Module discovery

Neurodevelopmental disorders (NDDs) such as autism spectrum disorder, intellectual disability, developmental disability, and epilepsy are characterized by abnormal brain development that may affect cognition, learning, behavior, and motor skills. High co-occurrence (comorbidity) of NDDs indicates a shared, underlying biological mechanism.

14p vibransone 28-03-2024 5 2   Download

The rapid expansion of the available genomic data continues to greatly impact biomedical science and medicine. Fulfilling the clinical potential of genetic discoveries requires the development of therapeutics that can specifically modulate the expression of disease-relevant genes.

16p vioraclene 31-03-2024 3 2   Download

Ebook "Chemokines: Chemokines and their receptors in drug discovery" covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level,...

248p tudohanhtau1006 29-03-2024 1 1   Download

Ebook "Disruption of protein–protein interfaces: In search of new inhibitors" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces. The authors detail experimental and computational tools to tackle the subject and highlight the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs.

166p coduathanh1122 27-03-2024 2 1   Download

Ebook "Computational methods for GPCR drug discovery" looks at modern computational strategies and techniques used in GPCR drug discovery including structure and ligand-based approaches and cheminformatics.

437p lamquandat 28-12-2023 6 2   Download

Ebook "Drug target miRNA: Methods and protocols" provides a concise and technical discussion of recently developed approaches to overcome challenges, such as pharmacodynamics and pharmacokinetics difficulties, in miRNA drug discovery. These strategies cover anti-sense agents targeting miRNA that are applied in advanced formulations or are chemically optimized to increase delivery; small molecule miRNA modulators to overcome anti-sense agents’ limitations; general enhancers of miRNA maturation; and Argonaute 2 protein and its pharmacokinetic parameters.

318p lucchinguyen 28-12-2023 3 2   Download

We present the method of the HCMUS team pariticipating in Multimodal Person Discovery in Broadcast TV Task at the MediaEval Challenge 2016. There are two main tasks in our method. First we identify a list of potential characters of interest from all video clips. Each potential character is defined as a pair of face track, a sequence of face patches, and a name. We use OCR results and face detection to find potential characters.

4p viclerkmaxwel 16-02-2022 21 5   Download

Head and neck cancer (HNC) is the sixth most common cancer worldwide and therefore presents a global public health problem. There are no standard algorithms for the diagnosis and follow-up of the disease, and no effective current treatment approaches exist. Therefore, the discovery of new biomolecules and the design of new strategies to aid in early diagnosis is necessary, along with establishing prognostic factors of HNC.

12p thiencuuchu 27-11-2021 16 1   Download

Bioinformatic analyses have suggested their upregulation in leukemia/lymphoma, thymoma, pancreas, glioma, and glioblastoma, and downregulation in cervical, uterine, rectum, and colon cancers. However, every cancer type includes, at least, a subtype with high MEIS expression. In addition, studies have highlighted that MEIS proteins and associated factors may function as diagnostic or therapeutic biomarkers for various diseases.

28p thiencuuchu 27-11-2021 7 1   Download

There is considerable evidence that many complex traits have a partially shared genetic basis, termed pleiotropy. It is therefore useful to consider integrating genome-wide association study (GWAS) data across several traits, usually at the summary statistic level. A major practical challenge arises when these GWAS have overlapping subjects. This is particularly an issue when estimating pleiotropy using methods that condition the significance of one trait on the signficance of a second, such as the covariate-modulated false discovery rate (cmfdr).

15p vilarryellison 29-10-2021 3 0   Download

NipahVirus (NiV) is a zoonotic Virus which infects several animals and humans worldwide. Currently, there is no specific drug or vaccine to treat or control NiV infections. The present study is aimed to identify novel inhibitors of NiV from Indian medicinal plants. Glycoprotein was taken as target protein. Around 600 phytocompounds were taken from 10 Indian medicinal plants and subjected to Virtual Screening by using Libdock module from Discovery Studio 4.0. From these, the best 20 compounds were screened and evaluated for their Pharmacokinetic properties by using ADMETSAR and pKCSM tools.

14p trinhthamhodang9 16-12-2020 9 2   Download

Many variable selection techniques have been proposed for the clustering of gene expression data. While these methods tend to filter out irrelevant genes and identify informative genes that contribute to a clustering solution, they are based on criteria that do not consider the potential interactive influence among individual genes.

11p vikentucky2711 26-11-2020 9 1   Download

A number of membrane-anchored proteins are known to be released from cell surface via ectodomain shedding. The cleavage and release of membrane proteins has been shown to modulate various cellular processes and disease pathologies.

18p vioklahoma2711 19-11-2020 12 2   Download

Recently, the metabolite-likeness of the drug space has emerged and has opened a new possibility for exploring human metabolite-like candidates in drug discovery. However, the applicability of metabolite-likeness in drug discovery has been largely unexplored.

10p viflorida2711 30-10-2020 12 2   Download

Much effort has been devoted to the discovery of specific mechanisms between drugs and single targets to date. However, as biological systems maintain homeostasis at the level of functional networks robustly controlling the internal environment, such networks commonly contain multiple redundant mechanisms designed to counteract loss or perturbation of a single member of the network.

14p viconnecticut2711 29-10-2020 14 1   Download

The analysis of modular gene co-expression networks is a well-established method commonly used for discovering the systems-level functionality of genes. In addition, these studies provide a basis for the discovery of clinically relevant molecular pathways underlying different diseases and conditions.

13p viconnecticut2711 28-10-2020 11 1   Download

Non-coding RNAs (ncRNAs) are emerging as key regulators and play critical roles in a wide range of tumorigenesis. Recent studies have suggested that long non-coding RNAs (lncRNAs) could interact with microRNAs (miRNAs) and indirectly regulate miRNA targets through competing interactions.

13p vicoachella2711 27-10-2020 12 0   Download

Identifying transcriptional enhancers and other cis-regulatory modules (CRMs) is an important goal of post-sequencing genome annotation. Computational approaches provide a useful complement to empirical methods for CRM discovery, but it is critical that we develop effective means to evaluate their performance in terms of estimating their sensitivity and specificity.

15p vijisoo2711 27-10-2020 11 1   Download

Regulators of G protein signaling (RGS) proteins modulate G protein-coupled receptor (GPCR) signaling networks by terminating signals produced by active Gα subunits. RGS17, a member of the RZ subfamily of RGS proteins, is typically only expressed in appreciable amounts in the human central nervous system, but previous works have shown that RGS17 expression is selectively upregulated in a number of malignancies, including lung, breast, prostate, and hepatocellular carcinoma.

10p caothientrangnguyen 09-05-2020 10 0   Download

Ecdysteroids are hormones with an important role in the molting, reproduction and immunological defense of arthropods. Ecdysone Receptor (EcR) is a protein that belongs to the superfamily of nuclear receptors, widely studied for pesticide discovery. Currently, several non-steroidal molecules, belonging to the chemical group of diacilhydrazines (DAH), are commercially available for pest control. Such molecules are specific for lepidopteran or coleopteran pests. Hemipterans are important pests in most crops and many cases of pesticide resistance are reported.

10p chauchaungayxua1 04-12-2019 14 1   Download