Pro-survival signaling

Extracellular signal regulated kinases 1 and 2 (ERK1/2) regulate cellular responses to a varietyof extracellular stimuli. In the nervous system, ERK1/2 is critical for neur-onal differentiation, plasticityand mayalso modulate neuronal survival. In this minireview, we present evidence that supports prosurvival activityof ERK1/2 in neurons. Several reports suggest that ERK1/2 mediates neuropro-tective activityof extracellular factors, including neurotro-phins. In addition, ERK1/2 is activated byneuronal injury....

6p dell39 03-04-2013 31 3   Download