Population structure inference

Alzheimer’s disease (AD) is characterized by neuronal loss and astrocytosis in the cerebral cortex. However, the specific effects that pathological mutations and coding variants associated with AD have on the cellular composition of the brain are often ignored.

19p vibransone 28-03-2024 3 2   Download

The utilization of biological data to infer the geographic origins of human populations has been a long standing quest for biologists and anthropologists. Several biogeographical analysis tools have been developed to infer the geographical origins of human populations utilizing genetic data.

11p vinarcissa 21-03-2023 3 1   Download

Indian agriculture is an economic symbiosis of crop and livestock production with cattle as the foundation. Sadly, the population of indigenous cattle (Bos indicus) is declining (8.94 % in last decade) and needs immediate scientific management. Genetic characterization is the first step in the development of proper management strategies for preserving genetic diversity and preventing undesirable loss of alleles.

12p vinarcissa 21-03-2023 4 1   Download

Increasingly available multilayered omics data on large populations has opened exciting analytic opportunities and posed unique challenges to robust estimation of causal effects in the setting of complex disease phenotypes.

7p vihagrid 30-01-2023 7 3   Download

Next-generation sequencing (NGS) of bulk tumour tissue can identify constituent cell populations in cancers and measure their abundance. This requires computational deconvolution of allelic counts from somatic mutations, which may be incapable of fully resolving the underlying population structure.

18p vialfrednobel 29-01-2022 16 0   Download

Ablepharus Lichtenstein, 1823, which includes ten species, is distributed in eastern Europe and Asia. Four species are recorded in Turkey: A. kitaibelii, A. chernovi, A. bivittatus, and A. budaki. After molecular and morphological studies in Anatolia, the phylogenetic relationship of the genus is still very complicated. Here, we investigate the taxonomic status of Ablepharus in Anatolia using morphological and molecular methods. The genetic structure of Ablepharus populations in Anatolia was analyzed using both the nuclear (CMOS) and mitochondrial (cyt b and COI) gene regions.

12p dolomite36 30-12-2021 16 1   Download

The significant negative neutrality test values are the evidence of expansion of the total population. H. sieboldiana and H. kiyosumiensis are more widely distributed than other taxa. H. sieboldiana, H. alismifolia, H. longipes var. gracillima and H. kikutii var. polyneuron showed the excessive low frequency variants.

10p schindler 30-12-2021 10 0   Download

Cowpea (Vigna unguiculata L. Walp) is an important legume crop due to its high protein content, adaptation to heat and drought and capacity to fix nitrogen. Europe has a deficit of cowpea production. Knowledge of genetic diversity among cowpea landraces is important for the preservation of local varieties and is the basis to obtain improved varieties. The aims of this study were to explore diversity and the genetic structure of a set of Iberian Peninsula cowpea accessions in comparison to a worldwide collection and to infer possible dispersion routes of cultivated cowpea.

9p vilarryellison 29-10-2021 21 1   Download

Whole genome re-sequencing provides powerful data for population genomic studies, allowing robust inferences of population structure, gene flow and evolutionary history. For the major malaria vector in Africa, Anopheles gambiae, other genetic aspects such as selection and adaptation are also important.

15p vilichoo2711 23-06-2021 12 1   Download

At diagnosis tumours are typically composed of a mixture of genomically distinct malignant cell populations. Bulk sequencing of tumour samples coupled with computational deconvolution can be used to identify these populations and study cancer evolution.

16p viwyoming2711 16-12-2020 9 1   Download

The knowledge of the spatial organisation of the chromatin fibre in cell nuclei helps researchers to understand the nuclear machinery that regulates DNA activity. Recent experimental techniques of the type Chromosome Conformation Capture (3C, or similar) provide high-resolution, high-throughput data consisting in the number of times any possible pair of DNA fragments is found to be in contact, in a certain population of cells.

11p vikentucky2711 24-11-2020 5 1   Download

Identifying subpopulations within a study and inferring intercontinental ancestry of the samples are important steps in genome wide association studies. Two software packages are widely used in analysis of substructure: Structure and Eigenstrat.

8p vioklahoma2711 19-11-2020 12 1   Download

Single-cell RNA sequencing is fast becoming one the standard method for gene expression measurement, providing unique insights into cellular processes. A number of methods, based on general dimensionality reduction techniques.

17p vioklahoma2711 19-11-2020 4 1   Download

Population structure inference using the software STRUCTURE has become an integral part of population genetic studies covering a broad spectrum of taxa including humans. The ever-expanding size of genetic data sets poses computational challenges for this analysis.

5p vioklahoma2711 19-11-2020 8 1   Download

Co-occurrence networks—ecological associations between sampled populations of microbial communities inferred from taxonomic composition data obtained from high-throughput sequencing techniques— are widely used in microbial ecology.

14p vijisoo2711 27-10-2020 7 0   Download

The SNP markers have emerged as essential resources for performing genetic linkage, association, and admixture studies. Both academic and commercial groups are developing large numbers of genome-wide SNP datasets. These databases are utilised for several studies involving both structural and functional genomics. Some studies viz. admixture mapping, population structure identification and quantifying genetic diversity requires a genome-wide small informative panel of relatively evenly spaced markers.

8p nguathienthan5 04-06-2020 15 0   Download

Salix caprea is a cold-tolerant pioneer species that is ecologically important in Europe and western and central Asia. However, little data is available on its population genetic structure and molecular ecology.

12p viminato2711 22-05-2020 25 1   Download

This paper sought to examine the effects of training on corporate financial performance of commercial banks. The paper was informed by the Resource-Based Theory, Human Capital Theory and Agency theory. Explanatory research design was adopted. The target population was 869 Employees from 42 commercial banks operating in Kenya according to the CBK supervisory report in 2014. 267employees were selected using Simple random sampling method. Structured questionnaire was used to collect data. Cronbach alpha was used to test Reliability, while factor analysis was used to test validity.

20p chauchaungayxua2 19-01-2020 37 2   Download

India being the agriculture based country; livestock sector becomes the backbone of the nation’s development in terms of economy and various other sectors as well. Livestock production serves as the main source of employment, income and food for over seventy percent of Indian population and women play the role of the hidden working force behind the establishment of livestock sector.

8p nguathienthan2 26-12-2019 17 0   Download

As detection of relationships improves with more samples and better methodology, families and super- families can become more populated. At present, structur- al relationships provide the highest level of classification, and structure-based databases classify proteins with similar ‘folds’. These classifications reveal that whenever structures are known for two proteins that are considered members of the same family or superfamily, the structures are similar, whereas the converse is often not true.

10p yasuyidol 02-04-2013 60 4   Download