the process, current particle picking techniques are time consuming and often result in many false positives and negatives.

26p vijisoo2711 27-10-2020 6 0   Download

The double-stranded RNA-binding motif (dsRBM) is anabbbafold with a well-characterized function to bind structured RNA molecules. This motif is widely distributed in eukaryotic proteins, as well as in proteins from bac-teria and viruses. dsRBM-containing proteins are involved in processes ran-ging from RNA editing to protein phosphorylation in translational control and contain a variable number of dsRBM domains.

0p awards 06-04-2013 24 1   Download

Whatever the context, be it solid, liquid, or some transitionary setting, materials science seeks an understanding of a material's macromolecular structure and properties by drawing on knowledge of its atomic and molecular constituents. Until recently, the term ''materials science'' was used primarily to denote empirical study, fundamental research, synthesis, a

6p anhnangmuahe2013 15-03-2013 52 2   Download