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Oncogenic viruses
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In ebook "Genome instability in cancer development" studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These important findings not only explain the occurrence of certain hereditary tumours, but they also set the stage for the development of anti-cancer drugs that specifically target activated oncogenes.
509p
tracanhphuonghoa1007
22-04-2024
2
1
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Part 1 book "Cancer biology" includes content: What is cancer; natural history - the life of a cancer; pathology - Defining a neoplasm; epidemiology - identifying causes for human cancers; oncogenes, tumour suppressor genes and viruses, chemical and radiation carcinogenesis; mutations, DNA repair and genetic instability.
146p
muasambanhan02
25-12-2023
2
2
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Part 1 book "Fish diseases and disorders (Vol 3: Viral, bacterial and fungal infections)" includes content: Infectious pancreatic necrosis and associated aquatic birnaviruses; infectious haematopoietic necrosis virus; viral haemorrhagic septicaemia; infectious salmon anaemia; viral diseases and agents of warmwater fish; salmonid alphaviruses; oncogenic viruses and oncorhynchus masou virus; piscirickettsia, francisella and epitheliocystis; bacterial kidney disease (renibacterium salmoninarum); enterococcus seriolicida and Streptococcus spp. (S. iniae, S. agalactiae and S. dysgalactiae).
406p
muasambanhan01
11-12-2023
7
3
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Part 1 book "Fish viruses and bacteria - Pathobiology and protection" includes content: Infectious pancreatic necrosis virus, infectious haematopoietic necrosis virus; viral haemorrhagic septicaemia virus; epizootic haematopoietic necrosis and european catfish virus; oncogenic viruses - oncorhynchus masou virus and cyprinid herpesvirus; infectious salmon anaemia; spring viraemia of carp; channel catfish viral disease; largemouth bass viral disease,... and other conetnts.
185p
oursky10
04-12-2023
8
4
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The advent of immunotherapies has ushered in a new era in the treatment of non-small cell lung carcinoma. Although immunotherapies are associated with improved clinical outcomes, studies report a median overall survival of 11 months with progression-free survival of 2.5 months with the use of nivolumab for pretreated metastatic non-small cell lung cancer.
6p
vigamora
23-05-2023
7
3
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Marek’s disease (MD) is caused by the oncogenic Marek’s disease virus (MDV), and is a highly contagious avian infection with a complex underlying pathology that involves lymphoproliferative neoplasm formation.
9p
vigalileogalilei
28-02-2022
10
1
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Friend leukemia virus integration 1 (FLI1), an ETS transcription factor family member, acts as an oncogenic driver in hematological malignancies and promotes tumor growth in solid tumors. However, little is known about the mechanisms underlying the activation of this proto-oncogene in tumors.
14p
vigalileogalilei
27-02-2022
12
1
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Marek’s disease (MD) is a chicken neoplastic disease, which brings huge economic losses to the global poultry industry. The wild type p53, a tumor suppressor gene, plays a key role in blocking cell cycle, promoting apoptosis, and maintaining the stability of the genome. However, the mutant p53 losses its tumor inhibitory role and become an oncogene when a mutation has happened.
7p
vigandhi
23-02-2022
5
1
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Marek’s disease (MD) is a lymphoproliferative disease caused by Gallid alphaherpesvirus 2 (GaHV-2, MDV-1), which primarily affects chickens. However, the virus is also able to induce tumors and polyneuritis in turkeys, albeit less frequently than in chickens.
10p
vidarwin
22-02-2022
8
1
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Low-risk human papillomavirus (HPV), such as types 6 and 11, is considered non-oncogenic, but these types have been detected in oral cancer tissue samples, suggesting their possible involvement in oral carcinogenesis. Because double infection of high-risk HPV and Epstein-Barr virus (EBV) is known to be involved in oral carcinogenesis, we hypothesized that low-risk HPV and EBV co-infection can transform the oral cells.
13p
vimahuateng
26-11-2021
7
1
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Hepatitis B Virus (HBV) contributes to liver carcinogenesis via various epigenetic mechanisms. The newly defined epigenetics, epitranscriptomics regulation, has been reported to involve in multiple cancers including Hepatocellular Carcinoma (HCC). Our previous study found that HBx, HBV encodes X protein, mediated H3K4me3 modification in WDR5-dependent manner to involve in HBV infection and contribute to oncogene expression.
11p
vimahuateng
26-11-2021
6
1
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Marek’s disease virus (MDV) is an oncogenic herpesvirus that can cause T-cell lymphomas in chicken. Long noncoding RNA (lncRNA) is strongly associated with various cancers and many other diseases. In chickens, lncRNAs have not been comprehensively identified.
15p
visilicon2711
20-08-2021
6
1
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The main objectives of this study includes to assessment of HHV-8 DNA prevalence in women with breast cancer recognized cancer-causing viruses in humans [8]. In 2010, HHV-8 was identified as a group 1 carcinogen by the International Agency for Research on Cancer (IARC) due to its specific public health threat related to its oncogenic potential [9].
8p
gaocaolon9
22-12-2020
7
2
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High-risk human papillomavirus type 16 (HPV16) is a risk factor for cervical cancer. Previous studies suggest that polymorphisms in the E6 gene or the long control region (LCR)of HPV16 may alter the oncogenic potential of the virus.
8p
vijennie2711
29-09-2020
9
1
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EBV-encoded latent membrane protein 1 (EBV-LMP1) is an important oncogenic protein for nasopharyngeal carcinoma (NPC) and has been shown to engage a plethora of signaling pathways. Correspondingly, an LMP1-targeted DNAzyme was found to inhibit the growth of NPC cells both in vivo and in vitro by suppressing cell proliferation and inducing apoptosis.
9p
vilisa271
22-09-2020
12
2
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Since the beginning of the twentieth century, infection has emerged as a fundamental aspect of cancer causation with a growing number of pathogens recognized as oncogenic. Meanwhile, oncolytic viruses have also attracted considerable interest as possible agents of tumor destruction.
11p
vimale2711
21-08-2020
10
1
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Bmi-1, the B cell-specific moloney murine leukemia virus insertion site 1, is a member of the Polycomb-group (PcG) family and acts as an oncogene in various tumors; however, its expression related to the prognosis of pediatric patients with acute lymphoblastic leukemia (ALL) has not been well studied.
8p
vimale2711
21-08-2020
10
1
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Genetic alterations, including mutation of epidermal growth factor receptor or v-Ki-ras2 kirsten rat sarcoma viral oncogene homolog and fusion of anaplastic lymphoma kinase (ALK), RET proto-oncogene (RET), or vros UR2 sarcoma virus oncogene homolog 1 (ROS1), occur in non-small cell lung cancers, and these oncogenic drivers are important biomarkers for targeted therapies.
10p
viputrajaya2711
22-06-2020
29
1
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CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell
Aberrant spliced isoforms are specifically associated with cancer progression and metastasis. The cytoplasmic adaptor CRKL (v-crk avian sarcoma virus CT10 oncogene homolog-like) is a CRK like proto-oncogene, which encodes a SH2 and SH3 (src homology) domain-containing adaptor protein.
16p
vikuala271
13-06-2020
7
1
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Cervical carcinoma (CA cervix) is the fourth most common cause of death and the second most common cancer in women world-wide. It is a slowly progressing neoplasm that may take 10-20 years to manifest. CA cervix is one of the few vaccine-preventable cancers because it is caused almost exclusively by an exogenous infective agent, the Human Papilloma Virus (HPV). Among the high-risk strains, strains 16, 18, 45, 31, 33, 35, 39, 51, 52, 56, 58, 59 and 68 are most commonly associated with cervical cancer.
10p
chauchaungayxua3
07-02-2020
13
0
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