Novel
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In this paper, two silica-based geopolymer matrix systems reinforced composites were synthesized and fabricated at optimal conditions. The composites contained approximately 40 wt.% of Carbon HTA twill (TohoTenax) and 48 wt.% of advanced S-glass twill (Saint-Gobain, Vetrotex), respectively.
9p vijaychest 24-04-2024 1 1 Download
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The paper "A novel approach of neural networks and USLE in smart soil erosion modeling, case study in Southern coastal of Viet Nam" adopted one of the neural networks - the Long ShortTerm Memory (LSTM) to analyze temporal variations in erosion patterns over time, aiding in understanding erosion dynamics. Furthermore, another common soil erosion model - the Universal Soil Loss Equation (USLE) was investigated to predict annual soil loss. Our data were extracted from remotely sensed data (DEM - Digital Elevation Model and MODIS) and vector data of the study area.
11p tukhauquantuong1011 22-04-2024 2 1 Download
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The synthesized compounds' enzyme inhibition potential was tested against a-glucosidase, AChE, and BChE enzymes. As illustrated from the results of IC50, these compounds are observed as the active inhibitory potential for these enzymes. The cytotoxic activity by hemolytic Assay revealed that these compounds have mild exposure to cytotoxicity on RBCs.
10p visergey 02-04-2024 0 0 Download
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In this paper, we introduce a novel simulation-based optimization method, CMAESEP, which couples the Covariance Matrix Adaptation Evolution Strategy Optimization Algorithm and the Epanet hydraulic simulator for optimal designing water distribution networks. The proposed method is applied to the published benchmark water network of Hanoi.
10p vilarry 01-04-2024 1 1 Download
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The present study aims to identify Neofusicoccum isolates collected from lotus with symptoms of dieback, blight, and wilted leaves. Species were identified based on their morphology and comparison of the DNA sequence data for ITS rDNA and β-tubulin (tub-2). The taxonomy and phylogenetic relationships of pathogen isolates were investigated, and their pathogenic abilities were determined.
17p viritesh 02-04-2024 2 1 Download
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The goal of the workshop was not to focus on specific, even novel mechanisms, rather on the interfaces between mechanisms in different technical and social problem spaces. 21 people from different parts of the world took part in the one-day discussion, including PhD students, seasoned and junior researchers. This workshop promises to be a lasting experience and we encourage researchers to participate in future events. We hope that you will find its proceedings useful and valuable to read.
182p longtimenosee05 31-03-2024 0 0 Download
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Large-sequencing cancer genome projects have shown that tumors have thousands of molecular alterations and their frequency is highly heterogeneous. In such scenarios, physicians and oncologists routinely face lists of cancer genomic alterations where only a minority of them are relevant biomarkers to drive clinical decisionmaking.
11p vibransone 28-03-2024 2 2 Download
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Heterotaxy (Htx) syndrome comprises a class of congenital disorders resulting from malformations in left-right body patterning. Approximately 90% of patients with heterotaxy have serious congenital heart diseases; as a result, the survival rate and outcomes of Htx patients are not satisfactory.
13p vibransone 28-03-2024 2 2 Download
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Genome–phenome studies have identified thousands of variants that are statistically associated with disease or traits; however, their functional roles are largely unclear. A comprehensive investigation of regulatory mechanisms and the gene regulatory networks between phenome-wide association study (PheWAS) and genomewide association study (GWAS) is needed to identify novel regulatory variants contributing to risk for human diseases.
15p vibransone 28-03-2024 2 2 Download
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Unraveling functional noncoding variants associated with complex diseases is still a great challenge. We present a novel algorithm, Prioritization And Functional Assessment (PAFA), that prioritizes and assesses the functionality of genetic variants by introducing population differentiation measures and recalibrating training variants.
18p vibransone 28-03-2024 1 1 Download
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Comprehensive mutational profiling data now available on all major cancers have led to proposals of novel molecular tumor classifications that modify or replace the established organ- and tissue-based tumor typing. The rationale behind such molecular reclassifications is that genetic alterations underlying cancer pathology predict response to therapy and may therefore offer a more precise view on cancer than histology.
17p vibransone 28-03-2024 3 2 Download
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In recent years, research has consistently proven the occurrence of genetic overlap across autoimmune diseases, which supports the existence of common pathogenic mechanisms in autoimmunity. The objective of this study was to further investigate this shared genetic component.
13p vibransone 28-03-2024 3 2 Download
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Genomic medicine has considerable potential to provide novel diagnostic and therapeutic solutions for patients who have molecularly complex diseases and who are not responding to existing therapies. To bridge the gap between genomic medicine and clinical practice, integration of various data types, resources, and joint international initiatives will be required.
3p vibransone 28-03-2024 3 2 Download
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Intrachromosomal triplications (TRP) can contribute to disease etiology via gene dosage effects, gene disruption, position effects, or fusion gene formation. Recently, post-zygotic de novo triplications adjacent to copynumber neutral genomic intervals with runs of homozygosity (ROH) have been shown to result in uniparental isodisomy (UPD).
14p vibransone 28-03-2024 3 2 Download
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A major advance in antimalarial drug discovery has been the shift towards cell-based phenotypic screening, with notable progress in the screening of compounds against the asexual blood stage, liver stage, and gametocytes. A primary method for drug target deconvolution in Plasmodium falciparum is in vitro evolution of compound-resistant parasites followed by whole-genome scans.
17p vibransone 28-03-2024 6 1 Download
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The resurgence of immune therapies in cancer medicine has elicited a corresponding interest in understanding the basis of patient response or resistance to these treatments. One aspect of patient response clearly lies in the genomic alterations that are associated with cancer onset and progression, including those that contribute to genomic instability and the resulting creation of novel peptide sequences that may present as neoantigens.
12p vibransone 28-03-2024 2 2 Download
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Whole-exome sequencing (WES) has become an efficient diagnostic test for patients with likely monogenic conditions such as rare idiopathic diseases or sudden unexplained death. Yet, many cases remain undiagnosed. Here, we report the added diagnostic yield achieved for 101 WES cases re-analyzed 1 to 7 years after initial analysis.
8p vibransone 28-03-2024 3 2 Download
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Modern medicine is rapidly moving towards a data-driven paradigm based on comprehensive multimodal health assessments. Integrated analysis of data from different modalities has the potential of uncovering novel biomarkers and disease signatures.
14p vibransone 28-03-2024 2 2 Download
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Carbapenem-resistant Enterobacteriaceae are considered by WHO as “critical” priority pathogens for which novel antibiotics are urgently needed. The dissemination of carbapenemase-producing Escherichia coli (CP-Ec) in the community is a major public health concern. However, the global molecular epidemiology of CP-Ec isolates remains largely unknown as well as factors contributing to the acquisition of carbapenemase genes.
18p vibransone 28-03-2024 2 1 Download
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Clear cell renal cell carcinoma (ccRCC) is the dominant subtype of renal cancer. With currently available therapies, cure of advanced and metastatic ccRCC is achieved only in rare cases. Here, we developed a workflow integrating different -omics technologies to identify ccRCC-specific HLA-presented peptides as potential drug targets for ccRCC immunotherapy.
24p vibransone 28-03-2024 1 1 Download