Molecular pathway

We recently found that epiplakin 1 (EPPK1) alterations were present in 12% of lung adenocarcinoma (LUAD) cases and were associated with a poor prognosis in early-stage LUAD when combined with other molecular alterations. This study aimed to identify a probable crucial role for EPPK1 in cancer development.

13p vishanshan 27-06-2024 1 1   Download

Considering the age relevance of prostate cancer (PCa) and the involvement of the cGAS-STING pathway in aging and cancer, we aim to classify PCa into distinct molecular subtypes and identify key genes from the novel perspective of the cGAS-STING pathway. It is of significance to guide personalized intervention of cancer-targeting therapy based on genetic evidence.

11p vikoch 27-06-2024 3 1   Download

Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide. Inhibitor of kappa B kinase interacting protein (IKBIP) has been reported to promote glioma progression, but its role in other cancers remains unclear. This study aimed to investigate the role of IKBIP and its underlying molecular mechanisms in ESCC.

16p vikoch 27-06-2024 1 1   Download

Ovarian cancer is one of the most common gynecological malignancies due to the lack of early symptoms, early diagnosis and limited screening. Therefore, it is necessary to understand the molecular mechanism underlying the occurrence and progression of ovarian cancer and to identify a basic biomarker for the early diagnosis and clinical treatment of ovarian cancer.

13p vikoch 27-06-2024 1 1   Download

The primary aim of Cerebral Signal Transduction: From First to Fourth Messengers, therefore, is to offer a comprehensive picture of the recent advances made in the signaling field as it relates to neuronal and cere­ bral function. The current state of progress provides an exciting opportunity for such a comprehensive focus because molecular tools have become available to selectively remove, reduce, or enhance spe­ cific components in the signaling pathways, e. g. , by interfering with the genes encoding key proteins.

441p vimeyers 29-05-2024 3 2   Download

Ebook "Mitochondria and cancer" presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins.

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Ebook "Cellular and molecular control of neuronal migration" provides an up-to-date collection of reviews on the molecular and cellular principles of neuronal migration in the mammalian brain. Over the last decades a rich catalogue of signaling molecules controlling neuronal migration has been compiled, and within this book an international panel of experts provides up-to-date discussions of the state of knowledge how these distinct signaling pathways regulate various aspects of neuronal migration.

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In ebook "Developmental biology of neoplastic growth" tumour growth is perceived as a deviation from the normal development of the human organism. The molecular, cellular, and tissue determinants of different tumours are discussed showing that each is a different disease, often corresponding to a particular developmental stage. The natural history of several cancers illustrates how clinical incidence can be just the visible part of the iceberg, while the first changes at the tissue level sometimes occur several years before tumour growth becomes manifest.

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Ebook "Cell death signaling in cancer biology and treatment" is to describe state-of-the-art approaches and future opportunities for achieving this goal by targeting mechanisms and pathways that regulate cancer cell death. In this book, molecular defects in cell death signaling that characterize cancer cells, including dysregulation of cell death due to overexpression/hyperactivation of oncoproteins, as well as the loss of tumor suppressor proteins will be described.

412p tracanhphuonghoa1007 22-04-2024 3 1   Download

Ebook "An integrated approach for added-value products from lignocellulosic biorefineries: Vanillin, syringaldehyde, polyphenols and polyurethane" offers the state of the art on the progress and accomplishments of 25 years of research at the Associate Laboratory LSRE-LCM - Laboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials on lignin conversion to value-added products and their downstream separation.

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Glycosylphosphatidylinositol biosynthesis defects (GPIBDs) cause a group of phenotypically overlapping recessive syndromes with intellectual disability, for which pathogenic mutations have been described in 16 genes of the corresponding molecular pathway.

13p vibransone 28-03-2024 6 2   Download

High-grade serous ovarian cancer (HGSOC) is a major unmet need in oncology. The remaining uncertainty on its originating tissue has hampered the discovery of molecular oncogenic pathways and the development of effective therapies.

20p vibransone 28-03-2024 7 2   Download

Ebook "Food allergens: Biochemistry and molecular nutrition" covers the topics of biochemistry, digestibility, and uptake in the gastrointestinal tract of the most important food allergens causing IgE-mediated food allergy that is believed to be responsible for most immediate-type, foodinduced hypersensitive reactions.

217p tudohanhtau1006 29-03-2024 4 2   Download

Pathway enrichment analysis (PEA) is a common method for exploring functions of hundreds of genes and identifying disease-risk pathways. Moreover, diferent pathways exert their functions through crosstalk.

20p viellison 28-03-2024 2 1   Download

Ebook "A systems biology approach to blood" is divided into three main sections: basic components, physiological processes, and clinical applications. Using blood as a window, one can study health and disease through this unique tool box with reactive biological fluids that mirrors the prevailing hemodynamics of the vessel walls and the various blood cell types. Many blood diseases, rare and common can and have been exploited using systems biology approaches with successful results and therefore ideal models for systems medicine.

402p cotieubac1004 15-03-2024 0 0   Download

Ebook "Computational modeling of biological systems: From molecules to pathways" provides an overview of the established computational methods used for modeling biologically and medically relevant systems. Computational modeling is emerging as a powerful new approach to study and manipulate biological systems. Multiple methods have been developed to model, visualize, and rationally alter systems at various length scales, starting from molecular modeling and design at atomic resolution to cellular pathways modeling and analysis.

360p duongthandue0501 28-02-2024 6 1   Download

The prognosis for patients with head and neck cancer (HNC) is poor and has improved little in recent decades, partially due to lack of therapeutic options. To identify effective therapeutic targets, we sought to identify molecular pathways that drive metastasis and HNC progression, through large-scale systematic analyses of transcriptomic data.

26p vicwell 29-02-2024 4 2   Download

Irritable bowel syndrome (IBS) often co-occurs with psychiatric and gastrointestinal disorders. A recent genome-wide association study (GWAS) identified several genetic risk variants for IBS. However, most of the heritability remains unidentified, and the genetic overlap with psychiatric and somatic disorders is not quantified beyond genome-wide genetic correlations.

18p vicwell 29-02-2024 4 1   Download

Ebook "Programmed cell death in cancer progression and therapy (Advances in experimental medicine and biology, Volume 615)" give a comprehensive overview of the mechanisms that are involved in mediating and regulating PCD in cancer. We also provide a detailed indication of the utility of PCD in cancer therapy. This book will be a valuable resource for researchers investigating the role of PCD in cancer and other diseases, researchers investigating the molecular mechanism of chemotherapeutic agents and drug-resistance in cancer and for physicians using chemotherapeutic agents.

362p duongthandue0501 28-02-2024 1 1   Download

Ebook "Progress and opportunities of doubled haploid production" deals with the historical perspectives and the current status of doubled haploid production along with its practical implications in basic and applied research. It highlights various haploid production methods with a comprehensive discussion on their pros and cons, bottlenecks, and embryogenic pathways.

84p manmanthanhla0201 26-02-2024 4 1   Download