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Oxidative cyclization
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Ebook "Chemistry of 1,2,3-triazoles (Topics in Heterocyclic chemistry, Volume 40)" has been an important topic in heterocyclic chemistry since the first such heterocycles were prepared in the nineteenth century by von Pechmann (1888). Publications on triazoles have increased steadily ever since but there has recently been a remarkable additional interest due to the CuAAC (copper-catalyzed acetylene/azide cycloaddition) discovered by Meldal and Sharpless and related azide cycloaddition reactions, leading to a surge of publications and new applications for triazoles.
389p
tudohanhtau1006
29-03-2024
6
1
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Two series of 6-arylazothiazol[2,3-c][1,2,4]triazoles were prepared via oxidative cyclization of the respective aldehyde N-(5-arylazo-4-methylthiazol-2-yl)-hydrazones. The structures of the latter hydrazone precursors and the azo compounds were confirmed by spectral and elemental analyses. The solvatochromism of the title azo dyes is evaluated by means of the Kamlet–Taft equation and discussed.
9p
langthannam
29-12-2021
6
0
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A facile synthesis of bis-thiazoles, bis-pyrazoles, and bis-hydrazonates from the reaction of bis-hydrazonoyl dichlorides with different moieties is described. Bis-triazolothiadiazoles were synthesized via oxidative cyclization of bis-hydrazones. Structures of the final product were elucidated by elemental analyses and spectral data.
10p
langthannam
29-12-2021
3
0
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An efficient synthetic route for a novel series of chalcones 2a–2d as well as for the corresponding flavanones 3a–3d and flavones 4a–4d, using functionalized tetrahydronaphthalene (THN), is described herein. The Claisen– Schmidt condensation of such THN and aromatic aldehydes, in the presence of an aqueous solution of KOH (40%), selectively gives the expected chalcones 2a–2d, which may further undergo an intramolecular oxa-Michael addition using piperidine, affording the corresponding flavanones 3a–3d in high yields.
71p
tudichquannguyet
29-11-2021
8
1
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In this work, an attempt to planarize 2,3,4,6- tetraarylthieno[3,2-b]thiophene based on the FeCl3 oxidative annulation was described. Thus, two cyclized 2,3,5,6-tetraarylthieno[3,2-b]thiophenes 5a and 5b were synthesized in moderate yields. NMR and HR-MS analysis indicated the annulation between only one pair of the phenyl substituents.
8p
tamynhan9
02-12-2020
11
2
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Recently, some of the furoquinoline alkaloids were found to have an interesting biological activity, for example, anti-cancer, antiplatelet aggregation and antifungal activities. The interesting biological activity made these compounds 1-13 attractive targets in organic chemistry. A novel generally applicable synthesis of furoquinolines is described. The condensation of 2- methoxy aniline and malonic acid in the presence of POCl3 gave 2,4-dichloro-8- methoxyquinoline. Then, treatment of this compound with sodium methoxide in methanol under reflux afforded 4,8-dimethoxyquinoline.
5p
uocvong04
24-09-2015
66
4
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Besides the post-translationally cyclizing catalytic Ala-Ser-Gly triad, Tyr110 and its equivalents are of the most conserved residues in the active site of phenylalanine ammonia-lyase (PAL, EC 4.3.1.5), histidine ammonia-lyase (HAL, EC 4.3.1.3) and other related enzymes. The Tyr110Phe muta-tion results in the most pronounced inactivation of PAL indicating the importance of this residue.
16p
inspiron33
26-03-2013
42
4
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Jasmonates are derived from oxygenated fatty acids (oxylipins) via the octadecanoid pathway and are characterized by a pentacyclic ring struc-ture. They have regulatory functions as signaling molecules in plant devel-opment and adaptation to environmental stress.
14p
media19
06-03-2013
34
2
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