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Protein classification
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Ebook "Heat shock proteins in neural cells" address the role of heat shock proteins and cellular stress responses in the brain, with a major focus on nerve cells and glia, namely oligodendrocytes and astrocytes. Chapter 1 summarizes the classification and functional roles of heat shock proteins which are particularly abundant in brain cells.
123p
tracanhphuonghoa1007
22-04-2024
1
1
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Classification of rare missense variants remains an ongoing challenge in genomic medicine. Evidence of pathogenicity is often sparse, and decisions about how to weigh different evidence classes may be subjective.
12p
vicwell
29-02-2024
9
2
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Part 2 book "Textbook of biochemistry - With clinical correlations" includes content: Proteins II - Structure function relationships in protein familie; enzymes - Classification, kinetics, and control; the cytochromes p450 and nitric oxide synthases; biological membranes - structure, receptors, and solute transport; fundamentals of signal transduction; bioenergetics, mitochondria, and oxidative metabolism,... and other contents.
374p
muasambanhan04
07-01-2024
3
1
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Gliomas are the most common malignant brain tumors, with powerful invasiveness and an undesirable prognosis. Actin-related protein 2/3 complex subunit 5 (ARPC5) encodes a component of the Arp2/3 protein complex, which plays a significant role in regulating the actin cytoskeleton.
14p
visharma
20-10-2023
2
2
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Protein classification is a task of paramount importance in various fields of biology. Despite the great momentum of modern implementation of protein classification, machine learning techniques such as Random Forest and Neural Network could not always be used for several reasons: Data collection, unbalanced classification or labelling of the data.
18p
vihagrid
30-01-2023
5
3
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Crosslinking immunoprecipitation sequencing (CLIP-seq) technologies have enabled researchers to characterize transcriptome-wide binding sites of RNA-binding protein (RBP) with high resolution. We apply a soft-clustering method, RBPgroup, to various CLIP-seq datasets to group together RBPs that specifically bind the same RNA sites.
16p
vialfrednobel
29-01-2022
15
0
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Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. The strength of these methods makes them particularly useful for next-generation sequencing data processing and analysis.
17p
vialfrednobel
29-01-2022
12
0
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The diversity of processed transcripts in eukaryotic genomes poses a challenge for the classification of their biological functions. Sparse sequence conservation in non-coding sequences and the unreliable nature of RNA structure predictions further exacerbate this conundrum.
12p
vialfrednobel
29-01-2022
4
0
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Ranking human genes based on their tolerance to functional genetic variation can greatly facilitate patient genome interpretation. It is well established, however, that different parts of proteins can have different functions, suggesting that it will ultimately be more informative to focus attention on functionally distinct portions of genes. Here we evaluate the intolerance of genic sub-regions using two biological sub-region classifications.
11p
viaristotle
29-01-2022
10
0
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The physiological role of lectins in a plant is still not well understood. The overabundant presence of lectins in plant seeds and storage tissues indicated their role in plant development. Plant lectins shows a broad range of activities like antibacterial, antifungal, insecticidal, anticancerous, antileishmanial, antiviral, and anticoagulants. In this review, we aim to highlight the plant lectins classification and their application in various biological aspects.
10p
mudbound
10-12-2021
12
1
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Cholangiocarcinoma (CCA) is an aggressive disease with poor prognosis. A molecular classification based on mutational, methylation and transcriptomic features could allow identifying tailored therapies to improve CCA patient outcome. Proteomic remains partially unexplored.
11p
vimahuateng
26-11-2021
10
1
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The results showed that fabp10a gene was not strongly expressed in all 3 types of tissues; fabp3 gene was most strongly expressed in liver tissue and fabp7 was highly up-regulated in brain tissue. The results of this study provide a resource for further research on the function of fabp genes and their genetic diversity in striped catfish.
12p
spiritedaway36
25-11-2021
7
1
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The ability to predict the interaction of drugs with target proteins is essential to research and development of drug. However, the traditional experimental paradigm is costly, and previous in silico prediction paradigms have been impeded by the wide range of data platforms and data scarcity.
10p
vitzuyu2711
29-09-2021
11
1
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Proteins are a kind of macromolecules and the main component of a cell, and thus it is the most essential and versatile material of life. The research of protein functions is of great significance in decoding the secret of life. In recent years, researchers have introduced multi-label supervised topic model such as Labeled Latent Dirichlet Allocation (Labeled-LDA) into protein function prediction, which can obtain more accurate and explanatory prediction.
14p
viseulgi2711
31-08-2021
8
1
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Controlled turnover of proteins as mediated by the ubiquitin proteasome system (UPS) is an important element in plant defense against environmental and pathogen stresses. E3 ligases play a central role in subjecting proteins to hydrolysis by the UPS.
15p
visilicon2711
20-08-2021
9
1
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Adaptor proteins are carrier proteins that play a crucial role in signal transduction. They commonly consist of several modular domains, each having its own binding activity and operating by forming complexes with other intracellular-signaling molecules. Many studies determined that the adaptor proteins had been implicated in a variety of human diseases.
9p
viansan2711
30-07-2021
9
1
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We performed an in-depth analysis of the ABC gene family in Aedes aegypti (Diptera: Culicidae), which is an important vector species of arthropod-borne viral infections such as chikungunya, dengue, and Zika. Despite its importance, previous studies of the Arthropod ABC family have not focused on this species.
10p
vijeeni2711
24-07-2021
8
0
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Aquaporins (AQPs), as members of the major intrinsic protein (MIP) superfamily, facilitated the permeation of water and other solutes and are involved in multiple biological processes. AQP family exists in almost all living organisms and is highly diversified in vertebrates in both classification and function due to genome wide duplication.
20p
vijeeni2711
30-06-2021
9
1
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Protein kinases (PKs) play an important role in signaling cascades and are one of the largest and most conserved protein super families in plants. Despite their importance, the woodland strawberry (Fragaria vesca) kinome and expression patterns of PK genes remain to be characterized.
14p
vijeeni2711
30-06-2021
14
1
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With the development of third-generation sequencing (TGS) technologies, people are able to obtain DNA sequences with lengths from 10s to 100s of kb. These long reads allow protein domain annotation without assembly, thus can produce important insights into the biological functions of the underlying data.
13p
vilichoo2711
23-06-2021
13
1
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