Post translational modifications

Ovarian cancer (OC) is a complex disease with significant tumor heterogeneity with the worst prognosis and highest mortality among all gynecological cancers. Glycosylation is a specific post-translational modification that plays an important role in tumor progression, immune escape and metastatic spread. The aim of this work was to identify the major glycosylation-related genes (GRGs) in OC and construct an effective GRGs signature to predict prognosis and immunotherapy.

16p vikoch 27-06-2024 1 1   Download

Ebook "Heterologous gene expression in E. coli: Methods and protocols" herein describe methods, for example, to successfully express proteins in E. coli that would otherwise form aggregates in this host, to add post-translational modifications, to incorporate non-standard amino acid residues or moieties into E. coli expressed proteins, to identify binding partners, and to express membrane proteins.

312p dongmelo 27-05-2024 6 2   Download

Ebook "Forkhead transcription factors: Vital elements in biology and medicine" provides a unique platform for the presentation of novel work and new insights into the vital role that forkhead transcription factors play in multiple systems throughout the body. Leading international authorities provide their knowledge and insights to offer a novel perspective for translational medicine that highlights the role of forkhead genes and proteins that may have the greatest impact for the development of new strategies for a broad array of disorders.

283p ladongphongthanh1008 22-04-2024 3 2   Download

Ebook "Post-transcriptional regulation by STAR proteins: Control of RNA metabolism in development and disease" reviews the available information on the structure of the RNA binding STAR domain and provides insights into how these proteins discriminate between different RNA targets; Overviews of the post-translational modifications of STAR proteins and their effects on biological functions.

176p cotieubac1004 15-03-2024 3 0   Download

Ebook "SUMO regulation of cellular processes (Second edition)" of a very well received book that details how the sumoylation system functions and how it modulates numerous cellular activities. SUMO is a post-translational modifier in the ubiquitin super-family that has gained recognition over the last twenty years as an essential and prevalent regulatory molecule. Individual chapters explore the biochemistry, molecular biology, and cell biology of the sumoylation system and its substrate proteins.

413p cotieubac1004 15-03-2024 1 0   Download

Ebook "Protein metabolism and homeostasis in aging (Advances in experimental medicine and biology, Volume 694)" provided of the current knowledge in the area, including protein synthesis, accuracy and repair, post-translational modifications, degradation and turnover, and how they define and influence aging. The chapters mainly focus on well-characterised factors and pathways, but new areas are also presented, where associations with aging are just being elucidated by current experimental data.

268p duongthandue0501 28-02-2024 1 1   Download

Ebook "Advancements of mass spectrometry in biomedical research" explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease, and psychiatry. Additional chapters focus on methodology, technologies and instrumentation, as well as on analysis of protein-protein interactions, protein quantitation, and protein post-translational modifications. Various omics fields such as proteomics, metabolomics, glycomics, lipidomics, and adductomics are also covered.

601p nhanphanguyet 28-01-2024 2 2   Download

Ebook "Mass spectrometry: Developmental approaches to answer biological questions" is structured as follows: after a brief introduction of the usual and most popular applications for mass spectrometry in proteomics, the most recent research and developments in mass spectrometry-based methodologies will be explored. As of now, several investigations tried to improve the quantification of proteins by mass spectrometry, the determination of post-translational modifications, the protein-protein and protein-nucleic acids interaction or the proteins structures.

77p nhanphanguyet 28-01-2024 6 2   Download

Part 1 book "Milk proteins - From expression to food" includes content: The world supply of food and the role of dairy protein; milk - an overview; the comparative genomics of monotremes, marsupials, and pinnipeds - models to examine the functions of milk proteins; significance, origin, and function of bovine milk proteins - the biological implications of manipulation or modification; post translational modifications of caseins; casein micelle structure and stability; structure and stability of whey proteins; ... and other contents.

285p muasambanhan03 02-01-2024 7 2   Download

Ebook "Difference gel electrophoresis: Methods and protocols" provides a comprehensive update of this key method on gel-based proteomics. Chapters present an introduction into the development of methods on principles of differential protein labeling and two-dimensional gel electrophoresis, techniques on optimized proteomic workflows using advanced mass spectrometry for protein identification, and the application of those methods in basic biological research, pathobiology and applied biomarker discovery.

310p lucchinguyen 28-12-2023 5 2   Download

Gliomas are the most common brain tumours with the high-grade glioblastoma representing the most aggressive and lethal form. Currently, there is a lack of specific glioma biomarkers that would aid tumour subtyping and minimally invasive early diagnosis. Aberrant glycosylation is an important post-translational modification in cancer and is implicated in glioma progression.

15p vischultz 20-10-2023 1 1   Download

Part 1 book "Animal cell technology, from biopharmaceuticals to gene therapy" includes content: Introduction to animal cell technology, animal cells - basic concepts, cloning and expression of heterologous proteins in animal cells, cell metabolism and its control in culture, culture media for animal cells, post-translational modification of recombinant proteins, mechanisms of cell proliferation and cell death in animal cell culture in vitro, mathematical models for growth and product synthesis in animal cell culture.

259p oursky05 20-09-2023 6 2   Download

In this study, we conducted the sequence polymorphisms analysis in the OsHKT1;5 coding region in order to detect the potential allelic variants in some local rice cultivars in Viet Nam. In silico analysis of protein structure and post-translational modifications indicated that amino acid substitutions had no influence on protein structure but led to changes in post-translational modifications such as phosphorylation and SUMOylation.

14p vimulcahy 18-09-2023 4 3   Download

In the Western world bovine milk products are an important protein source in human diet. The major proteins in bovine milk are the four caseins (CN), αS1-, αS2-, β-, and k-CN and the two whey proteins, β-LG and α-LA. It has been shown that both the amount of specific CN and their isoforms including post-translational modifications (PTM) influence technological properties of milk.

12p vinarcissa 21-03-2023 4 1   Download

Protein glycosylation is one of the most common and critical post-translational modification, which results from covalent attachment of carbohydrates to protein backbones. Glycosylation affects the physicochemical properties of proteins and potentially their function.

10p viginny 23-12-2022 4 3   Download

The applicability of capillary zone electrophoresis (CZE) for the separation of the deamidated forms of insulin has been studied. 50 mM NH4Ac (pH=9) with 20 % v/v isopropylalcohol was found optimal for efficient separation of insulin from its even 10 deamidated forms.

8p viginny 23-12-2022 6 3   Download

Plants are advantageous as biopharmaceutical manufacturing platforms because they allow the economical and scalable upstream production of proteins, including those requiring post-translational modifications, but do not support the replication of human viruses. However, downstream processing can be more labor-intensive compared to fermenter-based systems because the product is often mixed with abundant host cell proteins.

13p viginny 23-12-2022 9 3   Download

Urothelial carcinoma (UC) is among the most prevalent malignancies. The muscle-invasive bladder cancer (MIBC) shows an invasive feature and has poor prognosis, while the non-muscle invasive bladder cancer (NMIBC) shows a better prognosis as compared with the MIBC.

16p vikolindagrabar 27-07-2022 3 1   Download

Post-translational modification plays an important role in the occurrence and development of various tumors. However, few researches were focusing on the SUMOylation regulatory genes as tumor biomarkers to predict the survival for specific patients. Here, we constructed and validated a two-gene signature to predict the overall survival (OS) of non-small cell lung cancer (NSCLC) patients.

12p visusanwojcicki 28-06-2022 9 3   Download

N-acetyltransferase 13 (NAT13) is a probable catalytic component of the ARD1A-NARG1 complex possessing alpha (N-terminal) acetyltransferase activity. Results: In this study, a full-length complementary DNA (cDNA) encoding Schistosoma japonicum NAT13 (SjNAT13) was isolated from schistosome cDNAs. The 621bp open reading frame of SjNAT13 encodes a polypeptide of 206 amino acids.

11p vidarwin 22-02-2022 16 1   Download