Magnetic material engineering in biology

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  • Normally, any ferromagnetic or ferrimagnetic material undergoes a transition to a paramagnetic state above its Curie temperature. Superparamagnetism is different from this standard transition since it occurs below the Curie temperature of the material. Superparamagnetism occurs in nanoparticles which are single domain. This is possible when their diameter is below 3–50 nm, depending on the materials.

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  • Since its first implementation by Lauterbur [1], Magnetic Resonance Imaging (MRI) has become an important noninvasive imaging modality. MRI has found a number of applications in the fields of biology, engineering, and material science. Because it provides unique contrast between soft tissues (which is generally superior to that of CT) and high spatial resolution, MRI has revolutionized diagnostic imaging in medical science. An important advantage of diagnostic MRI as compared to CT is that the former does not use ionizing radiation....

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  • Here DNA has been used as templating and self-assembling reagent to grow the chain like nanostructure. We have designed the composite in such a fashion that we obtained optical and magnetic properties together in a single biological material. Optical properties characterized by UV–visible absorption, Circular Dichroism (CD) and their analysis show no denaturization of DNA. Transmission electron micrographs (TEM) indicate formation of chain like structure of the nanoparticles. Particles were functionalized with folic acid for labeling and treatment of cancer cell.

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