Secretory protein

The IRE1a-XBP1 pathway is a conserved adaptive mediator of the unfolded protein response. The pathway is indispensable for the development of secretory cells by facilitating protein folding and enhancing secretory capacity.

19p vibransone 28-03-2024 5 2   Download

Part 2 book "Handbook of venoms and toxins of reptiles" includes content: Snake venom three finger toxins; sarafotoxins, the snake venom homologs of the endothelins; cysteine rich secretory proteins in reptile venoms; snake venomics and disintegrins - portrait and evolution of a family of snake venom integrin antagonists;... and other contents.

273p muasambanhan06 03-02-2024 2 1   Download

Part 1 book "Venomous reptiles and their toxins, evolution, pathophysiology and biodiscovery" includes content: The origin and evolution of the toxicofera reptile venom system; signs, symptoms, and treatment of envenomation; antivenom research and development; ineffective traditional and modern techniques for the treatment of snakebite; maintaining venomous reptile collections - protocols and occupational safety; veterinary care of venomous reptiles; research methods; three finger toxins; beta defensins; cysteine rich secretory proteins; exendin peptides.

312p oursky09 08-11-2023 7 3   Download

Tumor cell-monocyte interactions play crucial roles in shaping up the pro-tumorigenic phenotype and functional output of tumor-associated macrophages. Within the tumor microenvironment, such heterotypic cell–cell interactions are known to occur via secretory proteins.

18p visharma 20-10-2023 4 2   Download

Bài viết Ứng dụng kháng nguyên TES-30 tái tổ hợp xác định kháng thể IgG trong huyết thanh bệnh nhân nhiễm Toxocara bằng kỹ thuật ELISA trình bày việc sử dụng kháng nguyên TES (Toxocara Excretory-Secretory) tái tổ hợp làm nguyên liệu tạo bộ sinh phẩm ELISA phát hiện kháng thể IgG kháng ấu trùng giun đũa chó/mèo để khắc phục nhược điểm về độ nhạy và độ đặc hiệu thấp khi sử dụng kháng nguyên thô TES.

9p vipierre 29-09-2023 6 2   Download

Part 2 book "Cell biology" includes content: Posttranslational targeting of proteins; mitochondria, chloroplasts, peroxisomes; endoplasmic reticulum; secretory membrane system and golgi apparatus; endocytosis and the endosomal membrane system; processing and degradation of cellular components; plasma membrane receptors; protein hardware for signaling... and other contents.

584p oursky04 14-09-2023 4 3   Download

McCune–Albright syndrome is a complex disorder encompassing multiple endocrinopathies. These manifestations are secondary to a mutation in the stimulatory G-protein alpha subunit. Cushing syndrome is due to autonomous secretory function of the adrenal gland and is present in 7.1% of patients with McCune–Albright syndrome.

5p vigamora 23-05-2023 7 2   Download

Canine colostrum milk (CCM) is a specific secretion of the mammary gland that is fundamental for the survival of the newborn. CCM has many described components (immunoglobulins, proteins or fat), but its small vesicles, named exosomes, are largely unknown.

11p vigandhi 23-02-2022 18 1   Download

Mastitis is the most common disease in dairy cattle and the costliest for the dairy farming industry, as it lowers milk yield and quality. Mastitis occurs as a result of interactions between microorganisms and the individual genetic predispositions of each animal.

9p vigandhi 23-02-2022 9 1   Download

Cancer stem cells (CSCs) are implicated in carcinogenesis, cancer progression, and recurrence. Several biomarkers have been described for pancreatic ductal adenocarcinoma (PDAC) CSCs; however, their function and mechanism remain unclear.

19p vimahuateng 26-11-2021 8 1   Download

Tumor microenvironment (TME) critically contributed to the malignant progression of transformed cells and the chemical responses to chemotherapy reagents. Osteopontin (OPN) is a secretory onco-protein with several splicing isoforms, all of which were known to regulate tumor growth and able to alter cell-cell or cell-TME communication, however, the exact role and regulation of the OPN splicing isoforms was not well understood.

14p vimahuateng 26-11-2021 3 0   Download

Our results indicate that, in addition to previously reported L1 elements, various LTR and DNA transposons, as well as members of the classical satellites including HSAT5 and α-satellites (ALR/Alpha), are expressed at higher levels in late senescence. Moreover, we revealed finer links between the expression levels of repeats with the genes located near them and known to be involved in cell cycle and senescence. Noncoding elements reported here provide a new perspective to be explored in further experimental studies.

15p thiencuuchu 27-11-2021 12 2   Download

In the present study, attempts were made to produce biologically active recombinant mouse hephaestin as a secretory form tagged with green fluorescent protein (GFP), Hpsec-GFP. Plasmid expressing Hpsec-GFP was constructed and transfected into COS and CHO cells. The GFP aided the monitoring expression in real time to select the best conditions to maximise expression and provided a tag for purifying and analysing Hpsec-GFP. The protein had detectable oxidase activity as shown by in-gel and solution-based assays.

13p thiencuuchu 27-11-2021 8 1   Download

Protein secretion is an essential process in all eukaryotes including organisms belonging to the phylum Apicomplexa, which includes many intracellular parasites. The apicomplexan parasites possess a specialized collection of secretory organelles that release a number of proteins to facilitate the invasion of host cells and some of these proteins also participate in immune evasion.

13p vigiselle2711 30-08-2021 7 1   Download

All eukaryotes share a conserved network of processes regulated by the proteasome and fundamental to growth, development, or perception of the environment, leading to complex but often predictable responses to stress.

12p viansan2711 30-07-2021 13 1   Download

Secretory leukocyte protease inhibitor (SLPI) is a protein with anti-protease and antimicrobial properties that is constitutively secreted from the airway epithelium. The importance of maintaining a balance between proteases and anti-proteases, and robust innate defence mechanisms in the airways, is exemplified by inflammatory lung conditions such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF).

7p vimontana2711 05-04-2021 12 1   Download

Secretoglobin (SCGB) 3A2, a cytokine-like secretory protein of small molecular weight, is predominantly expressed in airway epithelial cells. While SCGB3A2 is known to have anti-inflammatory, growth factor, and anti-fibrotic activities, whether SCGB3A2 has any other roles, particularly in lung homeostasis and disease has not been demonstrated in vivo. The aim of this study was to address these questions in mice.

13p vimontana2711 05-04-2021 8 2   Download

The objectives of this study were to (1) to quantify CD45+ Collagen-1+ fibrocytes and a novel epithelial-like population of bone marrow-derived cells, which express Clara Cell Secretory Protein, in patients at the time of lung transplant and (2) to evaluate mediators that may act to recruit these cells during injury.

12p vimontana2711 05-04-2021 11 1   Download

Fibroblast growth factor-2 (FGF-2) is a multifunctional protein that plays an important role in the regulation of proliferation, differentiation and migration of a variety of cells. The recombinant human FGF-2 (rhFGF-2) is currently used in stem cell culture, medicine and cosmetic products. In this study, we aim to produce secreted rhFGF-2 protein from a Pichia pastoris strain containing multiple copies of the fgf-2 gene to eliminate the disadvantages of intracellular expression systems

9p larachdumlanat127 02-01-2021 12 2   Download

Many plant pathogen secretory proteins are known to be elicitors or pathogenic factors,which play an important role in the host-pathogen interaction process. Bioinformatics approaches make possible the large scale prediction and analysis of secretory proteins from the Puccinia helianthi transcriptome.

13p vioklahoma2711 19-11-2020 7 1   Download