Response phenotypes

Xem 1-16 trên 16 kết quả Response phenotypes

Percent change in apparent difusion coefcient and plasma EBV DNA after induction chemotherapy identifies distinct prognostic response phenotypes in advanced nasopharyngeal carcinoma

To evaluate the prognostic value of the apparent diffusion coefficient (ADC) derived from difusionweighted magnetic resonance imaging (MRI) and monitor the early treatment response to induction chemotherapy (IC) with plasma EBV DNA in locoregionally advanced nasopharyngeal carcinoma (LA-NPC).

9p vielonmusk 21-01-2022 12 1 Download

High efficacy of PD-1 inhibitor after initial failure of PD-L1 inhibitor in Relapsed/Refractory classical Hodgkin Lymphoma

$High efficacy of PD-1 inhibitor after initial failure of PD-L1 inhibitor in Relapsed/Refractory classical Hodgkin Lymphoma$

We sought to understand the clinical course and molecular phenotype of patients who showed disease progression after programmed cell death ligand 1 (PD-L1) inhibitor treatment but subsequently responded to PD-1 inhibitor treatment. We also explored the response to PD-1-axis targeted therapy of classical Hodgkin lymphoma (cHL) according to genetically driven PD-L1 and programmed cell death ligand 2 (PD-L2) expression.

8p vielonmusk 21-01-2022 15 1 Download

Regulator of G protein signaling 17 as a negative modulator of GPCR signaling in multiple human cancers

Regulators of G protein signaling (RGS) proteins modulate G protein-coupled receptor (GPCR) signaling networks by terminating signals produced by active Gα subunits. RGS17, a member of the RZ subfamily of RGS proteins, is typically only expressed in appreciable amounts in the human central nervous system, but previous works have shown that RGS17 expression is selectively upregulated in a number of malignancies, including lung, breast, prostate, and hepatocellular carcinoma.

10p caothientrangnguyen 09-05-2020 12 0 Download
Báo cáo khoa học: Expression proﬁling reveals differences in metabolic gene expression between exercise-induced cardiac effects and maladaptive cardiac hypertrophy

While cardiac hypertrophy elicited by pathological stimuli eventually leads to cardiac dysfunction, exercise-induced hypertrophy does not. This sug-gests that a beneficial hypertrophic phenotype exists. In search of an under-lying molecular substrate we used microarray technology to identify cardiac gene expression in response to exercise. Rats exercised for seven weeks on a treadmill were characterized by invasive blood pressure mea-surements and echocardiography.

12p awards 06-04-2013 35 3 Download
Báo cáo khóa học: A single mutation that causes phosphatidylglycerol deﬁciency impairs synthesis of photosystem II cores in Chlamydomonas reinhardtii

Two mutants ofChlamydomonas reinhardtii, mf1andmf2, characterized by a marked reduction in their phosphatidyl-glycerol content together with a complete loss in itsD 3 -trans hexadecenoic acid-containing form, also lost photosystemII (PSII) activity. Genetic analysis of crosses betweenmf2and wild-type strains shows a strict cosegregationof thePSII and lipid deficiencies, while phenotypic analysis of phototrophic revertant strains suggests that one single nuclear mutation is responsible for the pleiotropic phenotype of the mutants....

10p dell39 03-04-2013 51 3 Download
Báo cáo khoa học: Dissecting the role of the N-terminal metal-binding domains in activating the yeast copper ATPase in vivo

In yeast, copper delivery to the trans-Golgi network involves interactions between the metallo-chaperone Atx1 and the N-terminus of Ccc2, the P-type ATPase responsible for copper transport acrosstrans-Golgi network membranes. Disruption of the Atx1–Ccc2 route leads to cell growth arrest in a copper-and-iron-limited medium, a phenotype allowing complementa-tion studies.

13p vinaphone15 25-02-2013 44 5 Download
Báo cáo hóa học: "Comparison of anti-CD3 and anti-CD28-coated beads with soluble anti-CD3 for expanding human T cells: Differing impact on CD8 T cell phenotype and responsiveness to restimulation"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Comparison of anti-CD3 and anti-CD28-coated beads with soluble anti-CD3 for expanding human T cells: Differing impact on CD8 T cell phenotype and responsiveness to restimulation

15p dauphong4 03-01-2012 51 5 Download
báo cáo khoa học: " A strong constitutive ethylene-response phenotype conferred on Arabidopsis plants containing null mutations in the ethylene receptors ETR1 and ERS1"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A strong constitutive ethylene-response phenotype conferred on Arabidopsis plants containing null mutations in the ethylene receptors ETR1 and ERS1

15p panasonic06 26-12-2011 58 5 Download
Antinociceptive effects of morphine and naloxone in mu-opioid receptor knockout mice transfected with the MORS196A gene

Opioid analgesics such as morphine and meperidine have been used to control moderate to severe pain for many years. However, these opioids have many side effects, including the development of tolerance and dependence after long-term use, which has limited their clinical use. We previously reported that mutations in the muopioid receptors (MOR) S196L and S196A rendered them responsive to the opioid antagonist naloxone without altering the agonist phenotype. In MORS196A knock-in mice, naloxone and naltrexone were antinociceptive but did not cause tolerance or physical dependence.

6p toshiba23 18-11-2011 50 1 Download
Báo cáo y học: "Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype...

0p thulanh20 12-11-2011 55 2 Download
Báo cáo y học: "Systematic profiling of cellular phenotypes with spotted cell microarrays reveals mating-pheromone response genes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Systematic profiling of cellular phenotypes with spotted cell microarrays reveals mating-pheromone response genes...

9p thulanh20 10-11-2011 28 4 Download
Báo cáo sinh học: "Phenotypic plasticity of body pigmentation in Drosophila: Inferences about variance components and selection response for body weight in chicken"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh Original cung cấp cho các bạn kiến thức về sinh học đề tài:Phenotypic plasticity of body pigmentation in Drosophila: Inferences about variance components and selection response for body weight in chickens...

13p toshiba19 09-11-2011 52 6 Download
Báo cáo y học: "integrating phenotypic and expression profiles to map arsenic-response"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: integrating phenotypic and expression profiles to map arsenic-response...

18p thulanh19 09-11-2011 41 3 Download
Báo cáo y học: "Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaste"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster...

15p coxanh_8 05-11-2011 44 2 Download
Báo cáo y học: "Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression...

13p thulanh14 19-10-2011 44 3 Download
Chapter 086. Breast Cancer (Part 10)

Endocrine Therapy Normal breast tissue is estrogen-dependent. Both primary and metastatic breast cancer may retain this phenotype. The best means of ascertaining whether a breast cancer is hormone-dependent is through analysis of estrogen and progesterone receptor levels on the tumor. Tumors that are positive for the estrogen receptor and negative for the progesterone receptor have a response rate of ~30%. Tumors that have both receptors have a response rate approaching 70%. If neither receptor is present, the objective response rates are ...

5p konheokonmummim 03-12-2010 82 4 Download