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Recombinant adenovirus
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Melanoma differentiation-associated gene 7 (Mda-7) encodes IL-24, which can induce apoptosis in cancer cells. A novel gene therapy approach to treat deadly brain tumors, recombinant mda-7 adenovirus (Ad/ mda-7) efficiently kills glioma cells. In this study, we investigated the factors affecting cell survival and apoptosis and autophagy mechanisms that destroy glioma cells by Ad/IL-24.
13p
visharma
20-10-2023
7
2
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Part 2 book "Transgenic mouse, methods and protocols" includes content: Engineering BAC reporter gene constructs for mouse transgenesis; targeting vector construction through recombineering, generating conditional knockout mice, hypomorphic mice, knock in approaches, selection of targeted mutants from a library of randomly mutagenized ES cells,...and other contents.
190p
oursky05
20-09-2023
1
1
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Vesicular stomatitis (VS) is an acute, highly contagious and economically important zoonotic disease caused by the vesicular stomatitis virus (VSV). There is a need for effective and safe stable recombinant vaccine for the control of the disease. The human type 5 replication-defective adenovirus expression vector is a good way to construct recombinant vaccines.
9p
vidarwin
23-02-2022
7
1
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The aim of this study was to determine the clinical benefit of transhepatic arterial chemoembolization (TACE) with or without recombinant human adenovirus type 5 (H101) administration for the treatment of patients with hepatocellular carcinoma (HCC).
9p
vimoscow2711
29-08-2020
10
1
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The fowl adenoviruses have been studied extensively because of their involvement in many pathogenic conditions of poultry and considerable interest to use as gene delivery vehicles. The major structural proteins of virion include hexons and pentons (penton base and fiber). Among these proteins, only hexons have been characterized extensively at molecular level. The present study was conducted for molecular characterization of penton base gene.
10p
angicungduoc6
22-07-2020
7
2
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Colorectal cancer (CRC) is the most common type of gastrointestinal cancer. CRC gene therapy mediated by adenovirus holds great promise for the treatment of malignancies. However, intravenous delivery of adenovirus exhibits limited anti-tumor activity in vivo when used alone.
10p
vimanila2711
25-06-2020
13
1
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BMPs play important roles in regulating stem cell proliferation and differentiation. Using adenovirus-mediated expression of the 14 types of BMPs we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of mesenchymal stem cells (MSCs), which was undetected in the early studies using recombinant BMP9 proteins.
11p
viwashington2711
04-12-2019
4
1
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To evaluate the safety of recombinant adenovirus coding the human IL-12 protein in mice. Subjects and methods: BALB/c mice were divided into 3 groups, each group of 9 mice, including control group, recombinant adenovirus coding the human IL-12 protein injection group at 106 vp/head, recombinant adenovirus coding the human IL-12 protein injection group at 107 vp/head. Mice were monitored for general health, liver and kidney function, and tested for the presence of recombinant adenovirus coding the human IL-12 protein in mouse organs.
6p
chauchaungayxua1
02-12-2019
4
0
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To evaluate the safety of recombinant adenovirus coding the human IL-12 protein in mice. Subjects and methods: BALB/c mice were divided into 3 groups, each group of 9 mice, including control group, recombinant adenovirus coding the human IL-12 protein injection group at 106 vp/head, recombinant adenovirus coding the human IL-12 protein injection group at 107 vp/head.
6p
viwashington2711
03-12-2019
10
0
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Perfluorochemical (PFC) liquid enhances recombinant adenovirus vector-mediated viral interleukin-10 (AdvIL-10) expression in rodent lung...
7p
thulanh27
13-12-2011
41
2
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Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Organ distribution of transgene expression following intranasal mucosal delivery of recombinant replication-defective adenovirus gene transfer vector
0p
toshiba20
12-11-2011
39
1
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Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Effects of recombinant adenovirus-mediated expression of IL-2 and IL-12 in human B lymphoma cells on co-cultured PBMC
0p
toshiba20
12-11-2011
45
2
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