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Polygenic variations
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The etiology of ASD involves both inherited and environmental risk factors, with epigenetic processes hypothesized as one mechanism by which both genetic and non-genetic variation influence gene regulation and pathogenesis. The aim of this study was to identify DNA methylation biomarkers of ASD detectable at birth.
13p
vibransone
28-03-2024
3
2
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Genome-wide association studies of Alzheimer’s disease (AD) have identified a number of significant risk loci, the majority of which lie in non-coding regions of the genome. The lack of causal alleles and considerable polygenicity remains a significant barrier to translation into mechanistic understanding.
10p
vibransone
28-03-2024
1
1
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Depression is a disabling and highly prevalent condition where genetic and epigenetic, such as DNA methylation (DNAm), differences contribute to disease risk. DNA methylation is influenced by genetic variation but the association between polygenic risk of depression and DNA methylation is unknown.
16p
viellison
28-03-2024
3
2
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High-resolution mapping of the loci (QTN) responsible for genetic variation in quantitative traits is essential for positional cloning of candidate genes, and for effective marker assisted selection. The confidence interval (QTL) flanking the point estimate of QTN-location is proportional to the number of individuals in the mapping population carrying chromosomes recombinant in the given interval.
16p
vinarcissa
21-03-2023
2
1
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Horizontal pleiotropy, where one variant has independent effects on multiple traits, is important for our understanding of the genetic architecture of human phenotypes. We develop a method to quantify horizontal pleiotropy using genome-wide association summary statistics and apply it to 372 heritable phenotypes measured in 361,194 UK Biobank individuals. Horizontal pleiotropy is pervasive throughout the human genome, prominent among highly polygenic phenotypes, and enriched in active regulatory regions.
18p
vielonmusk
30-01-2022
8
0
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A framework for transcriptome-wide association studies in breast cancer in diverse study populations
The relationship between germline genetic variation and breast cancer survival is largely unknown, especially in understudied minority populations who often have poorer survival. Genome-wide association studies (GWAS) have interrogated breast cancer survival but often are underpowered due to subtype heterogeneity and clinical covariates and detect loci in non-coding regions that are difficult to interpret.
18p
viarchimedes
26-01-2022
14
1
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LPG: A four-group probabilistic approach to leveraging pleiotropy in genome-wide association studies
To date, genome-wide association studies (GWAS) have successfully identified tens of thousands of genetic variants among a variety of traits/diseases, shedding light on the genetic architecture of complex disease. The polygenicity of complex diseases is a widely accepted phenomenon through which a vast number of risk variants, each with a modest individual effect, collectively contribute to the heritability of complex diseases. This imposes a major challenge on fully characterizing the genetic bases of complex diseases.
11p
vibeauty
23-10-2021
8
0
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The gBLUP method was used due to its computational efficiency and it showed similar predictive performance to other approaches, especially for traits whose variation is of polygenic nature, such as body traits analysed in this study. The accuracy or predictive ability of the gBLUP model was estimated for three growth traits: body weight, folk length and condition index.
9p
vibeauty
23-10-2021
11
0
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Quantitative red blood cell (RBC) traits are highly polygenic clinically relevant traits, with approximately 500 reported GWAS loci. The majority of RBC trait GWAS have been performed in European- or East Asian-ancestry populations, despite evidence that rare or ancestry-specific variation contributes substantially to RBC trait heritability.
14p
vijeeni2711
24-07-2021
12
0
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The accumulation of intracellular fat depots is a polygenic trait. Therefore, the extent of lipid storage in the individuals of a species covers a broad range and is determined by many genetic factors
15p
vilichoo2711
25-06-2021
10
1
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Systemic sclerosis (SSc) is a rheumatologic disease with a multifactorial etiology. Genome-wide association studies imply a polygenic, complex mode of inheritance with contributions from variation at the human leukocyte antigen locus and non-coding variation at a locus on chromosome 6p21, among other modestly impactful loci.
6p
vitennessee2711
02-02-2021
6
2
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Breeding for high yield crops require information on nature and magnitude of variation in the available material, relationship of yield with other agronomic characters and the degree of environmental influence on the expression of these component characters. Since grain yield in rice is quantitative in nature and polygenically controlled, effective yield improvement and simultaneous improvement of yield components are imperative.
8p
gaocaolon9
22-12-2020
18
1
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Five mungbean varieties released by Punjab Agricultural University (PAU911, SML668, ML818, ML613 and SML832) were characterized using morphological and molecular markers. Phenotypically these varieties showed variation for growth habit, leaf and flower characters, pod colour, position and length, plant height, seed coat lusture and seed size during different growth stages of the crop. Plant morphology characters being polygenic in nature are liable to be influenced by the environment.
10p
trinhthamhodang1215
23-09-2020
15
1
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The upland cotton (Gossypium hirsutum L.) accounts for about 95% of world cotton production. Improving upland cotton cultivars has been the focus of worldwide cotton breeding programs. In cotton, seed cotton yield, yield contributing and fibre quality traits are under the control of polygenes or quantitative trait locus (QTL), for these traits QTL analysis holds a great promises these are the genomic regions that links the information between phenotypic (trait measurement) and genetic data (molecular markers) and explain the genetic basis of variation in complex traits.
24p
quenchua8
29-09-2020
14
0
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Genome Wide Association Studies (GWAS) have been recently used to dissect complex quantitative traits and identify candidate genes affecting phenotype variation of polygenic traits. In order to map loci controlling variation in tomato marketable and nutritional fruit traits, we used a collection of 96 cultivated genotypes, including Italian, Latin American, and other worldwide-spread landraces and varieties.
15p
viminato2711
22-05-2020
8
0
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Thirteen genotypes of early cauliflower were characterized for different quantitative parameters at the Vegetable Research Farm, at Bihar Agricultural University, Sabour during the Rabi season of 2010-2011 and 2011-2012. The experiment was laid out in a randomized complete block design with three replications. Pooled analysis of variance of the fifteen genotypes over two years indicated significant differences among the genotypes for all the characters under study.
11p
caygaocaolon2
14-03-2020
10
1
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Transgressive segregation produces hybrid progeny phenotypes that exceed the parental phenotypes. Unlike heterosis, extreme phenotypes caused by transgressive segregation are heritably stable. Maximum genetic variation in F2 generation provides the first opportunity for selection of individual plants, any one of which may end up into a new cultivar. F2 plants that surpassed the parental limits were observed in both the crosses for all the traits viz.
6p
chauchaungayxua3
07-02-2020
9
0
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Optimal psychological development is dependent upon a complex interplay between individual and situational factors. Investigating the development of these factors in adolescence will help to improve understanding of emotional vulnerability and resilience.
14p
vimadrid2711
19-12-2019
17
1
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Results suggested that due to its maximum heritability, early selection would be feasible in cross Hashim-08 × LU-26, while due to low heritability and variation in cross Parula × Blue Silver, delayed selection will be effective. Yield improvement based on duration of grain filling could be done through selection in later generations until the accumulation of the maximum favorable additive genes is achieved.
13p
danhdanh11
11-01-2019
12
1
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