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Myelodysplastic syndromes
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Myelodysplastic syndrome (MDS) is known to arise through the pathogenic bone marrow mesenchymal stem cells (MSC) by interacting with hematopoietic stem cells (HSC). However, due to the strong heterogeneity of MDS patients, it is difficult to find common targets in studies with limited sample sizes. This study aimed to describe sequential molecular changes and identify biomarkers in MSC of MDS transformation.
14p
vikoch
27-06-2024
1
1
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Myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML) are characterised by abnormal epigenetic repression and differentiation of bone marrow haematopoietic stem cells (HSCs). Drugs that reverse epigenetic repression, such as 5-azacytidine (5-AZA), induce haematological improvement in half of treated patients.
18p
vibransone
28-03-2024
3
2
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Myelodysplastic syndromes (MDS) are clonal hematopoietic diseases of the elderly characterized by chronic cytopenias, ineffective and dysplastic haematopoiesis, recurrent genetic abnormalities and increased risk of progression to acute myeloid leukemia.
10p
vialfrednobel
23-12-2023
4
3
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Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) comprise several rare hematologic malignancies with shared concomitant dysplastic and proliferative clinicopathologic features of bone marrow failure and propensity of acute leukemic transformation, and have significant impact on patient quality of life.
15p
vialfrednobel
23-12-2023
6
4
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Myelodysplastic Neoplasms (MDS) are clonal stem cell disorders characterized by ineffective hematopoiesis and progression to acute myeloid leukemia, myelodysplasia-related (AML-MR). A major mechanism of pathogenesis of MDS is the aberration of the epigenetic landscape of the hematopoietic stem cells and/or progenitor cells, especially DNA cytosine methylation, and demethylation.
18p
vialfrednobel
23-12-2023
4
3
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Part 2 book "Veterinary comparative hematopathology" includes content: T-Cell and NK-Cell neoplasms, acute myeloid leukemias, chronic myeloproliferative diseases, myeloproliferative/Myelodysplastic diseases, myelodysplastic syndromes, hodgkin’s lymphoma, histiocytoses.
284p
oursky07
24-10-2023
7
4
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Currently, there is no standard treatment for managing relapse in patients with acute myeloid leukemia and myelodysplastic syndrome (AML/MDS) after allogeneic hematopoietic cell transplantation. The aim of this systematic review and meta-analysis was to evaluate the efficacy and adverse events of Venetoclax combined with hypomethylating agents (HMAs) for AML/MDS relapse post-transplantation.
12p
vioracle
29-09-2023
5
2
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Part 1 book "The genetic basis of haematological cancers" includes content: Molecular genetics of paediatric acute myeloid leukaemia, acute lymphoblastic leukaemia, the genetics of mature B-cell malignancies, the genetics of chronic myelogenous leukaemia.
180p
oursky01
24-07-2023
8
3
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Part 1 book "The genetic basis of haematological cancers" includes content: The myelodysplastic syndromes, molecular genetics of the myeloproliferative neoplasms, acute myeloid leukaemia.
218p
oursky01
24-07-2023
2
2
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Environmental exposure to benzene and toluene is a suspected risk factor for metabolic disorders among the general adult population. However, the effects of benzene and toluene on blood lipid profiles remain unclear.
9p
viferrari
29-10-2022
4
2
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Increasing germline gene mutations have been discovered in haematological malignancies with the development of next-generation sequencing (NGS), which is critical for proper clinical management and long-term follow-up of affected individuals.
15p
vikolindagrabar
27-07-2022
9
2
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Myelodysplastic syndromes (MDS) is a group of heterogeneous myeloid clonal diseases originating from hematopoietic stem cells. It has been demonstrated that apolipoproteins A1(ApoA1) are associated with disease risk in many cancer types. However, there still lacks evidence regarding the link between ApoA1 and MDS.
9p
vipriyankagandhi
27-07-2022
4
1
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This report summarizes three phase I studies evaluating volasertib, a polo-like kinase inhibitor, plus azacitidine in adults with myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia, or acute myeloid leukemia.
9p
visusanwojcicki
28-06-2022
12
2
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The mixed-lineage leukemia (MLL) gene is located on chromosome 11q23. The MLL gene can be rear‑ ranged to generate partial tandem duplications (MLL-PTD), which occurs in about 5-10% of acute myeloid leukemia (AML) with a normal karyotype and in 5-6% of myelodysplastic syndrome (MDS) patients. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is currently one of the curative therapies available for AML and MDS with excess blasts (MDS-EB).
11p
vielonmusk
21-01-2022
9
0
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Feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) are typical retroviruses that are transmitted horizontally among felines. FIV results in symptoms of immunodeficiency such as weight loss, chronic lesions, opportunistic infections, and neurological abnormalities, while FeLV is known to cause a variety of neoplastic and nonneoplastic diseases in cats, such as thymic lymphoma, multicentric lymphoma myelodysplastic syndromes, acute myeloid leukemia, aplastic anemia, and immunodeficiency.
7p
dolomite36
30-12-2021
3
1
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The treatment strategies for Myelodysplastic Syndromes (MDS) are usually based on the risk stratification system. However, few risk signatures which integrate the revised international prognostic scoring system (IPSS-R) with gene mutations can be easily applied in the real world.
9p
vianrose2711
27-04-2021
7
1
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Although myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN) – including chronic myeloid leukemia (CML) – and myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are largely clinically distinct myeloid malignancies, epidemiological studies rarely examine them separately and often combine them with lymphoid malignancies, limiting possible etiological interpretations for specific myeloid malignancies.
22p
vianrose2711
27-04-2021
11
1
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Secondary pulmonary alveolar proteinosis (sPAP) is a very rare lung disorder comprising approximately 10% of cases of acquired PAP. Hematological disorders are the most common underlying conditions of sPAP, of which 74% of cases demonstrate myelodysplastic syndrome (MDS). However, the impact of sPAP on the prognosis of underlying MDS remains unknown.
10p
vimontana2711
05-04-2021
9
2
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Factors affecting the safety of bronchoscopy in patients with malignant hematologic disorders have not been well described. We evaluated the safety of bronchoscopy and describe factors affecting its complication rate in such patients.
6p
vimichigan2711
26-03-2021
11
2
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Secondary pulmonary alveolar proteinosis (sPAP) is an extremely rare disease. The clinical features of sPAP patients remain to be summarizeds. MDS and TB infection were the most frequent underlying causes of sPAP in this single-center research in China, with cases secondary to MDS having a poor survival rate.
7p
vimaine2711
26-03-2021
8
3
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