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Potent growth factors
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N-myc downstream-regulated gene-1 (NDRG1) is well-described as a potent metastasis suppressor, but its role in human breast cancer remains controversial and unclear. Therefore, the present study utilized a systematic review and meta-analysis approach to synthesize the association between NDRG1 protein expression and the aggressive characteristics of breast cancer.
11p
visharma
20-10-2023
4
2
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With the unprecedented rapid growth rate (up to 2.75 cm/day), velvet antler is an invaluable model for the identification of potent growth factors and signaling networks for extremely fast growing tissues, mainly cartilage.
13p
visilicon2711
20-08-2021
4
1
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Avapritinib, a potent inhibitor of KIT and platelet-derived growth factor receptor A (PDGFRA) tyrosine kinases, has demonstrated unprecedented clinical activity in PDGFRA D842V-mutant gastrointestinal stromal tumors (GIST).
9p
vianrose2711
27-04-2021
14
1
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Hence, Proper nutrient management is an important factor to be considered for sustaining pulse productivity. Among them foliar application of major nutrients like urea, DAP, KCl and Use of growth regulators are the potent force in improving the growth, flower initiation, pod setting, seed quality and yield of pulses.
6p
trinhthamhodang1215
23-09-2020
6
1
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The efficacy and safety of axitinib, a potent and selective second-generation inhibitor of vascular endothelial growth factor receptors 1, 2, and 3 in combination with pemetrexed and cisplatin was evaluated in patients with advanced non-squamous non–small-cell lung cancer (NSCLC).
10p
virose2711
24-09-2020
9
0
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Von Willebrand factor (vWF) is a potent regulator of angiogenesis, tumor growth, and metastasis. Yet, the expression pattern of vWF in human gastric cancer (GC) tissues and its relation to clinicopathological features of these cases remains unknown.
11p
vialabama2711
21-09-2020
11
1
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Axitinib is an orally active and potent tyrosine kinase inhibitor of vascular endothelial growth factor receptors 1, 2 and 3. This phase II study assessed the efficacy and safety of axitinib combined with cisplatin/gemcitabine in chemotherapy-naïve patients with advanced/metastatic (stage IIIB/IV) squamous non–small-cell lung cancer (NSCLC).
10p
vialabama2711
21-09-2020
7
0
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Overexpression or mutation of the epidermal growth factor receptor (EGFR) potently enhances the growth of many solid tumors. Tumor cells frequently display resistance to mechanistically-distinct EGFR-directed therapeutic agents, making it valuable to develop therapeutics that work by additional mechanisms.
12p
vialabama2711
21-09-2020
12
1
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Axitinib is a potent inhibitor of the vascular endothelial growth factor (VEGF) receptor family with clinical activity in patients with metastatic renal cell carcinoma (mRCC). Given this biochemical potency, the clinical activity of subsequent treatment with targeted therapies in patients progressing on axitinib is of interest.
7p
vinaypyidaw2711
26-08-2020
23
2
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Insulin-like growth factors and insulin are important factors promoting cancer growth and metastasis. The molecules act through IGF1 (IGF1R) and insulin (InsR) receptors. Rhambodmyosarcomas (RMS) overproduce IGF2 – a potent ligand for IGF1R and, at the same time, highly express IGF1 receptor.
11p
vidhaka2711
31-07-2020
8
1
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Desmoplastic small round cell tumor (DSRCT) is a rare malignant sarcoma with poor prognosis due to lack of effective treatments. Apatinib is a new potent oral small-molecule tyrosine kinase inhibitor, and targets the intracellular domain of vascular endothelial growth factor receptor 2 (VEGFR-2).
6p
vibaku2711
22-07-2020
11
1
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MAPK/ERK kinases transmit signals from many growth factors/kinase receptors during normal cell growth/differentiation, and their dysregulation is a hallmark of diverse types of cancers.
9p
vikuala271
13-06-2020
14
0
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Fibroblast growth factor 21 (FGF21) is an endocrine-acting hormone that has the potential to treat diabetic nephropathy. However, development of FGF21 into a therapeutic has been hindered due to its low intrinsic bio-stability.
11p
vihamax2711
21-04-2020
11
1
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The term plastic is given to various polymers which can be moulded in different shapes as per the requirement in different sectors. Some plastics are biodegradable while others are not. The biodegradability of plastics depends upon many factors such as polymer characteristics and growth conditions. Because of complex polymeric structure and high molecular weight microorganisms cannot degrade plastics efficiently. So, scientists discover new ways to improve biodegradation.
9p
nguaconbaynhay3
07-02-2020
10
0
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The effects of pre-treatments from s-methyl cysteine (SMC) alone, syringic acid (SA) alone and SMC plus SA against kainic acid (KA) induced injury in nerve growth factor (NGF) differentiated PC12 cells were investigated.
8p
vinasaki2711
12-11-2019
7
0
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Dendritic cells (DCs) are the most potent antigen-presenting cells (APCs) that affect prime naive T cells and create proper immune responses. The uncontrolled growth of cancer cells often results from the cell’s successful inhibition of cytotoxic T lymphocytes. In addition to conventional cancer treatments, including surgery, chemotherapy, and radiation therapy, immunotherapies have been seen to offer promising and innovative cancer treatments. Currently, DC therapy is one of the most popular immunotherapies because it uses tumour antigen-pulsed DC vaccines to fight against cancers.
5p
caygaocaolon1
13-11-2019
10
0
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The secreted glycoprotein vascular endothelial growth factor (VEGF) is a potent and specific mitogen for vascular endothelial cells, capable of stimulating angiogenesis during embryonic development and tumor formation. Despite intensive research, the functions of several VEGF family members remain a mystery.
11p
vitamix
15-02-2019
17
0
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Hepatocyte growth factor activator (HGFA) is a serine protease and a potent activator of prohepatocyte growth factor⁄scatter factor (pro-HGF⁄SF), a multifunctional growth factor that is critically involved in tis-sue morphogenesis, regeneration, and tumor progression.
15p
media19
06-03-2013
28
1
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The BCL-2 homology domain 3 (BH3)-only protein, B-cell lymphoma 2 interacting mediator of cell death (BIM) is a potent pro-apoptotic protein belonging to the B-cell lymphoma 2 protein family. In recent years, advances in basic biology have provided a clearer picture of how BIM kills cells and how BIM expression and activity are repressed by growth factor signalling pathways, especially the extracellular signal-regulated kinase 1⁄2 and protein kinase B pathways.
13p
viettel02
20-02-2013
39
1
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Hepatocyte growth factor activator (HGFA) is a serine protease initially identified as a potent activator of hepatocyte growth factor⁄scatter factor. Hepatocyte growth factor⁄scatter factor is known to be critically involved in tissue morphogenesis, regeneration, and tumor progression, via its recep-tor, MET. In vivo, HGFA also activates macrophage-stimulating protein, which has roles in macrophage recruitment and inflammatory processes, cellular survival and wound healing through its receptor, RON....
8p
mobifone23
21-01-2013
32
3
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