Novel therapeutic
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With the increasing of novel therapeutics for the treatment of Biliary Tract Cancers (BTC), and the need to assess their socio-economic impacts for national licence approvals, it is as important as ever to have real-life data in national populations.
10p vishanshan 27-06-2024 1 1 Download
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Modulation of DNA damage repair in lung squamous cell carcinoma (LUSC) can result in the generation of neoantigens and heightened immunogenicity. Therefore, understanding DNA damage repair mechanisms holds significant clinical relevance for identifying targets for immunotherapy and devising therapeutic strategies.
15p vishanshan 27-06-2024 1 1 Download
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Autologous stem-cell transplantation (ASCT) remains a beneficial approach for patients with newly diagnosed multiple myeloma (NDMM) in the age of novel therapeutic agents. Nevertheless, limited real-world data is available to establish criteria for identifying high-risk ASCT patients.
11p vishanshan 27-06-2024 1 1 Download
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Biliary tract cancer (BTC) is a relatively rare but aggressive gastrointestinal cancer with a high mortality rate. Cancer stem cell (CSC) populations play crucial roles in tumor biology and are responsible for the low response to anti-cancer treatment and the high recurrence rate. This study investigated the role of Transgelin-2 (TAGLN2), overexpressed in CSC in BTC cells, and analyzed its expression in patient tissues and serum to identify potential new targets for BTC.
15p vishanshan 27-06-2024 1 1 Download
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Proprotein convertase subtilisin/kexin type 9 (PCSK9), the last member of the proprotein convertase family, functions as a classic regulator of low-density lipoprotein (LDL) by interacting with low-density lipoprotein receptor (LDLR). Recent studies have shown that PCSK9 can affect the occurrence and development of tumors and can be used as a novel therapeutic target. However, a comprehensive pan-cancer analysis of PCSK9 has yet to be conducted.
13p vishanshan 27-06-2024 1 1 Download
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Investigating novel therapeutic strategies for colorectal cancer (CRC) is imperative. However, there is limited research on the use of drugs to target peripheral blood immune cells in this context. To address this gap, we performed a two-sample Mendelian randomization (MR) analysis to identify potential therapeutic targets for CRC.
14p vikoch 27-06-2024 1 1 Download
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Glioblastoma (GBM) is an aggressive brain tumor that exhibits resistance to current treatment, making the identification of novel therapeutic targets essential. In this context, cellular prion protein (PrPC ) stands out as a potential candidate for new therapies.
17p vikoch 27-06-2024 3 1 Download
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Ebook "Biomedical nanotechnology: Methods and protocols" is to provide an overview of biomedical nanotechnology, from the conception of novel materials in the laboratory to the application of such structures in the clinic. After a brief introductory chapter, the first section consists of protocol chapters which provide practical information on the synthesis of a variety of solution-phase and surface-bound nanomaterials and their application in sensing, imaging, and/or therapeutics; most chapters provide step-by-step instructions and insight into overcoming possible pitfalls and challenges.
447p dongmelo 27-05-2024 3 2 Download
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Ebook "Forkhead transcription factors: Vital elements in biology and medicine" provides a unique platform for the presentation of novel work and new insights into the vital role that forkhead transcription factors play in multiple systems throughout the body. Leading international authorities provide their knowledge and insights to offer a novel perspective for translational medicine that highlights the role of forkhead genes and proteins that may have the greatest impact for the development of new strategies for a broad array of disorders.
283p ladongphongthanh1008 22-04-2024 3 2 Download
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Ebook "Current topics in complement II" to discuss recent advances in this rapidly-evolving field. This volume represents a collection of topics on the “novel” functions of complement, pathophysiology, protein structures, and complement therapeutics discussed during the conference.
333p ladongphongthanh1008 22-04-2024 3 1 Download
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Ebook "Current advances in osteosarcoma" summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and it is also the most common histological form of bone cancer. It accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents.
358p tracanhphuonghoa1007 22-04-2024 6 1 Download
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Genomic medicine has considerable potential to provide novel diagnostic and therapeutic solutions for patients who have molecularly complex diseases and who are not responding to existing therapies. To bridge the gap between genomic medicine and clinical practice, integration of various data types, resources, and joint international initiatives will be required.
3p vibransone 28-03-2024 3 2 Download
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Next-generation sequencing (NGS) of cancer gene panels are widely applied to enable personalized cancer therapy and to identify novel oncogenic mutations. Methods: We performed targeted NGS on 932 clinical cases of non-small-cell lung cancers (NSCLCs) using the Ion AmpliSeq™ Cancer Hotspot panel v2 assay.
11p vioraclene 31-03-2024 3 2 Download
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Medulloblastoma (MB) is the most common malignant paediatric brain tumour and a leading cause of cancer-related mortality and morbidity. Existing treatment protocols are aggressive in nature resulting in significant neurological, intellectual and physical disabilities for the children undergoing treatment. Thus, there is an urgent need for improved, targeted therapies that minimize these harmful side effects.
15p vibransone 28-03-2024 4 2 Download
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Liver cancer is one of the most commonly diagnosed cancers and the fourth leading cause of cancerrelated death worldwide. Broad-spectrum kinase inhibitors like sorafenib and lenvatinib provide only modest survival benefit to patients with hepatocellular carcinoma (HCC). This study aims to identify novel therapeutic strategies for HCC patients.
15p vibransone 28-03-2024 1 1 Download
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Ebook "Recent trends in biotechnology and therapeutic applications of medicinal plants" provides an overview of current trends in biotechnology and medicinal plant sciences. The work includes detailed chapters on various advance biotechnological tools involved in production of phytoactive compounds of medicinal significance. Some recent and novel research studies on therapeutic applications of different medicinal plants from various geographical regions of the world have also been included.
359p coduathanh1122 27-03-2024 2 1 Download
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Ebook "Biology and management of unusual plasma cell dyscrasias" focuses on the non-myeloma plasma cell dyscrasias. A key resource for this group of diseases, the book features the latest in emerging knowledge and therapeutic developments, including novel therapies. Each disease-specific chapter discusses biology, disease course, and appropriate therapeutic interventions, covering plasma cell leukemia, plasmacytoma, POEMS Syndrome and Castleman's Disease, Waldenström macroglobulinemia, immunoglobin deposition disease, and cryoglobulinemic syndromes, among others.
207p cotieubac1004 15-03-2024 0 0 Download
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Ebook "Bioactive sphingolipids in cancer biology and therapy" presents information on both the basic and clinical aspects of sphingolipid-metabolizing enzymes in various cancers. The volume also includes discussions of the innovative techniques and approaches for quantitative analysis and imaging that could significantly impact the general understanding of this topic, and the potential benefit of targeting sphingolipid enzymes to develop novel cancer therapeutics.
491p cotieubac1004 15-03-2024 2 0 Download
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Novel immunotherapy combination therapies have improved outcomes for patients with hepatocellular carcinoma (HCC), but responses are limited to a subset of patients. Little is known about the inter- and intra-tumor heterogeneity in cellular signaling networks within the HCC tumor microenvironment (TME) that underlie responses to modern systemic therapy.
14p vicwell 29-02-2024 6 2 Download
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Alternative splicing complexity plays a vital role in carcinogenesis and cancer progression. Improved understanding of novel splicing events and the underlying regulatory mechanisms may contribute new insights into developing new therapeutic strategies for colorectal cancer (CRC).
24p vicwell 29-02-2024 2 2 Download