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Muscle cell death
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Immune checkpoint blockade (ICB) with antibodies inhibiting cytotoxic T lymphocyte-associated protein-4 (CTLA-4) and programmed cell death protein-1 (PD-1) (or its ligand (PD-L1)) can stimulate immune responses against cancer and have revolutionized the treatment of tumors.
13p
vibransone
28-03-2024
8
2
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Women account for 60% of all stroke deaths and are more often permanently disabled than men, despite their higher observed stroke incidence. Considering the clinical population affected by stroke, an obvious drawback is that many pre-clinical and clinical studies only investigate young males.
19p
vilichoo2711
25-06-2021
18
1
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The contribution of programmed cell death (PCD) to muscle wasting disorders remains a matter of debate. Drosophila melanogaster metamorphosis offers the opportunity to study muscle cell death in the context of development. Using live cell imaging of the abdomen, two groups of larval muscles can be observed, doomed muscles that undergo histolysis and persistent muscles that are remodelled and survive into adulthood.
18p
viwyoming2711
16-12-2020
11
0
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Many human muscle wasting diseases are associated with abnormal nuclear localization. During metamorphosis in Drosophila melanogaster, multi-nucleated larval dorsal abdominal muscles either undergo cell death or are remodeled to temporary adult muscles.
17p
viflorida2711
30-10-2020
13
2
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While programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) checkpoint inhibitors have activity in a proportion of patients with advanced bladder cancer, strongly predictive and prognostic biomarkers are still lacking.
11p
vimale2711
25-08-2020
10
1
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Cancer cachexia is a cancer-induced metabolic disorder and a major cause of cancer-induced death. The constituents of cancer cachexia include an increase in energy expenditure, hepatic gluconeogenesis, fat lipolysis, and skeletal-muscle proteolysis and a decrease in body weight.
12p
vibaku2711
22-07-2020
14
2
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The R-Spondin proteins comprise a family of secreted proteins, known for their important roles in cell proliferation, differentiation and death, by inducing the Wnt pathway. Several studies have demonstrated the importance of RSPOs in regulation of a number of tissue-specific processes, namely: bone formation, skeletal muscle tissue development, proliferation of pancreatic β-cells and intestinal stem cells and even cancer.
14p
vihamax2711
21-04-2020
17
1
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We investigated the role of programmed necrosis (necroptosis), a newly recognized form of cell necrosis that has been implicated in the development of steroid-induced osteonecrosis. We used an osteonecrosis model in which 30 Japanese white rabbits each weighing 3.5kg were injected once with methylprednisolone at 20 mg/kg body weight into the right gluteal muscle.
5p
vilusaka2711
19-11-2019
11
0
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Sepsis, a leading cause of death in intensive care units, is generally associated with vascular dysfunction. However, its pathophysiological process has not been fully clarified, lacking in-depth knowledge of its pathophysiological process may hinder the improvement of diagnosis and therapy for sepsis.
8p
vinasaki2711
12-11-2019
13
1
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This paper concerns primarily the elderly who live in congregate care settings, including independent living, assisted living, long term care, or continuing care retirement communities (CCRF). Concern for quality of life of older residents must today, more than ever before, include intensive planning and preparation for emergencies and disasters that would compromise the safety of our most at-risk elderly.
8p
thankinhphanliet
01-01-2013
47
5
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The inflammatory process both reduces collagen synthesis by inhibiting the smooth muscle cell and causes its death by apoptosis. Macrophages also produce a wide range of metalloproteinases capable of degrading all the components of the connective tissue matrix, including collagen. These metalloproteinases are secreted into the tissues in an inactive form and then activated by plasmin. Metalloproteinase production by macrophages is upregulated by inflammatory cytokines such as TNFá.
259p
ozon_ozon
02-05-2012
52
7
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Ting and Dehdary International Journal of Emergency Medicine 2011, 4:20 http://www.intjem.com/content/4/1/20 CASE REPORT Open Access Acute severe non-traumatic muscle injury following reperfusion surgery for acute aortic occlusion: case report Joseph Y Ting* and Arash Dehdary Abstract Acute aortic occlusion is a rare but catastrophic disease with a high mortality rate. Severe perioperative complications could result from revascularization of infarcted muscles.
4p
dauphong13
09-02-2012
47
4
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CHỦ ĐỀ BẠN MUỐN TÌM
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