Scientific discovery

"Mobility, data mining & privacy: Geographic knowledge discovery" is aimed at shaping up this frontier of research, from a computer science perspective: we investigate the various scientific and technological achievements that are needed to face the challenge, and discuss the current state of the art, the open problems and the expected road-map of research.

412p zizaybay1103 29-05-2024 3 2   Download

We investigated the effects of just-in-time guidance at various stages of inquiry learning by novice learners. Thirteen participants, randomly assigned to an intervention (n = 8) or control (n = 5) group, were observed as they learned about DC electric circuits using a web-based simulation.

19p viarnault 25-04-2024 3 2   Download

Given the rarity of most single-gene Mendelian disorders, concerted efforts of data exchange between clinical and scientific communities are critical to optimize molecular diagnosis and novel disease gene discovery.

15p vioraclene 31-03-2024 2 2   Download

Ebook "Reducing drug attrition (Topics in Medicinal chemistry, Volume 11)" is to provide guidance to those persons who are dedicated to the creation and development of new drugs to aid patients. Our aim was to address the key factors that have led to failure of preclinical and clinical drug candidates. Despite the significant scientific advances over the past few decades in the disciplines associated with research and development (R&D), the overall productivity, as measured by new approved drugs, has not improved.

176p tudohanhtau1006 29-03-2024 1 1   Download

Ebook "The periodic table" is a collection of short stories that elegantly interlace the author's experiences in Fascist Italy, and later in Auschwitz, with his passion for scientific knowledge and discovery. This Penguin Modern Classics edition of is translated by Raymond Rosenthal with an essay on Primo Levi by Philip Roth.

236p coduathanh1122 27-03-2024 4 1   Download

Francis Bacon is one of the typical representatives of Western European materialism as well as among the most important and influential philosophers who made substantial contributions towards natural philosophy and the field of scientific methodology in the early modern era.

11p vibego 02-02-2024 1 0   Download

This book explores big questions like these, explaining the breakthroughs and discoveries that have shaped our modern-day understanding of medicine and helped us protect and promote our health. Written in plain English, The Medicine Book cuts through the jargon and is packed with pithy explanations of the most important milestones in medical history, with step-by-step diagrams and witty illustrations that untangle knotty concepts. Please refer to Ebook The Medicine Book: Big ideas simply explained - Part 1 for more details.

163p haojiubujain03 09-08-2023 5 3   Download

Part of the popular Big Ideas series, The Science Book explores the history of science, how scientists have sought to explain our incredible universe and how amazing scientific discoveries have been made. Discover how Galileo worked out his scientific theories of motion and inertia, why Copernicus's ideas were contentious and what the discovery of DNA meant.

107p haojiubujain03 09-08-2023 9 4   Download

This book is about a new, fourth paradigm for science based on dataintensive computing. In such scientific research, we are at a stage of development that is analogous to when the printing press was invented. Printing took a thousand years to develop and evolve into the many forms it takes today. Using computers to gain understanding from data created and stored in our electronic data stores will likely take decades—or less.

287p haojiubujain03 24-07-2023 6 4   Download

The most used search engine for scientific literature, PubMed, provides tools to filter results by several fields. When searching for reports on clinical trials, sample size can be among the most important factors to consider.

6p visteverogers 24-06-2023 7 2   Download

The 4th industrial revolution is paved by scientific breakthroughs into the microscopic world and the discovery of new world laws, including 3D printing technology. 3D printing is a "additive manufacturing" technology. This technology works in reverse of “subtraction manufacturing”, gradually removing excess material from the original workpiece in order to finally obtain the desired product.

6p viellenkullman 17-05-2022 13 5   Download

Exploration of large data sets, such as shotgun metagenomic sequence or expression data, by biomedical experts and medical professionals remains as a major bottleneck in the scientific discovery process. Although tools for this purpose exist for 16S ribosomal RNA sequencing analysis, there is a growing but still insufficient number of user-friendly interactive visualization workflows for easy data exploration and figure generation. The development of such platforms for this purpose is necessary to accelerate and streamline microbiome laboratory research.

11p vibeauty 23-10-2021 10 1   Download

The emergence of high throughput technologies that produce vast amounts of genomic data, such as next-generation sequencing (NGS) is transforming biological research. The dramatic increase in the volume of data, the variety and continuous change of data processing tools, algorithms and databases make analysis the main bottleneck for scientific discovery.

16p vijeeni2711 24-07-2021 13 1   Download

Professionals in the biomedical domain are confronted with an increasing mass of data. Developing methods to assist professional end users in the field of Knowledge Discovery to identify, extract, visualize and understand useful information from these huge amounts of data is a huge challenge.

10p viwyoming2711 16-12-2020 9 1   Download

A low replication rate has been reported in some scientific areas motivating the creation of resource intensive collaborations to estimate the replication rate by repeating individual studies.

10p viwyoming2711 16-12-2020 10 1   Download

The well-known Genome-Wide Association Studies (GWAS) had led to many scientific discoveries using SNP data. Even so, they were not able to explain the full heritability of complex diseases. Now, other structural variants like copy number variants or DNA inversions, either germ-line or in mosaicism events, are being studies.

11p vikentucky2711 24-11-2020 10 1   Download

The 2016 International Conference on Intelligent Biology and Medicine (ICIBM 2016) was held on December 8–10, 2016 in Houston, Texas, USA. ICIBM included eight scientific sessions, four tutorials, one poster session, four highlighted talks and four keynotes that covered topics on 3D genomics structural analysis, next generation sequencing (NGS) analysis, computational drug discovery, medical informatics, cancer genomics, and systems biology.

3p viflorida2711 30-10-2020 23 1   Download

The biomedical literature is expanding at ever-increasing rates, and it has become extremely challenging for researchers to keep abreast of new data and discoveries even in their own domains of expertise.

13p vicoachella2711 27-10-2020 13 0   Download

In the era of information overload, natural language processing (NLP) techniques are increasingly needed to support advanced biomedical information management and discovery applications. In this paper, we present an in-depth description of SemRep, an NLP system that extracts semantic relations from PubMed abstracts using linguistic principles and UMLS domain knowledge.

28p vicolorado2711 22-10-2020 9 0   Download

This lecture we focus on Darwin’s ideas on evolution. The students should also learn how his scientific work was the basis for criticism but also new research. Have them research the following questions and share their findings with the class: Was Darwin right? Was he wrong? What new discoveries have helped scientists understand better how species evolve? What’s the current thinking?

10p nanhankhuoctai2 25-05-2020 7 3   Download