Molecular underpinnings

Tumor hypoxia is associated with prostate cancer (PCa) treatment resistance and poor prognosis. Pimonidazole (PIMO) is an investigational hypoxia probe used in clinical trials. A better understanding of the clinical significance and molecular alterations underpinning PIMO-labeled tumor hypoxia is needed for future clinical application.

12p vikoch 27-06-2024 1 1   Download

While understanding molecular heterogeneity across patients underpins precision oncology, there is increasing appreciation for taking intra-tumor heterogeneity into account. Based on large-scale analysis of cancer omics datasets, we highlight the importance of intra-tumor transcriptomic heterogeneity (ITTH) for predicting clinical outcomes.

14p vibransone 28-03-2024 4 2   Download

Ebook "Astrochemistry and astrobiology (Physical chemistry in action series)" is the debut volume in the new series Physical Chemistry in Action. Aimed at both the novice and experienced researcher, this volume outlines the physico-chemical principles which underpin our attempts to understand astrochemistry and predict astrobiology. An introductory chapter includes fundamental aspects of physical chemistry required for understanding the field. Eight further chapters address specific topics, encompassing basic theory and models, up-to-date research and an outlook on future work.

353p coduathanh1122 27-03-2024 3 1   Download

Ebook "Biopolymers: A molecular paleontology approach" provides an overview, research compendium and an introduction to the science of molecular paleontology, including literature overview for non-geochemists. Analytical methods employed are included as a part of each chapter that underpin this branch of paleontology and indeed geochemistry. The primary usefulness of this volume is for organic geochemists, molecular palaeontologists, and molecular archeologists.

196p duongthandue0501 28-02-2024 3 1   Download

Ebook "Frontiers in quantum systems in chemistry and physics" wwill feature the very latest developments in the study of matter at the molecular level as applied to biochemistry, nanotechnology, molecular electronics, astrochemistry, quantum pharmacology, light harvesting, and battery design; will show how a study at the molecular level underpins much of modern science from the development of smart responsive structural materials to the design of synthetic bio-materials;...

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Classical molecular dynamics simulations have been employed to study the exchange of Na+ for Hg2+ in zeolite Na-A, with a Si/Al ratio of 1, and zeolite Na-Y, with Si/Al ratios of 2 and 5, in dry and hydrated conditions within the temperature range 330 – 360 K, to understand factors underpinning the performance of zeolites for water decontamination.

9p vironald 15-12-2022 11 2   Download

A major bottleneck in our understanding of the molecular underpinnings of life is the assignment of function to proteins. While molecular experiments provide the most reliable annotation of proteins, their relatively low throughput and restricted purview have led to an increasing role for computational function prediction.

19p viaristotle 29-01-2022 11 0   Download

Genome wide association studies (GWAS) have helped identify large numbers of genetic loci that significantly associate with increased risk of developing diseases. However, translating genetic knowledge into understanding of the molecular mechanisms underpinning disease (i.e. disease-specific impacted biological processes) has to date proved to be a major challenge. This is primarily due to difficulties in confidently defining candidate genes at GWAS-risk loci.

8p vibeauty 23-10-2021 5 0   Download

Feed efficiency (FE) is an indicator of efficiency in converting energy and nutrients from feed into a tissue that is of major environmental and economic significance. The molecular mechanisms contributing to differences in FE are not fully elucidated, therefore the objective of this study was to profile the porcine Longissimus thoracis et lumborum (LTL) muscle transcriptome, examine the product quality from pigs divergent in FE and investigate the functional networks underpinning the potential relationship between product quality and FE.

18p vitzuyu2711 29-09-2021 15 1   Download

Chemosensory proteins are a family of insect-specific chemical sensors that sense specific chemical cues and regulate insect behavior. Chemosensory proteins have been identified and analyzed in many insect species, such as Drosophila melanogaster, Bactrocera dorsalis and Calliphora stygia.

12p viseulgi2711 31-08-2021 9 1   Download

Ketosis is a common metabolic disease during the transition period in dairy cattle, resulting in longterm economic loss to the dairy industry worldwide. While genetic selection of resistance to ketosis has been adopted by many countries, the genetic and biological basis underlying ketosis is poorly understood.

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While leeches in the genus Hirudo have long been models for neurobiology, the molecular underpinnings of nervous system structure and function in this group remain largely unknown.

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(BQ) The Editors are delighted to welcome you to the 65th anniversary thirteenth edition of Williams Textbook of Endocrinology. In this new edition we have strived to maintain Robert Williams’ original 1950 mandate to publish “a condensed and authoritative discussion of the management of clinical endocrinopathies based upon the application of fundamental information obtained from chemical and physiological investigation.

314p nanhankhuoctai7 01-07-2020 14 2   Download

Alkaline/neutral invertase (A/N-INV), an enzyme that hydrolyzes sucrose irreversibly into glucose and fructose, is essential for normal plant growth,development, and stress tolerance. However, the physiological and/or molecular mechanism underpinning the role of A/N-INV in abiotic stress tolerance is poorly understood.

18p vihashirama2711 21-05-2020 17 0   Download

Carcinogenesis covers molecular, biochemical and cellular processes that underpin this field. The complex nature of cancer means that a broad understanding of these processes is advantageous when designing novel preventative, therapeutic or diagnostic strategies. This book commences with chapters discussing cancer predisposition and pre-cancerous lesions. Factors that initiate or progress cancer development, including viral, hormonal, oncogenic and biochemical stimuli are then described, as are interactions with the cancer extracellular environment....

328p phoebe75 19-02-2013 44 5   Download

We planned the first edition of this book on a ‘need to know’ basis, its primary object being to provide students and medical and dental practitioners with the knowledge essential for an informed approach to the prevention and treatment of viral infections. We aimed also at supplying just enough basic virology to underpin the more practical aspects—clinical manifestations, epidemiology, pathogenesis, immune responses, and so forth. And not least, we tried our best to make the text as readable as is possible, given the highly technical nature of some of the material.

142p mnemosyne75 02-02-2013 75 9   Download

Despite its clinical importance, a dearth of information exists on the cellular and molecular mechanisms that underpin brain stem death. A suitable neural substrate for mechanistic delineation on brain stem death resides in the rostral ventrolateral medulla (RVLM) because it is the origin of a life-and-death signal that sequentially increases (pro-life) and decreases (pro-death) to reflect the advancing central cardiovascular regulatory dysfunction during the progression towards brain stem death in critically ill patients.

12p toshiba23 18-11-2011 51 1   Download