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Major intrinsic protein
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Radio-chemotherapy with 5-fluorouracil (5-FU) is the standard of care treatment for patients with colorectal can‑ cer, but it is only effective for a third of them. Despite our understanding of the mechanism of action of 5-FU, drug resistance remains a significant limitation to the clinical use of 5-FU, as both intrinsic and acquired chemoresistance represents the major obstacles for the success of 5-FU-based chemotherapy.
19p
vikolindagrabar
27-07-2022
5
1
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Aquaporins (AQPs) are integral membrane proteins from a larger family of major intrinsic proteins (MIPs) and function in a huge variety of processes such as water transport, plant growth and stress response. The availability of the whole-genome data of different cotton species allows us to study systematic evolution and function of cotton AQPs on a genome-wide level.
17p
visilicon2711
20-08-2021
7
1
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Stability is one of the most fundamental intrinsic characteristics of proteins and can be determined with various methods. Characterization of protein properties does not keep pace with increase in new sequence data and therefore even basic properties are not known for far majority of identified proteins.
9p
viansan2711
30-07-2021
14
1
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Aquaporins (AQPs), as members of the major intrinsic protein (MIP) superfamily, facilitated the permeation of water and other solutes and are involved in multiple biological processes. AQP family exists in almost all living organisms and is highly diversified in vertebrates in both classification and function due to genome wide duplication.
20p
vijeeni2711
30-06-2021
9
1
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Cataracts are defects of the lens that cause progressive visual impairment and ultimately blindness in many vertebrate species. Most cataracts are age-related, but up to one third have an underlying genetic cause.
10p
vilichoo2711
25-06-2021
10
1
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Cellular membranes are dynamic structures, continuously adjusting their composition, allowing plants to respond to developmental signals, stresses, and changing environments. To facilitate transmembrane transport of substrates, plant membranes are embedded with both active and passive transporters.
29p
vijichea2711
28-05-2021
11
1
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Alpha-helical transmembrane channel and transporter proteins play vital roles in a diverse range of essential biological processes and are crucial in facilitating the passage of ions and molecules across the lipid bilayer.
9p
viwyoming2711
16-12-2020
12
1
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It is promising, however, that a a majority of male and female respondents perceive social media as an enabler for women’s empowerment. This is coupled with the robust growth of social media usage among youth in the Arab region. If lessons are to be drawn from youth utilization of social media during the recent popular movements in the Arab world, then in light of the growing sense of empowerment today, the strong positive perceptions shown in our survey suggest that social media can continue to play an important role in empowering Arab women in the future. However, this will only...
71p
thamgiacongdong
02-05-2013
52
7
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The concentration in the large public company audit market is also unlikely to be reduced in the near term by midsize and smaller accounting firms because a significant majority is not interested in auditing large public companies and those that are interested face various challenges in expanding their capability to do so. Over 70 percent of midsize and smaller accounting firms indicated that they were not attempting to obtain large public company clients.
0p
tay_thi_le
19-02-2013
53
4
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Bonds of Blood and Honour” is an introductory adventure for A Game of Th rones RPG. It is structured around the “Noble House” campaign style. It is not completely scripted, and requires the GM to fl esh out certain details and make important decisions about some aspects of the plot. Additionally, it does not provide stat write-ups for the major NPCs, instead referring to the sample NPCs from the core rulebook. Note that the adventure is written for the d20-based Open Gaming rules, but includes the corresponding Tri-Stat System rules [italicised, in brackets], when appropriate.
24p
taisaocothedung
12-01-2013
54
2
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All voting takes place orally unless the chairman decides on a voting in writing or any person entitled to vote requests a voting in writing. A voting in writing takes place by means of unsigned ballot papers. Votes by acclamation are allowed unless one of the persons present and entitled to vote objects. If no absolute majority is reached by a vote taken with respect to the election of persons, a second vote shall be taken whereby the voters are not required to vote for the previous candidates. If, again, no one has gained an absolute majority of the votes,...
8p
quaivattim
04-12-2012
40
1
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Overall, the quality of SAR reporting has been quite good, indicating that insur- ance companies are well positioned to report to law enforcement several specific categories of suspected illicit activities relating to money laundering. In addition, they are equally poised to provide through SARs, information that may benefit the mission of state regulatory agencies. FinCEN analysts read and reviewed each of the 641 SARs filed by insurance com- panies between May 2, 2006 and May 1, 2007.
36p
thangbienthai
23-11-2012
47
5
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Bacterial biofilms are regarded to be the primary aetiological factor in the initiation of gingival inflammation and subsequent destruction of periodontal tissues (Offenbacher 1996) and three major specific pathogens have been repeatedly identified as etiologic agents, namely Aggregatibacter (Actinobacillus) actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg) and Tannerella forsythia (Tf) (Socransky et al. 1998).
28p
pt_1669
27-03-2012
400
145
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Genome-wide analysis of major intrinsic proteins in the tree plant Populus trichocarpa: Characterization of XIP subfamily of aquaporins from evolutionary perspective Anjali Bansal Gupta and Ramasubbu
28p
panasonic06
25-12-2011
49
3
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