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Neutrophil elastase
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As circulating DNA (cirDNA) is mainly detected as mononucleosome-associated circulating DNA (mono-N cirDNA) in blood, apoptosis has until now been considered as the main source of cirDNA.
24p
vicwell
29-02-2024
1
1
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Severe congenital neutropenia (SCN) is an exceptionally rare genetic disorder associated with life-threatening bacterial infections. Among the several genetic variations related to SCN, heterozygous mutations in the ELANE gene encoding neutrophil elastase account for approximately 40 - 55% of the genetic causes.
6p
vischultz
17-10-2023
4
2
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Severe congenital neutropenia (SCN) is a congenital condition in which granulocytes mature abnormally owing to a variety of genetic defects, resulting in immunodeficiency. Among the several genetic variations related to SCN, heterozygous mutations in the ELANE gene encoding neutrophil elastase account for approximately 60% of the genetic causes.
9p
vicaptainmarvel
21-04-2023
4
2
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Alpha-1 antitrypsin (A1AT) is one of the acute phase proteins which are synthesized in the liver. A1AT inhibits the activity of many proteases, but its main task is to protect the lungs from the attack of neutrophil elastase. In an autosomal hereditary disease known as alpha-1 antitrypsin deficiency, the A1AT level in blood serum decreases, increasing the risk of developing emphysema, liver apoptosis, and liver cancer. Thus, the detection of A1AT concentration in blood serum is very important.
15p
tudichquannguyet
29-11-2021
6
1
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During the pathological destruction of lung tissue, neutrophil elastase (NE) degrades elastin, one of the major constituents of lung parenchyma. However there are no non-invasive methods to quantify NE degradation of elastin. We selected specific elastin fragments generated by NE for antibody generation and developed an ELISA assay (EL-NE) for the quantification of NE-degraded elastin.
7p
vimontana2711
05-04-2021
11
3
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Inheritance of the F variant of alpha-1-antitrypsin is associated with normal circulating protein levels, but it is believed to be dysfunctional in its ability to inhibit neutrophil elastase and therefore has been implicated as a susceptibility factor for the development of emphysema.
7p
vimontana2711
05-04-2021
9
1
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Human neutrophil elastase (HNE) is a potent serine protease belonging to the chymotrypsin family and is involved in a variety of pathologies affecting the respiratory system. Thus, compounds able to inhibit HNE proteolytic activity could represent effective therapeutics.
15p
vijiraiya2711
27-05-2020
12
1
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Nuclear localization signal retinoic acid receptor alpha(NLS-RARα), which forms from the cleavage of promyelocytic leukemia-retinoic acid receptor alpha(PML-RAR α ) protein by neutrophil elastase(NE), possesses an important role in the occurrence and development of acute promyelocytic leukemia(APL).
9p
viwashington2711
04-12-2019
9
0
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Elafin and its precursor, trappin-2 or pre-elafin, are specific endogenous inhibitors of human neutrophil elastase and proteinase 3 but not of cathepsin G. Both inhibitors belong, together with secretory leukocyte protease inhibitor, to the chelonianin family of canonical protease inhibitors of serine proteases. AcDNAcoding either elafin or its precursor, trappin-2, was fused in framewith yeasta-factor cDNAand expressedinthePichiapastorisyeast expressionsystem.
9p
dell39
03-04-2013
38
3
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Neutrophil proteinase-mediated lung tissue destruction is prevented by inhibitors, including elafin and its precursor, trappin. We wanted to estab-lish whether neutrophil-derived oxidants might impair the inhibitory func-tion of these molecules. Myeloperoxidase⁄H2O2 and N-chlorosuccinimide oxidation of the inhibitors was checked by mass spectrometry and enzy-matic methods.
11p
dell39
27-03-2013
42
3
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Proteinase 3 and neutrophil elastase are serine proteinases of the polymor-phonuclear neutrophils, which are considered to have both similar localiza-tion and ligand specificity because of their high sequence similarity. However, recent studies indicate that they might have different and yet complementary physiologic roles.
17p
mobifone23
21-01-2013
37
3
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Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Neutrophil elastase, an acid-independent serine protease, facilitates reovirus uncoating and infection in U937 promonocyte cells
14p
dauphong8
14-01-2012
37
2
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Neutrophil elastase, an acid-independent serine protease, facilitates reovirus uncoating and infection in U937 promonocyte cells
14p
dauphong6
05-01-2012
36
5
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Neutrophil elastase downmodulates native GCSFR expression and granulocyte-macrophage colony formation...
10p
thulanh27
13-12-2011
34
2
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Is neutrophil elastase the missing link between emphysema and fibrosis? Evidence from two mouse models...
14p
toshiba14
22-10-2011
53
3
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Collaborative interactions between neutrophil elastase and metalloproteinases in extracellular matrix degradation in threedimensional collagen gels...
7p
toshiba13
22-10-2011
50
3
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Open Access SP-A binds alpha1-antitrypsin in vitro and reduces the association rate constant for neutrophil elastase...
12p
toshiba13
22-10-2011
45
3
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Neutrophil elastase reduces secretion of secretory leukoproteinase inhibitor (SLPI) by lung epithelial cells: role of charge of the proteinase-inhibitor complex...
15p
toshiba12
21-10-2011
42
3
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Effect of neutrophil elastase and its inhibitor EPI-hNE4 on transepithelial sodium transport across normal and cystic fibrosis human nasal epithelial cells...
9p
toshiba11
19-10-2011
38
3
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