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Nuclear mitochondria DNA
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POLG, located on nuclear chromosome 15, encodes the DNA polymerase γ(Pol γ). Pol γ is responsible for the replication and repair of mitochondrial DNA (mtDNA). Pol γ is the only DNA polymerase found in mitochondria for most animal cells. Mutations in POLG are the most common single-gene cause of diseases of mitochondria and have been mapped over the coding region of the POLG ORF.
16p
vihagrid
30-01-2023
5
3
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Most genetic analyses of ancient and modern dogs have focused on variation in the autosomes or on the mitochondria. Mitochondrial DNA is more easily obtained from ancient samples than nuclear DNA and mitochondrial analyses have revealed important insights into the evolutionary history of canids. Utilizing a recently published dog Y-chromosome reference, we analyzed Y-chromosome sequence across a diverse collection of canids and determined the Y haplogroup of three ancient European dogs.
9p
vibeauty
23-10-2021
9
0
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The safety of genetically transformed plants remains a subject of scrutiny. Genomic variants in PRSV resistant transgenic papaya will provide evidence to rationally address such concerns.
21p
vijeeni2711
24-07-2021
12
0
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Whole-genome sequencing (WGS) projects provide short read nucleotide sequences from nuclear and possibly organelle DNA depending on the source of origin. Mitochondrial DNA is present in animals and fungi, while plants contain DNA from both mitochondria and chloroplasts.
7p
viconnecticut2711
29-10-2020
7
2
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Systemic autoimmune diseases (SAD) are the diseases where multiple organs are involved in the presence of a large variety of auto antibodies directed against sub-cellular structures or molecules (E.g. nuclei, cytoplasm, mitochondria, DNA) and are characterized by presence of Antinuclear antibodies (ANA). Indirect immunofluorescence Assay (IIFA) on Hep-2 (human epithelial cell tumour line) is a classical technique for detection of ANA and is considered as “gold standard”.
6p
angicungduoc5
14-06-2020
12
0
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Complex IV is the terminal enzyme of the mitochondrial respiratory chain. In humans, biogenesis of complex IV involves the coordinated assembly of 13 subunits encoded by both mitochondrial and nuclear genomes. The early stages of complex IV assembly involving mitochondrial DNA-encoded subunits CO1 and CO2 have been well studied.
13p
viettel02
20-02-2013
29
2
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