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RNA modification
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The incidence of prostate cancer (PCa), the most prevalent malignancy, is currently at the forefront. RNA modification is a subfield of the booming field of epigenetics. To date, more than 170 types of RNA modifications have been described, and N6-methyladenosine (m6A) is the most abundant and well-characterized internal modification of mRNAs involved in various aspects of cancer progression.
16p
vishanshan
27-06-2024
1
1
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Ovarian cancer (OC) is a complex disease with significant tumor heterogeneity with the worst prognosis and highest mortality among all gynecological cancers. Glycosylation is a specific post-translational modification that plays an important role in tumor progression, immune escape and metastatic spread. The aim of this work was to identify the major glycosylation-related genes (GRGs) in OC and construct an effective GRGs signature to predict prognosis and immunotherapy.
16p
vikoch
27-06-2024
1
1
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Accumulating evidence suggests alternative splicing (AS) is a co-transcriptional splicing process not only controlled by RNA-binding splicing factors, but also mediated by epigenetic regulators, such as chromatin structure, nucleosome density, and histone modification. Aberrant AS plays an important role in regulating various diseases, including cancers.
11p
vibransone
28-03-2024
5
2
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Genome-wide association studies have identified over 160 loci that are associated with coronary artery disease. As with other complex human diseases, risk in coronary disease loci is determined primarily by altered expression of the causal gene, due to variation in binding of transcription factors and chromatin-modifying proteins that directly regulate the transcriptional apparatus.
18p
vibransone
28-03-2024
4
1
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Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals express a mutant version of the nuclear envelope protein lamin A (termed progerin) and have previously been shown to exhibit prominent histone modification changes.
16p
vibransone
28-03-2024
3
2
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Ebook "Post-transcriptional regulation by STAR proteins: Control of RNA metabolism in development and disease" reviews the available information on the structure of the RNA binding STAR domain and provides insights into how these proteins discriminate between different RNA targets; Overviews of the post-translational modifications of STAR proteins and their effects on biological functions.
176p
cotieubac1004
15-03-2024
3
0
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Part 1 book "Textbook of biochemistry - With clinical correlations" includes content: Eukaryotic cell structure; DNA and RNA - Composition and structure; DNA and RNA - Composition and structure; DNA replication, recombination, and repair; RNA - Transcription and RNA processing; protein synthesis - Translation and posnranslational modifications; recombinant DNA and biotechnology; regulation of gene expression.
368p
muasambanhan04
07-01-2024
3
1
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LncRNA N6-methylandenosine (m6A) modification has been shown to be associated with the constitution of the tumor microenvironment (TME) and tumorigenesis. It’s essential to understand the mechanisms of lncRNA m6A modification in hepatocellular carcinoma (HCC) and identify relative prognostic predictors to guide therapy and explore potential therapeutic targets. Pearson correlation analysis was performed to identify m6A-related lncRNAs in 374 patients with HCC.
18p
vimichaelfaraday
28-12-2023
3
3
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Ebook "Plant stress tolerance: Methods and protocols (Second edition)" provides up-to-date and new chapters covering the most important widely-used techniques in plant stress tolerance, including cutting-edge strategies, in a manner that ensures effective results. Plant Stress Tolerance: Methods and Protocols, Second Edition guides readers through reviews on epigenetics, long noncoding RNAs, and the influence of microbiome on drought tolerance.
354p
lucchinguyen
28-12-2023
6
2
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Vulvar squamous cell carcinoma (VSCC) is an uncommon gynecologic malignancy but with an increasing incidence in recent years. Etiologically, VSCC is classifed into two subtypes: HPV-dependent and HPV-independent. Localized VSCC is treated surgically and/or with radiation therapy, but for advanced, metastatic or recurrent disease, therapeutic options are still limited.
10p
vialfrednobel
23-12-2023
4
4
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Breast cancer is a malignant tumour that seriously threatens women’s life and health and exhibits high inter-individual heterogeneity, emphasising the need for more in-depth research on its pathogenesis. While internal 7-methylguanosine (m7G) modifications affect RNA processing and function and are believed to be involved in human diseases, little is currently known about the role of m7G modification in breast cancer.
21p
visharma
20-10-2023
4
2
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Thyroid cancer (TC) is one of the most common endocrine malignancies, and its morbidity continues to rise. N6 -methyladenosine (m6 A) RNA methylation, an epigenetic modification, is an important regulator of gene expression in TC.
13p
vioracle
29-09-2023
5
3
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Continued part 1, part 2 of ebook "Thermophiles and thermozymes" provides readers with content including: production and characterization of an extracellular acid protease from thermophilic brevibacillus sp. OA30 isolated from an algerian hot spring; transfer RNA modification enzymes from thermophiles and their modified nucleosides in tRNA; thermophilic proteins as versatile scaffolds for protein engineering; cellulases from thermophiles found by metagenomics;...
105p
lytamnguyet
04-08-2023
8
5
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In this paper, we show a detailed look at the barley XTH gene family, including detailed bioinformatics analyses of conserved protein motifs and structure, phylogenetic relationships, and a comparison of the expression patterns during germination and seedling growth using RT-qPCR and RNA-Seq analyses. Overall, there was a good correlation between RT-qPCR and RNA-Seq data for similar tissues. RNA-Seq data showed many different expression profile patterns, from broad, high level expression for some XTH genes to highly tissue specific patterns for others.
17p
lyhuyenthu
31-01-2023
6
2
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Several recent studies have confirmed epigenetic regulation of the immune response. However, the potential role of RNA N6-methyladenosine (m6 A) modifications in cervical cancer and tumour microenvironment (TME) cell infiltration remain unclear.
13p
vihagrid
30-01-2023
6
3
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Over 170 post-transcriptional RNA modifications have been described and are common in all kingdoms of life. These modifications range from methylation to complex chemical structures, with methylation being the most abundant. RNA modifications play a key role in RNA folding and function and their dysregulation in humans has been linked to several diseases such as cancer, metabolic diseases or neurological disorder
10p
viginny
23-12-2022
13
3
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RNA methylation refers to a form of methyl modification in RNA that modulates various epigenetic alterations. Mounting studies have focused on its potential mechanisms in cancer initiation and progression. However, the prognostic value and potential role of RNA methylation in the immune microenvironment of pancreatic cancer remain unclear.
19p
vikolindagrabar
27-07-2022
2
2
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N6-methyladenosine (m6A) modification and long non-coding RNAs (lncRNAs) play pivotal roles in gastric cancer (GC) progression. The emergence of immunotherapy in GC has created a paradigm shift in the approaches of treatment, whereas there is significant heterogeneity with regard to degree of treatment responses, which results from the variability of tumor immune microenvironment (TIME).
19p
vikolindagrabar
27-07-2022
5
3
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N6 -methyladenosine (m6 A) mRNA modification triggers malignant behaviors of tumor cells and thereby drives malignant progression in gastric cancer (GC). However, data regarding the prognostic values of m6 A RNA methylation-related long non-coding RNAs (lncRNAs) in GC are very limited in the literature.
11p
viangelamerkel
27-07-2022
4
1
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Long non-coding RNAs (lncRNAs) play an important role in angiogenesis, immune response, inflammatory response and tumor development and metastasis. m6 A (N6—methyladenosine) is one of the most common RNA modifications in eukaryotes.
18p
visusanwojcicki
28-06-2022
13
3
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