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Score profiles
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The benefit of precision medicine based on relatively limited gene sets and often-archived samples remains unproven. PERMED-01 (NCT02342158) was a prospective monocentric clinical trial assessing, in adults with advanced solid cancer, the feasibility and impact of extensive molecular profiling applied to newly biopsied tumor sample and based on targeted NGS (t-NGS) of the largest gene panel to date and whole-genome arraycomparative genomic hybridization (aCGH) with assessment of single-gene alterations and clinically relevant genomic scores.
20p
vibransone
28-03-2024
3
1
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The mutational profile of cancer reflects the activity of the mutagenic processes which have been operative throughout the lineage of the cancer cell. These processes leave characteristic profiles of somatic mutations called mutational signatures. Mutational signatures, including single-base substitution (SBS) signatures, may reflect the effects of exogenous or endogenous exposures.
16p
viellison
28-03-2024
8
2
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Crohn’s disease (CD) patients demonstrate distinct intestinal microbial compositions and metabolic characteristics compared to unafected controls. However, the impact of inflammation and underlying genetic risk on these microbial profiles and their relationship to disease phenotype are unclear. We used lavage sampling to characterize the colonic mucosal-luminal interface (MLI) microbiome of CD patients in endoscopic remission and unafected controls relative to obesity, disease genetics, and phenotype
20p
viellison
28-03-2024
5
2
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Ebook "Applied data mining: Statistical methods for business and industry" includes contents: Chapter 1 introduction, chapter 2 organisation of the data, chapter 3 exploratory data analysis, chapter 4 computational data mining, chapter 5 statistical data mining, chapter 6 evaluation of data mining methods, chapter 7 market basket analysis, chapter 8 web clickstream analysis, chapter 9 profiling website visitors, chapter 10 customer relationship management, chapter 11 credit scoring, chapter 12 forecasting television audience.
378p
haojiubujain08
01-11-2023
7
1
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Part 2 book "Bacterial fish diseases - Environmental and economic vonstraints" includes content: Evaluation of the Fish Invasiveness Scoring Kit for pleco fish or devil fish, profiling of common bacterial pathogens in fish, status of furunculosis in fish fauna, bacterial gill disease and aquatic pollution - a serious concern for the aquaculture industry,.... and other contents.
215p
oursky08
02-11-2023
5
2
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Biochemical recurrence (BCR) after initial treatment, such as radical prostatectomy, is the most frequently adopted prognostic factor for patients who suffer from prostate cancer (PCa). In this study, we aimed to construct a prognostic model consisting of gene expression profiles to predict BCR-free survival.
11p
viangelamerkel
27-07-2022
6
3
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The goal of this study was to compare the influence of an interscalene brachial plexus block (ISB) performed with either bupivacaine or levobupivacaine in conjunction with general anaesthesia (GA) on desflurane consumption, which was titrated to maintain the recovery profiles and postoperative analgesia while also keeping the bispectral index score (BIS) between 40 and 60 in patients undergoing arthroscopic shoulder surgery.
7p
viisaacnewton
25-04-2022
16
1
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Lower levels of tryptophan (TRP) have been identified in people with inflammatory bowel disease and in dogs with protein-losing enteropathy (PLE). No data on serum amino acids (AAs) but some on plasma in canine immunosuppressant-responsive enteropathy (IRE) are available.
9p
vigalileogalilei
28-02-2022
11
1
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Genome-wide DNA methylation (DNAm) profiling has allowed for the development of molecular predictors for a multitude of traits and diseases. Such predictors may be more accurate than the self-reported phenotypes and could have clinical applications.
11p
vigalileogalilei
27-02-2022
10
1
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People with neurodegenerative disorders show diverse clinical syndromes, genetic heterogeneity, and distinct brain pathological changes, but studies report overlap between these features. DNA methylation (DNAm) provides a way to explore this overlap and heterogeneity as it is determined by the combined effects of genetic variation and the environment.
30p
viarchimedes
26-01-2022
7
0
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To investigate the difference between doublet and triplet neoadjuvant chemotherapy (NAC) regimens in efficacy and safety profile. Methods: A total of 227 locally advanced gastric cancer (LAGC) patients who received NAC and sequential radical gastrectomy were reviewed. After propensity score matching (PSM), 140 patients with similar baseline characteristics were selected.
11p
vielonmusk
21-01-2022
7
2
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The total protein content of the pie was 9.70%. This formula contained high percentage of essential amino acids. The percentage of total essential amino acids in the protein was 42.46%, it was rich in cysteine (2.29%), valine (11.48%), isoleucine (5.25%) and phenyl alanine (5.58%) compared to those of casein.
5p
schindler
30-12-2021
7
0
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The MIC value of compound 30 against Enterococcus faecalis, Listeria monocytogenes, and Bacillus cereus was 8 µg/mL. A computational study for prediction of ADME and drug-like properties (solubility, drug-likeness, and drug score) as well as potential toxicity profiles of compounds 2–40 was performed using the Molinspiration online property calculation toolkit and Osiris Property Explorer. As most of our compounds meet Lipinski’s rule of five, they promise good solubility and permeability.
25p
langthannam
29-12-2021
10
1
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The essence of energy metabolism has spread to the field of esophageal cancer (ESC) cells. Herein, we tried to develop a prognostic prediction model for patients with ESC based on the expression profiles of energy metabolism associated genes.
17p
vianrose2711
27-04-2021
14
3
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Prioritizing genetic variants is a challenge because disease susceptibility loci are often located in genes of unknown function or the relationship with the corresponding phenotype is unclear. A global data-mining exercise on the biomedical literature can establish the phenotypic profile of genes with respect to their connection to disease phenotypes.
13p
vikentucky2711
26-11-2020
10
1
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Handling the vast amount of gene expression data generated by genome-wide transcriptional profiling techniques is a challenging task, demanding an informed combination of pre-processing, filtering and analysis methods if meaningful biological conclusions are to be drawn.
10p
vikentucky2711
26-11-2020
13
3
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Compound selectivity is an important issue when developing a new drug. In many instances, a lack of selectivity can translate to increased toxicity. Protein kinases are particularly concerned with this issue because they share high sequence and structural similarity. However, selectivity may be assessed early on using data generated from protein kinase profiling panels.
12p
vioklahoma2711
19-11-2020
9
1
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The statistical evaluation of pathway enrichment, i.e. of gene profiles' confluence to the pathway level, allows exploring molecular landscapes using functionally annotated gene sets. However, pathway scores can also be used as predictive features in machine learning.
10p
vioklahoma2711
19-11-2020
10
1
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The Top Scoring Pair (TSP) classifier, based on the concept of relative ranking reversals in the expressions of pairs of genes, has been proposed as a simple, accurate, and easily interpretable decision rule for classification and class prediction of gene expression profiles.
13p
viconnecticut2711
28-10-2020
20
1
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The aim of the study is to evaluate APACHE II score in Acinetobacter baumannii infected or colonized patients and antimicrobial resistant pattern of isolates.
6p
chauchaungayxua8
03-10-2020
13
2
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