Molecular oncology
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In neuro-oncology, the inclusion of tumor patients in the molecular tumor board has only become increasingly widespread in recent years, but so far there are no standards for indication, procedure, evaluation, therapy recommendations and therapy implementation of neuro-oncological patients. The present work examines the current handling of neuro-oncological patients included in molecular tumor boards in Germany.
9p vikoch 27-06-2024 1 1 Download
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Part 2 book "Molecular diagnostics - Fundamentals, methods, and clinical applications" includes content: DNA polymorphisms and human identifi cation, detection and identifi cation of microorganisms; molecular detection of inherited diseases, molecular oncology, DNA based tissue typing, quality assurance and quality control in the molecular laboratory.
303p muasambanhan10 06-04-2024 3 0 Download
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A comprehensive understanding of cancer has been furthered with technological improvements and decreasing costs of next-generation sequencing (NGS). However, the complexity of interpreting genomic data is hindering the implementation of high-throughput technologies in the clinical context: increasing evidence on gene–drug interactions complicates the task of assigning clinical significance to genomic variants.
15p vibransone 28-03-2024 3 2 Download
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High-grade serous ovarian cancer (HGSOC) is a major unmet need in oncology. The remaining uncertainty on its originating tissue has hampered the discovery of molecular oncogenic pathways and the development of effective therapies.
20p vibransone 28-03-2024 7 2 Download
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Molecular characterization has the potential to advance the management of pediatric cancer and high-risk hematologic disease. The clinical integration of genome sequencing into standard clinical practice has been limited and the potential utility of genome sequencing to identify clinically impactful information beyond targetable alterations has been underestimated.
19p vioraclene 31-03-2024 4 2 Download
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While understanding molecular heterogeneity across patients underpins precision oncology, there is increasing appreciation for taking intra-tumor heterogeneity into account. Based on large-scale analysis of cancer omics datasets, we highlight the importance of intra-tumor transcriptomic heterogeneity (ITTH) for predicting clinical outcomes.
14p vibransone 28-03-2024 4 2 Download
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Recent rapid biotechnological breakthroughs have led to the identification of complex and unique molecular features that drive malignancies. Precision medicine has exploited next-generation sequencing and matched targeted therapy/immunotherapy deployment to successfully transform the outlook for several fatal cancers.
27p viellison 28-03-2024 6 2 Download
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Ebook "Molecular biology of human cancers: An advanced student’s textbook" is to provide advanced students and practitioners of different disciplines with this basis, bridging the gap between standard textbooks of molecular biology, pathology, and oncology on the one hand and the specialized cancer literature on the other.
519p cotieubac1004 15-03-2024 1 0 Download
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Children with relapsed central nervous system (CNS tumors), neuroblastoma, sarcomas, and other rare solid tumors face poor outcomes. This prospective clinical trial examined the feasibility of combining genomic and transcriptomic profiling of tumor samples with a molecular tumor board (MTB) approach to make real‑time treatment decisions for children with relapsed/refractory solid tumors.
18p vicwell 29-02-2024 5 1 Download
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Ebook "Applications of biotechnology in oncology" collects key writings by Kewal K. Jain on the most important contributions of biotechnology to cancer research, particularly to the molecular diagnosis of cancer and drug delivery in cancer for personalized management of patients. Basics of various “omics” technologies and their application in oncology are described as oncogenomics and oncoproteomics.
885p nhanphanguyet 28-01-2024 3 2 Download
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Part 1 book "Withrow and MacEwen's small animal clinical oncology" includes content: The etiology of cancer; tumor biology and metastasis; the pathology of neoplasia; epidemiology and the evidence based medicine approach; paraneoplastic syndromes; diagnostic imaging in oncology; diagnostic cytopathology in clinical oncology; molecular diagnostics; biopsy and sentinel lymph node mapping principles;... and other contents.
387p muasambanhan05 22-01-2024 4 2 Download
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Part 1 book "Tumors in domestic animals" includes content: An overview of molecular cancer pathogenesis, prognosis, and diagnosis; trimming tumors for diagnosis and prognosis; immunohistochemistry - fundamentals and applications in oncology; epithelial and melanocytic tumors of the skin; mesenchymal tumors of the skin and soft tissues, mast cell tumors, tumors of the hemolymphatic system, canine and feline histiocytic diseases,... and other contents.
474p muasambanhan05 22-01-2024 3 2 Download
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Precision oncology, defined as treatment of patients with targeted therapies matched to specific molecular alterations, has entered routine clinical practice. Particularly in patients with advanced cancer or hemato‑ logic malignancies, for whom no further standard therapies are available, this approach is increasingly applied as last resort option outside of the approved indication.
7p visharma 20-10-2023 4 2 Download
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Rat sarcoma viral oncogene homolog (RAS) gene mutation is a common molecular event in colorectal cancer (CRC). This study may provide new ideas for optimizing oncology treatment planning for RAS mutant, MSS mCRC patients in the first-line set.
9p vioracle 29-09-2023 3 2 Download
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Part 1 of ebook "An atlas of gynecologic oncology: Investigation and surgery (Fourth edition)" provide readers with content about: introduction - preparing a patient for surgery; preoperative workup; cross-sectional and molecular imaging; sigmoidoscopy, cystoscopy, and stenting; tumor markers; radical abdominal hysterectomy;... Please refer to the ebook for details!
222p tieuduongchi 24-10-2022 4 2 Download
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The molecular-based classification of canine mammary carcinomas (CMCs) has been the focus of much current research. Both in canines and humans, the triple-negative (TN) molecular subtype of mammary cancer is defined by a lack of expression of progesterone receptor (PR), oestrogen receptor (ER) and HER2.
14p vidarwin 23-02-2022 11 1 Download
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Despite lower cancer incidence rates, cancer mortality is higher among rural compared to urban dwellers. Patient, provider, and institutional level factors contribute to these disparities. The overarching objective of this study is to leverage the multidisciplinary, multispecialty oncology team from an academic cancer center in order to provide comprehensive cancer care at both the patient and provider levels in rural healthcare centers.
11p vimahuateng 26-11-2021 9 1 Download
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This paper provides an overview of systematic reviews that assessed the effectiveness of SOT compared with the best supportive care (BSC) or placebo in patients with advanced esophageal or gastric cancers in an end-of-life context.
18p vimahuateng 26-11-2021 7 1 Download
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Transmissible cancers lie at the intersection of oncology and infectious disease, two traditionally divergent fields for which gene expression studies are particularly useful for identifying the molecular basis of phenotypic variation. In oncology, transcriptomics studies, which characterize the expression of thousands of genes, have identified processes leading to heterogeneity in cancer phenotypes and individual prognoses.
19p vitzuyu2711 29-09-2021 6 1 Download
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Giant cell tumor of the bone (GCTB) is classified as an intermediate, locally aggressive but rarely metastasizing tumor. The mainstay of treatment for the treatment of GCTB had been the surgical removal until an anti- receptor activator of nuclear factor-kappa B ligands (RANKL) antibody denosumab was developed.
7p vioregon2711 22-02-2021 8 1 Download