Prospective cohort study

CRC with liver metastases is a major contributor to cancer-related mortality. Despite advancements in liver resection techniques, patient survival remains a concern due to high recurrence rates. This study seeks to uncover prognostic biomarkers that predict overall survival in patients undergoing curative hepatic resection for CRC liver metastases.

9p vishanshan 27-06-2024 2 1   Download

The evidence about the effects of trace elements on overall survival(OS) of patients with esophageal squamous cell carcinoma(ESCC) is limited. This study aims to evaluate mixed effects of plasma trace elements on OS of ESCC.

11p vishanshan 27-06-2024 2 1   Download

Paracetamol induces hepatotoxicity and subsequent liver injury, which may increase the risk of liver cancer, but epidemiological evidence remains unclear. We conducted this study to evaluate the association between paracetamol use and the risk of liver cancer.

8p vishanshan 27-06-2024 2 1   Download

Poor oral health has been linked to various systemic diseases, including multiple cancer types, but studies of its association with lung cancer have been inconclusive. Methods We examined the relationship between dental status and lung cancer incidence and mortality in the Golestan Cohort Study, a large, prospective cohort of 50,045 adults in northeastern Iran.

9p vikoch 27-06-2024 2 1   Download

Warfarin is the most widely used oral anticoagulant worldwide, but it has a narrow therapeutic index which necessitates constant monitoring of anticoagulation response. Previous genome-wide studies have focused on identifying factors explaining variance in stable dose, but have not explored the initial patient response to warfarin, and a wider range of clinical and biochemical factors affecting both initial and stable dosing with warfarin.

12p vioraclene 31-03-2024 9 2   Download

We examined the clinical characteristics and rates of the 12-month all-cause mortality in a cohort of patients hospitalized with acute heart failure according to heart failure duration new-onset or de novo acute heart failure and acutely decompensated chronic heart failure (ADCHF).

7p vicwell 06-03-2024 4 2   Download

Many families and individuals do not meet criteria for a known hereditary cancer syndrome but display unusual clusters of cancers. These families may carry pathogenic variants in cancer predisposition genes and be at higher risk for developing cancer.

16p vicwell 29-02-2024 4 1   Download

Large-scale trials have shown that hypofractionated adjuvant breast radiotherapy was as effective in terms of survival and local control as conventional fractionated radiotherapy, and acute toxicity was reduced with hypofractionated radiotherapy.

10p vileonardodavinci 23-12-2023 3 2   Download

No data on predicting the survival of AML patients based on the level of trace elements in the serum have been presented to date. The aims of this prospective cohort study were as follows: (i) to evaluate the serum Cu and Zn levels in people from Northeast China, (ii) to assess the association between the serum Cu level (SCL) and Cu to Zn ratio (SCZR) and clinical and nutrition data, and (iii) to investigate the predictive values of the SCL and SCZR in newly diagnosed de novo AML patients.

11p vileonardodavinci 23-12-2023 5 2   Download

Traditional observational studies have shown an inverse association between body mass index (BMI) and lung cancer risk. Mendelian randomization (MR) analysis using genetic variants as instruments for BMI may clarify the nature of the association. We studied the causal association between BMI and lung cancer incidence using observational and MR approaches.

10p vileonardodavinci 23-12-2023 10 4   Download

The aim of this prospective study was to investigate the prognostic value of metabolic tumor volume (MTV) and apparent diffusion coefficient (ADC) from baseline FDG PET/MRI compared to established clinical risk factors in terms of progression-free survival (PFS) at 2 years in a cohort of diffuse large B-cell Lymphoma (DLBCL) and high-grade-B-cell lymphoma (HGBCL).

9p vileonardodavinci 23-12-2023 5 4   Download

The pathological diagnosis and prognosis prediction of hepatocellular carcinoma (HCC) is challenging due to the lack of specific biomarkers. This study aimed to validate the diagnostic and prognostic efficiency of Kidney-type glutaminase (GLS1) for HCC in prospective cohorts with a large sample size.

12p vileonardodavinci 23-12-2023 4 3   Download

Protocol of the Comparison of Intravesical Therapy and Surgery as Treatment Options (CISTO) study: A pragmatic, prospective multicenter observational cohort study of recurrent high-grade non-muscle invasive bladder cancer

12p vileonardodavinci 23-12-2023 2 2   Download

Methylation levels may be associated with and serve as markers to predict risk of progression of precancerous cervical lesions. We conducted an epigenome-wide association study (EWAS) of CpG methylation and progression to high-grade cervical intraepithelial neoplasia (CIN2+) following an abnormal screening test.

14p vialfrednobel 23-12-2023 5 3   Download

Current chemotherapy-induced peripheral neuropathy (CIPN) assessment tools mostly have poor sensitivity and weak anti-interference, so that it is sometimes difficult to provide substantive guidance for clinical intervention. This study aimed to develop an assessment tool dedicated for oxaliplatin to address these limitations.

12p vialfrednobel 23-12-2023 3 3   Download

To assess the feasibility, safe, effectiveness of laparoscopic lateral pelvic lymph node dissection (LPLD) for treatment in low rectal cancer. Subject and method: This was a prospective cohort study of rectal cancers for multidisciplinary treatment with LPLD at Department of Colon and Rectal Surgery, 108 Military Central Hospital between July 2018 and July 2019.

7p visoros 01-11-2023 3 1   Download

Diet, alcohol, cigarette smoking, physical inactivity, and body mass index have been studied as risk factors for renal cell cancer (RCC). The joint effects of these lifestyle factors, captured as Healthy Lifestyle Index (HLI), were examined in one previous study. This study aims to investigate the association between HLI score and RCC risk in the prospective Netherlands Cohort Study (NLCS).

12p vischultz 20-10-2023 5 1   Download

Neoadjuvant chemoradiotherapy (nCRT) followed by esophagectomy is a standard treatment for potentially curable esophageal cancer. Active surveillance in patients with a clinically complete response (cCR) 12 weeks after nCRT is regarded as possible alternative to standard surgery. The aim of this study is to monitor the safety, adherence and effectiveness of active surveillance in patients outside a randomized trial.

10p vischultz 20-10-2023 4 1   Download

The Neo-REGATTA study evaluated the effectiveness and safety of Docetaxel, oxaliplatin, and S-1 (DOS regimen) followed by radical resection vs. chemotherapy in advanced gastric adenocarcinoma patients with single non-curable factor.

8p vischultz 20-10-2023 2 1   Download

This study aimed to investigate the effect of preoperative albumin-to-globulin ratio (AGR) on overall survival (OS) and health-related quality of life in patients with esophageal cell squamous carcinoma (ESCC).

9p vischultz 20-10-2023 4 1   Download