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Mosaic mutation
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The contribution of somatic mosaicism, or genetic mutations arising after oocyte fertilization, to congenital heart disease (CHD) is not well understood. Further, the relationship between mosaicism in blood and cardiovascular tissue has not been determined.
18p
vibransone
28-03-2024
5
2
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Mosaic mutations acquired during early embryogenesis can lead to severe early-onset genetic disorders and cancer predisposition, but are often undetectable in blood samples. The rate and mutational spectrum of embryonic mosaic mutations (EMMs) have only been studied in few tissues, and their contribution to genetic disorders is unknown.
14p
vibransone
28-03-2024
2
2
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Antimicrobial resistance in Neisseria gonorrhoeae is a global health concern. Strains from two internationally circulating sequence types, ST-7363 and ST-1901, have acquired resistance to third-generation cephalosporins, mainly due to mosaic penA alleles.
12p
vibransone
28-03-2024
4
2
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Focal dermal hypoplasia (Goltz syndrome), is an exceedingly rare X-linked dominant genetic disorder. It is a multisystem disease, but it is hallmarked by characteristic skin changes. Focal dermal hypoplasia typically occurs in females (90%), and males are thought to only survive through having either a sporadic new mutation or somatic mosaicism.
4p
viintuit
26-09-2023
6
0
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Surveillance for bovine genetic diseases in Denmark identified a hitherto unreported congenital syndrome occurring among progeny of a Holstein sire used for artificial breeding. A genetic aetiology due to a dominant inheritance with incomplete penetrance or a mosaic germline mutation was suspected as all recorded cases were progeny of the same sire.
9p
vinarcissa
21-03-2023
2
1
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Post-zygotic mutations incurred during DNA replication, DNA repair, and other cellular processes lead to somatic mosaicism. Somatic mosaicism is an established cause of various diseases, including cancers.
32p
viarchimedes
26-01-2022
5
0
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Abelmoschus esculentus (L.) Moench, commonly known as ‘ladies finger’ or ‘bhindi’ is an economically important common vegetable crop cultivated throughout the tropical and warm temperate regions of the world. Induced mutation is highly effective in enhancing natural genetic resources and has been used in developing improved cultivars. The effect of gamma irradiation on various morphological and yield attributing characters in M2 generation were studied.
6p
cothumenhmong9
04-01-2021
11
2
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The study of mosaic mutation is important since it has been linked to cancer and various disorders. Single cell sequencing has become a powerful tool to study the genome of individual cells for the detection of mosaic mutations.
10p
vikentucky2711
24-11-2020
9
1
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French bean is one of the most important legume vegetables with highly antidiabetic property and used for cardiac problems. Mungbean yellow mosaic virus (MYMV) is one of the destructive viral diseases affecting yield potential of french bean both quantitatively and qualitatively. Induced mutations have offered a single and short alternative to conventional breeding including isolation, screening, selection and testing generation after generation. An investigation was carried out with Arka Anoop (French bean cultivar), treated with mutagen Ethyl Methane Sulphonate (EMS) at the dose of 0.
6p
caygaocaolon3
09-03-2020
18
1
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Papaya mosaic potexvirus (PapMV) coat protein (CP) was expressed (CPDN5) inEscherichia coliand showed to self assemble into nucleocapsid like particles (NLPs). Twenty per cent of the purified protein was found as NLPs of 50 nm in length and 80% was found as a multimer of 450 kDa (20 subunits) arranged in a disk.
12p
dell39
27-03-2013
38
2
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Transmission of Genetic Disease Origins and Types of Mutations A mutation can be defined as any change in the primary nucleotide sequence of DNA regardless of its functional consequences. Some mutations may be lethal, others are less deleterious, and some may confer an evolutionary advantage. Mutations can occur in the germline (sperm or oocytes); these can be transmitted to progeny. Alternatively, mutations can occur during embryogenesis or in somatic tissues.
5p
konheokonmummim
03-12-2010
69
3
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