Resistant gram negative pathogens
-
The recent emergence and dissemination of high-level mobile tigecycline resistance Tet(X) challenge the clinical effectiveness of tigecycline, one of the last-resort therapeutic options for complicated infections caused by multidrug-resistant Gram-negative and Gram-positive pathogens.
13p vibransone 28-03-2024 4 2 Download
-
Klebsiella pneumoniae is a gram-negative bacterial species capable of occupying a broad range of environmental and clinical habitats. Known as an opportunistic pathogen, it has recently become a major causative agent of clinical infections worldwide.
10p vioraclene 31-03-2024 6 2 Download
-
Elizabethkingia meningoseptica is an uncommon pathogen that has been associated with nosocomial infections and can pose a therapeutic challenge. It is resistant to most conventional agents used in treatment of gram-negative organisms and as such use of these agents may be unfavorable.
3p viintuit 26-09-2023 1 0 Download
-
M. morganii is a gram-negative, non-lactose fermenting and an opportunistic pathogen frequently associated with nosocomial infections. Although first isolated in 1906 from a pediatric fecal sample, not many M. morganii isolates have been sequenced.
3p vihagrid 30-01-2023 5 3 Download
-
Detection of bacteria using antimicrobial polymer derived via ring-opening metathesis (romp) pathway
There is growing interest in the detection of bacteria in consumables, for example, in the food and water sectors. In this study, the aim was to produce a polymer-based bacteria biosensor via ROMP (ring opening metathesis polymerization). In the first part of the study, block and random copolymers were synthesized, and their biocidal activities were tested on the glass surface. Interdigitated electrode arrays coated with the polymers possessing the highest activity were used to screen the affinity towards different bacterial strains by monitoring impedance variations in real-time.
37p tudichquannguyet 29-11-2021 8 1 Download
-
Pseudomonas putida is a Gram-negative, non-fermenting bacterium frequently encountered in various environmental niches. P. putida rarely causes disease in humans, though serious infections and outbreaks have been reported from time to time. Some have suggested that P. putida functions as an exchange platform for antibiotic resistance genes (ARG), and thus represents a serious concern in the spread of ARGs to more pathogenic organisms within a hospital.
11p vilarryellison 29-10-2021 9 0 Download
-
Pandoraea species are considered emerging pathogens in the context of cystic fibrosis (CF) and are difficult to identify by conventional biochemical methods. These multidrug resistant bacteria remain poorly understood particularly in terms of natural resistance, mechanisms of acquired resistance and impact on the prognosis of the disease and the lung function.
5p vimaine2711 26-03-2021 14 2 Download
-
Gram negative pathogens acts as a significant etiological agent in causing both hospital and community acquired infections for the past few decades. Various resistance mechanisms, especially β-lactamases triggered extensive use of β-lactams. Carbapenems stands as the last resort to save many life threatening diseases. To prevent extensive Carbapenemases dissemination, this study was aimed to know the in vitro susceptibility pattern of Cefepime/tazobactam with carbapenems and other BL/BLI combinations.
7p gaocaolon9 22-12-2020 15 1 Download
-
Acquired resistance to carbapenems mediated by carbapenemases in gram-negative pathogens such as Escherichia coli and Klebsiella has become worldwide. Its detection is of utmost importance in deciding the most appropriate therapeutic regimen and for this we require a simple and inexpensive testing method. A total of 250 isolates which included Escherichia coli (113) and Klebsiella spp (137) were screened for meropenem resistance by Kirby-Bauer disc diffusion method.
8p gaocaolon9 22-12-2020 15 2 Download
-
The main aim of this study includes, to isolate and speciate the Klebsiella isolates from various clinical specimens from patients admitted in ICU. To determine the antibiotic susceptibility pattern of Klebsiella species by disc diffusion method. And to detect the presence of extended spectrum betalactamases (ESBL) by double disc synergy test and Inhibitor Potentiated disc diffusion test.
22p dayhoctainha 10-09-2020 25 1 Download
-
Non-fermenting gram negative bacilli (NFGNB) are a group of aerobic, non spore forming bacilli. They either do not use carbohydrates as a source of energy or degrade them through metabolic pathways other than fermentation. They are ubiquitous in nature. Although they are commonly considered to be environmental contaminants, they have emerged as important nosocomial pathogens. Aim of this study was to characterize the prevalence of NFGNB distribution from various clinical isolates and to evaluate their antibiotic sensitivity patterns.
8p trinhthamhodang7 31-08-2020 10 1 Download
-
Neonatal septicemia is responsible for nearly half of neonatal deaths. With emerging drug resistance mechanisms like Metallo Beta lactamase (MBL) production, treatment of neonatal sepsis has become a challenge. The present study was done to identify prevalence of bacterial pathogens, their resistance profile and incidence of MBL mediated resistance among Gram negative bacterial isolates in neonatal sepsis. Seventy three cases of suspected neonatal septicemia were included in this prospective study. Blood culture was done by BacT/Alert 3D system, bacterial isolates were identified.
7p angicungduoc6 20-07-2020 10 1 Download
-
To isolate the bacterial pathogens causing asymptomatic bacteriuria in antenatal women,to study the drug resistance pattern and prevalence of MRSA and ESBL producers. Bacterial pathogens were isolated from 1000 urine samples collected from antenatal women following standard procedures. All the isolates were studied for antibiotic susceptibility pattern using modified Kirby bauer disc diffusion method. Resistant isolates were identified and studied for MRSA and ESBL by various methods. Out of 1000 urine samples culture positive were 118(11.8%). E.
9p nguaconbaynhay6 23-06-2020 18 1 Download
-
About 150 million people suffer from urinary tract infection each year. In majority of cases, treatment is initiated empirically based on the antimicrobial resistance pattern of the urinary pathogens prevalent in a particular setting. Emerging antibiotic resistance among Enterobacteriaceae has posed challenges in choosing empiric regimens. Therefore, the present study was designed to identify etiological agents of urinary tract infections, detect ESBL producing uropathogens and study their antibiotic resistance profile.
11p trinhthamhodang1213 30-05-2020 16 0 Download
-
Global prevalence of infectious diseases caused by microorganism is a major public health problem. Resistance against antibiotics of abundant bacteria is gradually acquiring. Therefore, investigation for new inventive plant materials with antimicrobial activity has become an insistent necessity.
9p trinhthamhodang5 16-05-2020 17 2 Download
-
Non fermenting Gram Negative Bacilli (NFGNB) once considered as contaminants, now emerged as a major cause of life threatening nosocomial infections and as multidrug resistant pathogens. Acinetobacter species are the opportunistic pathogens with increasing prevalance in the nosocomial infections. Community acquired infections are also common in Acinetobacter. It accounts for 10% of all community-acquired bacteremic pneumonias. To isolate, identify and detect Carbapenem resistance producing Acinetobacter spp., and confirm Metallo Beta Lactamase ( MBL) production by phenotypic methods.
10p trinhthamhodang5 16-05-2020 15 1 Download
-
Urinary tract infection (UTI) is considered as the most common bacterial infectious disease seen among the pediatric patients. Pediatric urinary tract infections are associated with high morbidity and long term complications like renal scaring, hypertension and chronic renal failure The epidemiology of UTI during childhood varies by age, gender and other factors (Bickerton and Ducket, 1985). Most commonly bacteria causes of UTI in children are members of Enterobacteriaceae, particularly uropathogenic strains of E. coli and Klebsiella spp.
11p nguaconbaynhay5 11-05-2020 20 1 Download
-
Stenotrophomonas maltophilia is increasingly being isolated as a nosocomial pathogen. It is the third most common non-fermenting gram negative bacilli (NFGNB) isolated from the clinical samples especially from the respiratory specimens, blood, urine and pus samples. Though inherently resistant to many groups of antibiotics, its susceptibility to co-trimoxazole is a peculiar character, because of which Co-trimoxazole is considered as the drug of choice for treating these infections.
6p cothumenhmong4 25-03-2020 14 0 Download
-
Blood stream infections (BSI) are a global burden in developing countries. Increased incidence leads to morbidity and mortality in neonates as well as Paediatric age group patients. Blood culture is an effective tool for diagnosis of BSI. Aim is to determine various blood stream pathogens and their antibiotic susceptibility pattern.
11p chauchaungayxua4 22-03-2020 19 1 Download
-
Pseudomonas aeruginosa and Acinetobacter baumanii are aerobic non fermenting gram negative opportunistic pathogens that are major causes of nosocomial infections. Both these microorganisms thrive well in nutrient-deprived conditions and are responsible for a wide spectrum of infections. They show a higher predilection for infection in patients with diminished host defenses. Intensive care units are considered the epicenter of antibiotic resistant infections.
9p chauchaungayxua4 18-03-2020 13 0 Download