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Observational cohort study
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Despite numerous studies on racial/ethnic disparities among patients with breast cancer, there is a paucity of literature evaluating racial/ethnic differences in 21-gene recurrence score (RS) and survival diferences stratifed by RS risk categories. We thus performed an observational cohort study to examine racial/ethnic disparities in the context of RS.
8p
vishanshan
27-06-2024
1
1
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Checkpoint inhibitors (CPIs) are widely used in cancer treatment, with transformative impacts on survival. They nonetheless carry a significant risk of toxicity in the form of immune-related adverse events (IrAEs), which may be sustained and life-altering. IrAEs may require high-dose and/or prolonged steroid use and represent a significant healthcare burden.
11p
vikoch
27-06-2024
1
1
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Hepatic proteins, including albumin, prealbumin, and transferrin have been confirmed to be prognostic predictors in various cancers. This study aimed to comprehensively assess the prognostic value of these three serum markers in patients with cancer cachexia.
12p
vikoch
27-06-2024
1
1
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We investigated the features of the genomic rearrangements in a cohort of 50 male individuals with proteolipid protein 1 (PLP1) copy number gain events who were ascertained with Pelizaeus-Merzbacher disease (PMD; MIM: 312080). We then compared our new data to previous structural variant mutagenesis studies involving the Xq22 region of the human genome.
17p
vibransone
28-03-2024
4
2
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Large-scale trials have shown that hypofractionated adjuvant breast radiotherapy was as effective in terms of survival and local control as conventional fractionated radiotherapy, and acute toxicity was reduced with hypofractionated radiotherapy.
10p
vileonardodavinci
23-12-2023
3
2
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Traditional observational studies have shown an inverse association between body mass index (BMI) and lung cancer risk. Mendelian randomization (MR) analysis using genetic variants as instruments for BMI may clarify the nature of the association. We studied the causal association between BMI and lung cancer incidence using observational and MR approaches.
10p
vileonardodavinci
23-12-2023
10
4
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Protocol of the Comparison of Intravesical Therapy and Surgery as Treatment Options (CISTO) study: A pragmatic, prospective multicenter observational cohort study of recurrent high-grade non-muscle invasive bladder cancer
12p
vileonardodavinci
23-12-2023
2
2
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This study, therefore, examined both the long-term treatment patterns and overall survival (OS) in a regional Swedish cohort of female patients with metastatic breast cancer stratified by subtype in routine clinical practice during a recent eight-year period and correlation to current treatment guidelines.
12p
vialfrednobel
23-12-2023
6
3
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Concomitant diseases often occur in cancer patients and are important in decision-making regarding treatments. However, information regarding the prognostic relevance of comorbidities for mortality risk is still limited among Chinese gastric cancer (GC) patients. This study aimed to investigate the association between comorbidities and 3-year mortality risk.
11p
vioracle
29-09-2023
5
3
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To study the effect on patient cohorts of mapping condition (diagnosis) codes from source billing vocabularies to a clinical vocabulary. It appears possible to map diagnoses from disparate vocabularies to a single clinical vocabulary and carry out research using a single set of definitions, thus improving efficiency and transportability of research.
8p
visteverogers
24-06-2023
4
2
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This study used data from three CVH cohorts to examine longitudinally the associations of a resilience resource, perceived neighborhood social cohesion (hereafter referred to as neighborhood social cohesion), with the American Heart Association’s Life’s Simple 7 (LS7), and whether psychosocial stressors modify observed relationships.
11p
viferrari
29-10-2022
7
2
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Immunotherapy has become a new therapy for advanced hepatocellular carcinoma (HCC); however, its treatment results are considerably different. CD4+ T cells (CD4+) are the key to immunotherapy, but patients with HCC that have low CD4+ are rarely observed for clinical evidence.
10p
vikolindagrabar
27-07-2022
3
1
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As opposed to observation of the neck, elective neck dissection has a survival benefit for cN0 oropharyngeal squamous cell carcinoma (OPSCC). However, there are limited date on level IV neck dissection in human papillomavirus (HPV)-negative OPSCC because most earlier studies did not stratify by P16 or HPV status.
10p
vikolindagrabar
27-07-2022
5
2
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Poor cancer prognosis has been observed in patients with pre-existing psychiatric disorders. Therefore, we need better knowledge about the diagnosis of cancer in this patient group. The aim of the study was to describe the routes to cancer diagnosis in patients with pre-existing psychiatric disorders and to analyse how cancer type modified the routes.
12p
vikolindagrabar
27-07-2022
5
1
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Transarterial chemoembolization (TACE) is the standard treatment for intermediate stage hepatocellular carcinoma (HCC) (Barcelona Clinic Liver Cancer [BCLC] B). However, it often leads to a poor prognosis and decreased hepatic function especially in patients with BCLC substage B2.
9p
vikolindagrabar
27-07-2022
3
1
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Demographic aging is a generalised event and the proportion of older adults is increasing rapidly worldwide with chronic pathologies, disability, and complexity of health needs. The intracerebral haemorrhage (ICH) has devastating consequences in high risk people. This study aims to quantify the incidence of ICH in complex chronic patients (CCP).
13p
viisaacnewton
25-04-2022
12
4
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This study aimed to prospectively analyze the risk factors for new falls and fragility fractures in selfcaring elderly patients and to find suitable evaluation tools for community screening and follow-up interventions. Methods: A total of 300 participants (187 male and 113 female), aged 80 or above and capable of caring for themselves, were enrolled in this study and observed for a period of 12 months.
9p
viisaacnewton
25-04-2022
18
4
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The role of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) as a prognostic factor in patients admitted to the intensive care unit (ICU) is not yet fully established. We aimed to determine whether NT-pro-BNP is predictive of ICU mortality in a multicenter cohort of critically ill patients.
9p
viisaacnewton
26-04-2022
7
1
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The prognostic value of biochemical tests in critically ill patients with multiple organ failure and suspected bowel ischemia is unknown. Methods: In a prospective observational cohort study intensive care patients were included when the attending intensivist considered intestinal ischemia in the diagnostic workup at any time during intensive care stay.
10p
viisaacnewton
26-04-2022
8
1
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Decreases in prevalence of cognitive impairment and dementia over the last two decades have been observed in different countries for cohorts entering older age. This study aimed to assess the cognitive impairment prevalence and explore associated factors among subjects aged >60 living in São Paulo, Brazil.
10p
vinobelprisen
26-03-2022
8
4
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