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Recombinant protein therapeutics
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Part 2 book "Animal cell technology, from biopharmaceuticals to gene therapy" includes content: Bioreactors for animal cells, monitoring and control of cell cultures, animal cell separation, product purification processes, quality control of biotechnological products, regulatory aspects, intellectual property, recombinant therapeutic proteins, monoclonal antibodies, viral vaccines - concepts, principles, and bioprocesses, bioinsecticides, cell therapies and stem cells, gene therapy.
306p
oursky05
20-09-2023
6
2
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The majority of autoimmune and allergic diseases are associated with abnormal expression of interleukin (IL)-33, a member of the IL-1 family of cytokines, that function dually as a proinflammatory cytokine and a transcriptional factor.
16p
vimulcahy
18-09-2023
4
3
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Due to the degeneracy of the genetic code, most amino acids can be encoded by multiple synonymous codons. Synonymous codons naturally occur with different frequencies in different organisms. The choice of codons may affect protein expression, structure, and function.
10p
viflorida2711
30-10-2020
13
2
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Relatively poor penetration and retention in tumor tissue has been documented for large molecule drugs including therapeutic antibodies and recombinant immunoglobulin constant region (Fc)-fusion proteins due to their large size, positive charge, and strong target binding affinity.
14p
vialabama2711
21-09-2020
10
0
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The exploitation of the surface display system of food and commensal lactic acid bacteria (LAB) for bacterial, viral, or protozoan antigen delivery has received strong interest recently. The Generally Regarded as Safe (GRAS) status of the Lactococcus lactis coupled with a non-recombinant strategy of in-trans surface display, provide a safe platform for therapeutic drug and vaccine development.
10p
viuchiha2711
21-04-2020
11
1
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Recombinant cell lines developed for therapeutic antibody production often suffer instability or lose recombinant protein expression during long-term culture. Heterogeneous gene expression among cell line subclones may result from epigenetic modifications of DNA or histones, the protein component of chromatin.
16p
viuchiha2711
21-04-2020
14
0
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Recombinant proteins of therapeutic use are ideally produced in human cells to ensure appropriate co- and post-translational modifications. However, purification of secreted proteins from the culture media is impeded by low expression from transfected cell lines and the presence of serum proteins.
11p
viuchiha2711
21-04-2020
15
0
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Recombinant factor VIII (FVIII), used for haemophilia A therapy, is one of the most challenging among the therapeutic proteins produced in heterologous expression systems. Deletion variant of FVIII, in which the entire domain B is replaced by a short linker peptide, was approved for medical use.
15p
vihamax2711
21-04-2020
17
2
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Preclinical studies have evaluated haptoglobin (Hp) polymers from pooled human plasma as a therapeutic protein to attenuate toxic effects of cell-free hemoglobin (Hb). Proof of concept studies have demonstrated efficacy of Hp in hemolysis associated with transfusion and sickle cell anemia.
13p
vihamax2711
21-04-2020
13
1
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Filgrastim or methionyl-granulocyte colony-stimulating factor (Met-G-CSF), is a recombinant therapeutic protein widely used to treat severe neutropenia caused by myelosuppressive drugs in patients with nonmyeloid malignancies.
13p
vienzym2711
03-04-2020
7
2
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The main aim of this study is to critically investigate in current up-to-date the technology of rDNA and its biomedical applications as therapeutic proteins. rDNA is the new technology and is a field of molecular biology where scientist reshape the DNA to form synthetic molecular that help to cure many diseases related to human being. A therapeutic proteins are proteins engineered in laboratory for pharmaceutical purpose, making of insulin is one of the most important benefits ever could be achieved by this technology.
9p
nguaconbaynhay3
07-02-2020
8
0
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(bq) part 1 book “update on production of recombinant therapeutic protein - transient gene expression” has content: transient gene expression in different expression systems, recent advances in transient gene expression protocol.
91p
dien_vi09
21-10-2018
36
3
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(bq) part 2 book “update on production of recombinant therapeutic protein - transient gene expression” has content: optimisation of transient gene expression for therapeutic protein production, clinical applications of the transient gene expression.
97p
dien_vi09
21-10-2018
38
1
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Pseudomonasexotoxin A (PE) is a highly toxic protein secreted by the opportunistic pathogen Pseudomonas aeruginosa. The modular structure and corresponding mechanism of action of PE make it amenable to exten-sive modifications that can redirect its potent cytotoxicity from disease to a therapeutic function.
18p
cosis54
04-01-2013
35
2
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Since the introduction of recombinant human growth hormone and insulin a quarter century ago, protein therapeutics has greatly broadened the horizon of health care. Many patients suffering with life-threatening diseases or chronic dysfunctions,whichweremedically untreatable not long ago, can attest to the wonder these drugs have achieved. Although the first generation of protein therapeutics was produced in recombinant Escherichia coli, most recent products usemammalian cells as production hosts.Not long after the first production of recombinant proteins in E.
179p
codoc_pn87
24-11-2012
59
10
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Twenty-five years ago, Georges Köhler and César Milstein invented a means of cloning individual antibodies, thus opening up the way for tremendous advances in the fields of cell biology and clinical diagnostics (1). However, in spite of their early promise, monoclonal antibodies (MAbs) were largely unsuccessful as therapeutic reagents resulting from insufficient activation of human effector functions and immune reactions against proteins of murine origin.
456p
tom_123
15-11-2012
78
9
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