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Manhattan plot
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Selection of interesting regions from genome wide association studies (GWAS) is typically performed by eyeballing of Manhattan Plots. This is no longer possible with thousands of different phenotypes. There is a need for tools that can automatically detect genomic regions that correspond to what the experienced researcher perceives as peaks worthwhile of further study.
8p
vicoachella2711
27-10-2020
8
0
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Over the last 10 years, there have been over 3300 genome-wide association studies (GWAS). Almost every GWAS study provides a Manhattan plot either as a main figure or in the supplement. Several software packages can generate a Manhattan plot, but they are all limited in the extent to which they can annotate genenames, allele frequencies, and variants having high impact on gene function or provide any other added information or flexibility.
5p
vicolorado2711
23-10-2020
18
0
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Genome-wide association studies (GWAS) are typically visualized using a two-dimensional Manhattan plot, displaying chromosomal location of SNPs along the x-axis and the negative log-10 of their p-value on the yaxis.
8p
vicolorado2711
22-10-2020
6
0
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