![](images/graphics/blank.gif)
Pantothenate synthetase
-
The study describes the synthesis, characterization, in vitro antimicrobial and anticancer evaluation of a series of 2-(1-benzoyl-1H-benzo[d]imidazol-2-ylthio)-N-substituted acetamide derivatives. The synthesized derivatives were also assessed for in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv.
14p
vijiraiya2711
27-05-2020
15
1
Download
-
In bacteria, coenzyme A is synthesized in five steps from D-pantothenate. The Dfp flavoprotein catalyzes the synthe-sis of the coenzyme A precursor 4¢-phosphopantetheine from 4¢-phosphopantothenate and cysteine using the cofac-tors CTP and flavine mononucleotide via the phospho-peptide-like compound 4¢-phosphopantothenoylcysteine. The synthesis of 4¢-phosphopantothenoylcysteine is cata-lyzedby theC-terminal CoaBdomainofDfp andoccurs via the acyl-cytidylate intermediate 4¢-phosphopantothenoyl-CMP in two half reactions. ...
10p
dell39
03-04-2013
35
2
Download
-
The linear biosynthetic pathway leading froma-ketoisovalerate to panto-thenate (vitamin B5) and on to CoA comprises eight steps in the Bacteria and Eukaryota. Genes for up to six steps of this pathway can be identified by sequence homology in individual archaeal genomes.
11p
media19
06-03-2013
34
2
Download
-
The structural basis for the homotropic inhibition of pantothenate synthe-tase by the substrate pantoate was investigated by X-ray crystallography and high-resolution NMR spectroscopic methods. The tertiary structure of the dimeric N-terminal domain of Escherichia colipantothenate synthetase, determined by X-ray crystallography to a resolution of 1.7 A˚ , showed a second molecule of pantoate bound in the ATP-binding pocket.
16p
mobifone23
18-01-2013
47
3
Download
CHỦ ĐỀ BẠN MUỐN TÌM
![](images/graphics/blank.gif)